- Objective: To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood.
Design: Longitudinal, prospective study of a German community sample.
Subjects: n = 306 young adults (139 males, 167 females).
Measurements: Participants' body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped.
Results: Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development.
Conclusions: This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due toObjective: To investigate the association of the neuropeptide Y (NPY) promoter polymorphism rs16147 with body mass index (BMI) during the course of development from infancy to adulthood.
Design: Longitudinal, prospective study of a German community sample.
Subjects: n = 306 young adults (139 males, 167 females).
Measurements: Participants' body weight and height were assessed at the ages of 3 months and 2, 4.5, 8, 11, 15 and 19 years. NPY rs16147 was genotyped.
Results: Controlling for a number of possible confounders, homozygote carriers of the rs16147 C allele exhibited significantly lower BMI scores when compared with individuals carrying the T allele. In addition, a significant genotype by age interaction emerged, indicating that the genotype effect increased during the course of development.
Conclusions: This is the first longitudinal study to report an association between rs16147 and BMI during childhood and adolescence. The finding that this effect increased during the course of development may either be due to age-dependent alterations in gene expression or to maturation processes within the weight regulation circuits of the central nervous system.…
MetadatenVerfasserangaben: | S. Hohmann, Arlette F. Buchmann, S. H. Witt, M. Rietschel, Christine Jennen-Steinmetz, M. H. Schmidt, Günter EsserORCiDGND, Tobias BanaschewskiORCiD, Manfred LauchtGND |
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DOI: | https://doi.org/10.1111/j.2047-6310.2012.00069.x |
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ISSN: | 2047-6310 |
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Titel des übergeordneten Werks (Englisch): | Pediatric obesity |
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Verlag: | Wiley-Blackwell |
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Verlagsort: | Hoboken |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Jahr der Erstveröffentlichung: | 2012 |
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Erscheinungsjahr: | 2012 |
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Datum der Freischaltung: | 26.03.2017 |
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Freies Schlagwort / Tag: | Development; neuropeptide Y; rs16147; weight regulation |
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Band: | 7 |
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Ausgabe: | 6 |
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Seitenanzahl: | 8 |
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Erste Seite: | 453 |
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Letzte Seite: | 460 |
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Fördernde Institution: | Lilly; Janssen McNeil; Medice; Novartis; Shire; UCB; German Research
Foundation (DFG); Federal Ministry for Education and Research,
'Baden-Wuerttemberg Consortium for Addiction Research'; Federal Ministry
for Education and Research, 'National Genome Research Network' |
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Organisationseinheiten: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Psychologie |
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Peer Review: | Referiert |
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Name der Einrichtung zum Zeitpunkt der Publikation: | Humanwissenschaftliche Fakultät / Institut für Psychologie |
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