Mira Tschorn, Stella Linnea Kuhlmann, Nina Rieckmann, Katja Beer, Laura Grosse, Volker Arolt, Johannes Waltenberger, Wilhelm Haverkamp, Jacqueline Müller-Nordhorn, Rainer Hellweg, Andreas Ströhle
- Objective:
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF).
Methods:
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment.
Results:
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNFObjective:
Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analysed the relationship between BDNF and depression in a sample of patients with CHD and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS) or congestive heart failure (CHF).
Methods:
The following variables were assessed for 225 hospitalised patients with CHD: BDNF concentrations, depression [Patient Health Questionnaire-9 (PHQ-9)], somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status and antidepressant treatment.
Results:
Regression models revealed that BDNF was not associated with severity of depression. Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p = 0.04), this was not statistically significant after controlling for confounders (p = 0.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p = 0.08, p = 0.06, respectively). BDNF was reduced in patients with CHF (p = 0.02). There was no covariate-adjusted, significant association between BDNF and ACS.
Conclusion:
Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.…
MetadatenAuthor details: | Mira TschornORCiDGND, Stella Linnea KuhlmannORCiDGND, Nina RieckmannORCiDGND, Katja BeerGND, Laura GrosseGND, Volker AroltGND, Johannes WaltenbergerORCiDGND, Wilhelm HaverkampORCiDGND, Jacqueline Müller-NordhornORCiDGND, Rainer HellwegORCiDGND, Andreas StröhleORCiDGND |
---|
URN: | urn:nbn:de:kobv:517-opus4-557315 |
---|
DOI: | https://doi.org/10.25932/publishup-55731 |
---|
ISSN: | 1866-8364 |
---|
Title of parent work (German): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe |
---|
Publication series (Volume number): | Zweitveröffentlichungen der Universität Potsdam : Humanwissenschaftliche Reihe (850) |
---|
Publication type: | Postprint |
---|
Language: | English |
---|
Date of first publication: | 2020/09/24 |
---|
Publication year: | 2020 |
---|
Publishing institution: | Universität Potsdam |
---|
Release date: | 2024/04/24 |
---|
Tag: | BDNF; acute coronary syndrome; coronary heart disease; depression; heart failure; somatic comorbidity |
---|
Issue: | 1 |
---|
Number of pages: | 11 |
---|
Source: | Acta Neuropsychiatrica, 33(1), 22-30. doi:10.1017/neu.2020.31 |
---|
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
---|
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Peer review: | Referiert |
---|
Publishing method: | Open Access / Green Open-Access |
---|
License (German): | CC-BY - Namensnennung 4.0 International |
---|
External remark: | Bibliographieeintrag der Originalveröffentlichung/Quelle |
---|