P. Vitali, Jubin Abutalebi, M. Tettamanti, J. Rowe, P. Scifo, F. Fazio, Stefano F. Cappa, Daniela Perani

• The present fMRI study of semantic fluency for animal and tool names provides further evidence for category- specific brain activations, and reports task-related changes in effective connectivity among defined cerebral regions. Two partially segregated systems of functional integration were highlighted: the tool condition was associated with an enhancement of connectivity within left hemispheric regions, including the inferior prefrontal and premotor cortex, the inferior parietal lobule and the temporo-occipital junction; the animal condition was associated with greater coupling among left visual associative regions. These category-specific functional differences extend the evidence for anatomical specialization to lexical search tasks, and provide for the first time evidence of category-specific patterns of functional integration in word-retrieval. (c) 2004 Elsevier Inc. All rights reserved