Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding
- We introduce a novel double-hydrophilic hydroxyethylmethacrylate (HEMA) based diblock glycopolymer which self-assembles into homogeneous spherical micellar structures in water. The micellar structure renders surface-oriented N-acetylglucocosamine (GlcNAc) sugar moieties for strong multivalent glycan-mediated lectin binding. Structural analysis and lectin binding is performed by microscopy methods, dynamic light scattering (DLS) and two-focus fluorescence correlation spectroscopy (2fFCS), revealing a novel micellar type of multivalent sugar binding scaffold with high potential for biomedical applications.
| Author details: | H. Park, S. Walta, Ruben R. RosencrantzORCiDGND, A. Koerner, Christoph SchulteGND, L. Elling, Walter RichteringORCiD, Alexander BökerORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1039/c5py00797f |
| ISSN: | 1759-9954 |
| ISSN: | 1759-9962 |
| Title of parent work (English): | Polymer Chemistry |
| Publisher: | Royal Society of Chemistry |
| Place of publishing: | Cambridge |
| Publication type: | Article |
| Language: | English |
| Year of first publication: | 2016 |
| Publication year: | 2016 |
| Release date: | 2020/03/22 |
| Volume: | 7 |
| Number of pages: | 9 |
| First page: | 878 |
| Last Page: | 886 |
| Funding institution: | Deutsche Forschungsgemeinschaft (DFG) [SFB 985] |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| Peer review: | Referiert |
