Osmosensing, osmosignalling and inflammation
- Intervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factorIntervertebral disc (IVD) cells are naturally exposed to high osmolarity and complex mechanical loading, which drive microenvironmental osmotic changes. Age- and degeneration-induced degradation of the IVD’s extracellular matrix causes osmotic imbalance, which, together with an altered function of cellular receptors and signalling pathways, instigates local osmotic stress. Cellular responses to osmotic stress include osmoadaptation and activation of pro-inflammatory pathways. This review summarises the current knowledge on how IVD cells sense local osmotic changes and translate these signals into physiological or pathophysiological responses, with a focus on inflammation. Furthermore, it discusses the expression and function of putative membrane osmosensors (e.g. solute carrier transporters, transient receptor potential channels, aquaporins and acid-sensing ion channels) and osmosignalling mediators [e.g. tonicity response-element-binding protein/nuclear factor of activated T-cells 5 (TonEBP/NFAT5), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)] in healthy and degenerated IVDs. Finally, an overview of the potential therapeutic targets for modifying osmosensing and osmosignalling in degenerated IVDs is provided.…
Author details: | Aleksandra SadowskaORCiD, Takuya KamedaORCiD, Olga KrupkovaORCiDGND, Karin Wuertz-KozakORCiDGND |
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DOI: | https://doi.org/10.22203/eCM.v036a17 |
ISSN: | 1473-2262 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30452080 |
Title of parent work (English): | European cells & materials |
Subtitle (English): | how intervertebral disc cells respond to altered osmolarity |
Publisher: | Ao research institute davos-Ari |
Place of publishing: | Davos |
Publication type: | Article |
Language: | English |
Date of first publication: | 2018/11/19 |
Publication year: | 2018 |
Release date: | 2021/11/08 |
Tag: | Intervertebral disc degeneration; aquaporin; degenerative disc disease; hyper-osmolarity; hypo-osmolarity; inflammatory; osmolarity; osmotic; tonicity-responsive enhancer binding protein; transient receptor potential channel |
Volume: | 36 |
Number of pages: | 20 |
First page: | 231 |
Last Page: | 250 |
Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Peer review: | Referiert |
Publishing method: | Open Access / Green Open-Access |
DOAJ gelistet |