Gunnar Kallies, Michael A. Rapp, Thomas Fydrich, Lydia Fehm, Mira Tschorn, Christina Teran, Melanie Schwefel, Anou F. Pietrek, Romy Henze, Rainer Hellweg, Andreas Ströhle, Stephan Heinzel, Andreas Heissel
- Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus,Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.…
MetadatenAuthor details: | Gunnar Kallies, Michael A. RappORCiDGND, Thomas FydrichORCiDGND, Lydia FehmORCiD, Mira TschornORCiDGND, Christina Teran, Melanie Schwefel, Anou F. PietrekORCiDGND, Romy Henze, Rainer Hellweg, Andreas StröhleORCiDGND, Stephan HeinzelORCiDGND, Andreas HeisselORCiDGND |
---|
DOI: | https://doi.org/10.1016/j.psyneuen.2018.12.015 |
---|
ISSN: | 0306-4530 |
---|
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30583245 |
---|
Title of parent work (English): | Psychoneuroendocrinology |
---|
Publisher: | Elsevier |
---|
Place of publishing: | Oxford |
---|
Publication type: | Article |
---|
Language: | English |
---|
Date of first publication: | 2018/12/14 |
---|
Publication year: | 2018 |
---|
Release date: | 2021/03/10 |
---|
Tag: | Brain-derived neurotrophic factor (BDNF); Major depressive disorder; Physical exercise; Platelets |
---|
Volume: | 102 |
---|
Number of pages: | 4 |
---|
First page: | 212 |
---|
Last Page: | 215 |
---|
Funding institution: | German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [HE7464/2-1, FY1/5-1, STR504/6-1]; Dalla Vecchia Foundation on Depression Research (Dalla Vecchia Stiftung Depressionsforschung); University of Potsdam; Potsdam Graduate School, University of Potsdam |
---|
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
---|
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Peer review: | Referiert |
---|