Switching enzyme activity by a temperature responsive inhibitor modified polymer
- A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.
Author details: | Falko O. RottkeORCiD, Marie-Victoria HeyneORCiD, Stefan ReinickeORCiDGND |
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DOI: | https://doi.org/10.1039/c9cc09385k |
ISSN: | 1359-7345 |
ISSN: | 1364-548X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31996889 |
Title of parent work (English): | Chemical communications |
Publisher: | Royal Society of Chemistry |
Place of publishing: | Cambridge |
Publication type: | Article |
Language: | English |
Date of first publication: | 2020/01/22 |
Publication year: | 2020 |
Release date: | 2023/03/30 |
Volume: | 56 |
Issue: | 16 |
Number of pages: | 4 |
First page: | 2459 |
Last Page: | 2462 |
Funding institution: | German Science Foundation (DFG)German Research Foundation (DFG) |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |