Metal-Free Regioselective Monocyanation of Hydroxy-, Alkoxy-, and Benzyloxyarenes by Potassium Thiocyanate and Silica Sulfuric Acid as a Cyanating Agent
- A novel and efficient metal- and solvent-free regioselective para-C-H cyanation of hydroxy-, alkoxy-, and benzyloxyarene derivatives has been introduced, using nontoxic potassium thiocyanate as a cyanating reagent in the presence of silica sulfuric acid (SSA). The desired products are obtained in good to high yields without any toxic byproducts.
Author details: | Ali Reza SardarianORCiD, Iman Dindarloo Inaloo, Ali Reza Modarresi-AlamORCiD, Erich KleinpeterORCiDGND, Uwe SchildeORCiDGND |
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DOI: | https://doi.org/10.1021/acs.joc.8b02191 |
ISSN: | 0022-3263 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30624064 |
Title of parent work (English): | The journal of organic chemistry |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Year of first publication: | 2019 |
Publication year: | 2019 |
Release date: | 2021/04/07 |
Volume: | 84 |
Issue: | 4 |
Number of pages: | 9 |
First page: | 1748 |
Last Page: | 1756 |
Funding institution: | Research Council of Shiraz University |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |