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Knipholone cyclooxanthrone and an anthraquinone dimer with antiplasmodial activities from the roots of Kniphofia foliosa

  • A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively.

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Author:Negera Abdissa, Martha Induli, Hoseah M. Akala, Matthias Heydenreich, Jacob O. Midiwo, Albert Ndakala, Abiy Yenesew
ISSN:1874-3900 (print)
Parent Title (English):Phytochemistry letters
Place of publication:Amsterdam
Document Type:Article
Year of first Publication:2013
Year of Completion:2013
Release Date:2017/03/26
Tag:10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol; Anthraquinone; Asphodelaceae; Dianellin; Kniphofia foliosa; Knipholone cyclooxanthrone; Malaria; Roots
First Page:241
Last Page:245
Funder:German Academic Exchange Service (DAAD) through Natural Product Research Network of Eastern and Central Africa (NAPRECA); International Science Program (ISP, Sweden) [KEN-02]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert