Gunnar Kallies, Michael Armin Rapp, Thomas Fydrich, Lydia Fehm, Mira Tschorn, Christina Teran, Melanie Schwefel, Anou F. Pietrek, Romy Henze, Rainer Hellweg, Andreas Ströhle, Stephan Heinzel, Andreas Heissel
- Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus,Physiological mechanisms of an anti-depressive effect of physical exercise in major depressive disorder (MDD) seem to involve alterations in brain-derived neurotrophic factor (BDNF) level. However, previous studies which investigated this effect in a single bout of exercise, did not control for confounding peripheral factors that contribute to BDNF-alterations. Therefore, the underlying cause of exercise-induced BDNF-changes remains unclear. The current study aims to investigate serum BDNF (sBDNF)-changes due to a single-bout of graded aerobic exercise in a group of 30 outpatients with MDD, suggesting a more precise analysis method by taking plasma volume shift and number of platelets into account. Results show that exercise-induced increases in sBDNF remain significant (p<.001) when adjusting for plasma volume shift and controlling for number of platelets. The interaction of sBDNF change and number of platelets was also significant (p=.001) indicating larger sBDNF-increase in participants with smaller number of platelets. Thus, findings of this study suggest an involvement of peripheral as well as additional possibly brain-derived mechanisms explaining exercise-related BDNF release in MDD. For future studies in the field of exercise-related BDNF research, the importance of controlling for peripheral parameters is emphasized.…
MetadatenVerfasserangaben: | Gunnar Kallies, Michael Armin RappORCiDGND, Thomas Fydrich, Lydia FehmORCiD, Mira TschornORCiD, Christina Teran, Melanie Schwefel, Anou F. PietrekORCiDGND, Romy Henze, Rainer Hellweg, Andreas StröhleORCiDGND, Stephan HeinzelORCiDGND, Andreas HeisselORCiDGND |
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DOI: | https://doi.org/10.1016/j.psyneuen.2018.12.015 |
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ISSN: | 0306-4530 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30583245 |
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Titel des übergeordneten Werks (Englisch): | Psychoneuroendocrinology |
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Verlag: | Elsevier |
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Verlagsort: | Oxford |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Erstveröffentlichung: | 14.12.2018 |
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Erscheinungsjahr: | 2018 |
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Datum der Freischaltung: | 10.03.2021 |
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Freies Schlagwort / Tag: | Brain-derived neurotrophic factor (BDNF); Major depressive disorder; Physical exercise; Platelets |
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Band: | 102 |
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Seitenanzahl: | 4 |
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Erste Seite: | 212 |
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Letzte Seite: | 215 |
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Fördernde Institution: | German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)German Research Foundation (DFG) [HE7464/2-1, FY1/5-1, STR504/6-1]; Dalla Vecchia Foundation on Depression Research (Dalla Vecchia Stiftung Depressionsforschung); University of Potsdam; Potsdam Graduate School, University of Potsdam |
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Organisationseinheiten: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Sport- und Gesundheitswissenschaften |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Peer Review: | Referiert |
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