Knipholone cyclooxanthrone and an anthraquinone dimer with antiplasmodial activities from the roots of Kniphofia foliosa
- A new phenylanthrone, named knipholone cyclooxanthrone and a dimeric anthraquinone, 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol were isolated from the roots of Kniphofia foliosa together with the rare naphthalene glycoside, dianellin. The structures were determined by NMR and mass spectroscopic techniques. The compounds showed antiplasmodial activities against the chloroquine-resistant (W2) and chloroquine-sensitive (D6) strains of Plasmodium falciparum with 10-methoxy-10,7'-(chrysophanol anthrone)-chrysophanol being the most active with IC50 values of 1.17 +/- 0.12 and 4.07 +/- 1.54 mu g/ml, respectively.
Author details: | Negera Abdissa, Martha Induli, Hoseah M. AkalaORCiD, Matthias HeydenreichORCiD, Jacob O. Midiwo, Albert NdakalaORCiD, Abiy YenesewORCiD |
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DOI: | https://doi.org/10.1016/j.phytol.2013.02.005 |
ISSN: | 1874-3900 |
Title of parent work (English): | Phytochemistry letters |
Publisher: | Elsevier |
Place of publishing: | Amsterdam |
Publication type: | Article |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Tag: | 10-Methoxy-10,7 '-(chrysophanol anthrone)-chrysophanol; Anthraquinone; Asphodelaceae; Dianellin; Kniphofia foliosa; Knipholone cyclooxanthrone; Malaria; Roots |
Volume: | 6 |
Issue: | 2 |
Number of pages: | 5 |
First page: | 241 |
Last Page: | 245 |
Funding institution: | German Academic Exchange Service (DAAD) through Natural Product Research Network of Eastern and Central Africa (NAPRECA); International Science Program (ISP, Sweden) [KEN-02] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |