Developmental Origins of Disease - Crisis Precipitates Change
- The concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines generalThe concept of developmental origins of diseases has gained a huge interest in recent years and is a constantly emerging scientific field. First observations hereof originated from epidemiological studies, linking impaired birth outcomes to adult chronic, noncommunicable disease. By now there is a considerable amount of both epidemiological and experimental evidence highlighting the impact of early life events on later life disease susceptibility. Albeit far from being completely understood, more recent studies managed to elucidate underlying mechanisms, with epigenetics having become almost synonymous with developmental programming. The aim of this review was to give a comprehensive overview of various aspects and mechanisms of developmental origins of diseases. Starting from initial research foci mainly centered on a nutritionally impaired intrauterine environment, more recent findings such as postnatal nutrition, preterm birth, paternal programming and putative interventional approaches are summarized. The review outlines general underlying mechanisms and particularly discusses mechanistic explanations for sexual dimorphism in developmental programming. Furthermore, novel hypotheses are presented emphasizing a non-mendelian impact of parental genes on the offspring's phenotype.…
Author details: | Christoph ReichetzederORCiDGND, Sulistyo Emantoko Dwi Putra, Jian Li, Berthold HocherORCiDGND |
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DOI: | https://doi.org/10.1159/000447801 |
ISSN: | 1015-8987 |
ISSN: | 1421-9778 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/27513464 |
Title of parent work (English): | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry and pharmacology |
Publisher: | Karger |
Place of publishing: | Basel |
Publication type: | Review |
Language: | English |
Year of first publication: | 2016 |
Publication year: | 2016 |
Release date: | 2020/03/22 |
Tag: | Developmental programming; Epigenetics; Nutrition; Paternal, maternal, sex differences; Thrifty phenotype |
Volume: | 39 |
Number of pages: | 20 |
First page: | 919 |
Last Page: | 938 |
Funding institution: | Deutsche Forschungsgemeinschaft (DFG); European Commission; National Natural Science Foundation of China [81300557]; Hunan Province Science and Technology Plan [2014SK3003]; Program for Excellent Talents of Hunan Normal University [ET14106] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
Peer review: | Referiert |