Multicompartment micelles from silicone-based triphilic block copolymers
- An amphiphilic linear ternary block copolymer was synthesised in three consecutive steps via reversible addition-fragmentation chain transfer polymerisation. Oligo(ethylene glycol) monomethyl ether acrylate was engaged as a hydrophilic building block, while benzyl acrylate and 3-tris(trimethylsiloxy)silyl propyl acrylate served as hydrophobic building blocks. The resulting "triphilic" copolymer consists thus of a hydrophilic (A) and two mutually incompatible "soft" hydrophobic blocks, namely, a lipophilic (B) and a silicone-based (C) block, with all blocks having glass transition temperatures well below 0 A degrees C. The triphilic copolymer self-assembles into spherical multicompartment micellar aggregates in aqueous solution, where the two hydrophobic blocks undergo local phase separation into various ultrastructures as evidenced by cryogenic transmission electron microscopy. Thus, a silicone-based polymer block can replace the hitherto typically employed fluorocarbon-based hydrophobic blocks in triphilic block copolymers forAn amphiphilic linear ternary block copolymer was synthesised in three consecutive steps via reversible addition-fragmentation chain transfer polymerisation. Oligo(ethylene glycol) monomethyl ether acrylate was engaged as a hydrophilic building block, while benzyl acrylate and 3-tris(trimethylsiloxy)silyl propyl acrylate served as hydrophobic building blocks. The resulting "triphilic" copolymer consists thus of a hydrophilic (A) and two mutually incompatible "soft" hydrophobic blocks, namely, a lipophilic (B) and a silicone-based (C) block, with all blocks having glass transition temperatures well below 0 A degrees C. The triphilic copolymer self-assembles into spherical multicompartment micellar aggregates in aqueous solution, where the two hydrophobic blocks undergo local phase separation into various ultrastructures as evidenced by cryogenic transmission electron microscopy. Thus, a silicone-based polymer block can replace the hitherto typically employed fluorocarbon-based hydrophobic blocks in triphilic block copolymers for inducing multicompartmentalisation.…
Author details: | Jean-Noel Marsat, Frank Stahlhut, André LaschewskyORCiDGND, Hans von Berlepsch, Christoph Böttcher |
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DOI: | https://doi.org/10.1007/s00396-013-3001-2 |
ISSN: | 0303-402X |
ISSN: | 1435-1536 |
Title of parent work (English): | Colloid and polymer science : official journal of the Kolloid-Gesellschaft |
Publisher: | Springer |
Place of publishing: | New York |
Publication type: | Article |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Tag: | Amphiphiles; Core-shell-corona micelles; Cryo-TEM; Multicompartment micelles; RAFT; Triphilic block copolymers |
Volume: | 291 |
Issue: | 11 |
Number of pages: | 7 |
First page: | 2561 |
Last Page: | 2567 |
Funding institution: | Deutsche Forschungsgemeinschaft [LA611/5, BO1000/8] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |