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4 '-Prenyloxyderrone from the stem bark of Millettia oblata ssp teitensis and the antiplasmodial activities of isoflavones from some Millettia species

  • The CH2Cl2/MeOH (1: 1) extract of the stem bark of Millettia oblata ssp. teitensis showed antiplasmodial activity (IC50 = 10-12 mu g/mL) against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the isolation of a new isoflavone, 4'-prenyloxyderrone (1), together with known isoflavones (8-O-methylretusin, durmillone, maximaisoflavone B, maximaisoflavone H and maximaisoflavone J), a rotenoid (tephrosin) and a triterpene (lupeol). Similar investigation of Millettia leucantha resulted in the identification of the isoflavones afrormosin and wistin, and the flavone chrysin. The identification of these compounds was based on their spectroscopic data. Five of the isoflavones isolated from these plants as well as 11 previously reported compounds from Millettia dura were tested and showed good to moderate antiplasmodial activities (IC50 = 13-53 mu M), with the new compound, 4'-prenyloxyderrone, being the most active (IC50 = 13-15 mu M).

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Author:Solomon DereseORCiD, Leonard Barasa, Hoseah M. Akala, Amir O. Yusuf, Edwin Kamau, Matthias Heydenreich, Abiy Yenesew
ISSN:1874-3900 (print)
ISSN:1876-7486 (online)
Parent Title (English):Phytochemistry letters
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2014
Year of Completion:2014
Release Date:2017/03/27
Tag:Millettia dura;; Millettia leucantha; Millettia oblata ssp teitensis
First Page:69
Last Page:72
Funder:IFS; OPCW [F/4581]; International Science Program (ISP, Sweden) [KEN-02]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert