Modulation of mesenchymal stem cell migration using programmable polymer sheet actuators
- Recruitment of mesenchymal stem cells (MSCs) to damaged tissue is a crucial step to modulate tissue regeneration. Here, the migration of human adipose-derived stem cells (hADSCs) responding to thermal and mechanical stimuli was investigated using programmable shape-memory polymer actuator (SMPA) sheets. Changing the temperature repetitively between 10 and 37 degrees C, the SMPA sheets are capable of reversibly changing between two different pre-defined shapes like an artificial muscle. Compared to non-actuating sheets, the cells cultured on the programmed actuating sheets presented a higher migration velocity (0.32 +/- 0.1 vs. 0.57 +/- 0.2 mu m/min). These results could motivate the next scientific steps, for example, to investigate the MSCs pre-loaded in organoids towards their migration potential.
| Author details: | Zijun DengGND, Weiwei WangGND, Xun Xu, Nan Ma, Andreas LendleinORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1557/adv.2020.235 |
| ISSN: | 2059-8521 |
| Title of parent work (English): | MRS advances |
| Publisher: | Cambridge Univ. Press |
| Place of publishing: | New York |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2020/12/26 |
| Publication year: | 2020 |
| Release date: | 2023/10/02 |
| Volume: | 5 |
| Issue: | 46-47 |
| Article number: | PII S2059852120002352 |
| Number of pages: | 10 |
| First page: | 2381 |
| Last Page: | 2390 |
| Funding institution: | Helmholtz Association of German Research Centers (through program; -oriented finding, Helmholtz Cross Program Initiative "'technology and; Medicine -Adaptive Systems", Helmholtz Virtual Institute,; Multifunctional Biomaterials for Medicine) [VH-VI-423]; Federal Ministry; of Education and Research, Germany, through the Program Health Research; [13GW0098, 0315696A] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
