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Sex-specific differences in the association of vitamin D with low lean mass and frailty
- Background: Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype. Methods: A total of 1102 participants (51% women) from the Berlin Aging Study II were included in this cross-sectional study. Vitamin D insufficiency was defined as a 25(OH)D level <50 nmol/L. Lean mass was assessed with dual-energy x-ray absorptiometry and corrected by body mass index. Low lean mass was defined according to the Foundations for the National Institutes of Health Sarcopenia Project criteria (appendicular lean mass/body mass index <0.789 in men and <0.512 in women) and frailty defined according to the Fried criteria. Results: In a risk factor adjusted analysis, the association of vitamin D insufficiency was significantly influenced by sex (P for interaction < 0.001). Men withBackground: Sex-specific differences in factors associated with aging and lifespan, such as sarcopenia and disease development, are increasingly recognized. The study aims to assess sex-specific aspects of the association between vitamin D insufficiency and low lean mass as well as between vitamin D insufficiency and the frailty phenotype. Methods: A total of 1102 participants (51% women) from the Berlin Aging Study II were included in this cross-sectional study. Vitamin D insufficiency was defined as a 25(OH)D level <50 nmol/L. Lean mass was assessed with dual-energy x-ray absorptiometry and corrected by body mass index. Low lean mass was defined according to the Foundations for the National Institutes of Health Sarcopenia Project criteria (appendicular lean mass/body mass index <0.789 in men and <0.512 in women) and frailty defined according to the Fried criteria. Results: In a risk factor adjusted analysis, the association of vitamin D insufficiency was significantly influenced by sex (P for interaction < 0.001). Men with vitamin D insufficiency had 1.8 times higher odds of having low lean mass, with no association between vitamin D insufficiency and low lean mass in women. Participants with vitamin D insufficiency had 1.5 higher odds of being prefrail/frail with no significant effect modification by sex. Conclusions: We found notable sex-specific differences in the association of vitamin D insufficiency with low lean mass but not of vitamin D insufficiency with frailty. Vitamin D might play a relevant role in the loss of lean mass in men but not women and might be a biological marker of an unfavorable aging process associated with early development of frailty regardless of sex.…
Verfasserangaben: | Dominik Spira, Nikolaus Buchmann, Maximilian Koenig, Adrian Rosada, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Kristina NormanORCiDGND |
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DOI: | https://doi.org/10.1016/j.nut.2018.11.020 |
ISSN: | 0899-9007 |
ISSN: | 1873-1244 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30822744 |
Titel des übergeordneten Werks (Englisch): | Nutrition |
Untertitel (Englisch): | results from the Berlin Aging Study II |
Verlag: | Elsevier |
Verlagsort: | New York |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Jahr der Erstveröffentlichung: | 2019 |
Erscheinungsjahr: | 2019 |
Datum der Freischaltung: | 03.02.2021 |
Freies Schlagwort / Tag: | Frailty criteria; Low lean mass; Vitamin D insufficiency |
Band: | 62 |
Seitenanzahl: | 6 |
Erste Seite: | 1 |
Letzte Seite: | 6 |
Fördernde Institution: | German Federal Ministry of Education and Research (BMBF)Federal Ministry of Education & Research (BMBF) [16SV5536K, 01GL1716A]; Charite-Universitatsmedizin Berlin Germany |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Peer Review: | Referiert |