Surface functionalization of poly(ether imide) membranes with linear, methylated oligoglycerols for reducing thrombogenicity
- Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
| Verfasserangaben: | Maik Lange, Steffen BrauneGND, Karola Luetzow, Klaus Richau, Nico Scharnagl, Marie Weinhart, Axel T. NeffeORCiDGND, Friedrich JungORCiD, Rainer HaagORCiDGND, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1002/marc.201200426 |
| ISSN: | 1022-1336 |
| Titel des übergeordneten Werks (Englisch): | Macromolecular rapid communications |
| Verlag: | Wiley-VCH |
| Verlagsort: | Weinheim |
| Publikationstyp: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Jahr der Erstveröffentlichung: | 2012 |
| Erscheinungsjahr: | 2012 |
| Datum der Freischaltung: | 26.03.2017 |
| Freies Schlagwort / Tag: | hemocompatibility; poly(ethylene glycol); polyglycerol; polyimides; surface chemistry |
| Band: | 33 |
| Ausgabe: | 17 |
| Seitenanzahl: | 6 |
| Erste Seite: | 1487 |
| Letzte Seite: | 1492 |
| Fördernde Institution: | Bundesministerium fur Bildung und Forschung (BMBF) through wPoly4Bio BB; Helmholtz Association through the Helmholtz Virtual Institute |
| Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer Review: | Referiert |
