Switching enzyme activity by a temperature responsive inhibitor modified polymer
- A thermoresponsive NIPAAm-based polymer is combined with the selective acetylcholinesterase inhibitor tacrine in order to create a strict in sense on/off switch for enzymatic activity. This polymer-inhibitor conjugate inhibits AChE at room temperature and enables reactivation of AChE by heating above the cloud point of the conjugate.
| Author details: | Falko O. RottkeORCiD, Marie-Victoria HeyneORCiD, Stefan ReinickeORCiDGND |
|---|---|
| DOI: | https://doi.org/10.1039/c9cc09385k |
| ISSN: | 1359-7345 |
| ISSN: | 1364-548X |
| Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31996889 |
| Title of parent work (English): | Chemical communications |
| Publisher: | Royal Society of Chemistry |
| Place of publishing: | Cambridge |
| Publication type: | Article |
| Language: | English |
| Date of first publication: | 2020/01/22 |
| Publication year: | 2020 |
| Release date: | 2023/03/30 |
| Volume: | 56 |
| Issue: | 16 |
| Number of pages: | 4 |
| First page: | 2459 |
| Last Page: | 2462 |
| Funding institution: | German Science Foundation (DFG)German Research Foundation (DFG) |
| Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
| DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
| Peer review: | Referiert |
