Anna Birukov, Dorte Glintborg, Matthias B. Schulze, Tina K. Jensen, Olga Kuxhaus, Louise B. Andersen, Kristin Kräker, Elli Polemiti, Boye L. Jensen, Jan S. Jørgensen, Ralf Dechend, Marianne S. Andersen
- Objective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings in a population-based cohort of pregnant women, who were stratified according to their metabolic status in early third trimester. Methods: We recorded blood pressure longitudinally during pregnancy in 1230 women from the Odense Child Cohort, Denmark. Fasting glucose and insulin were measured at gestational weeks 28-30. Metabolic status was evaluated according to the WHO 2013 threshold for GDM (GDM-WHO: fasting plasma glucose >= 5.1 mmol/l), insulin and homeostatic model assessment of insulin resistance (HOMA-IR). Relationships between metabolic status in third trimester and blood pressure trajectories were evaluated with adjusted linear mixed models. Trajectory was defined as blood pressure records in pregnancy per 4 weeks interval. Results: Prevalence of GDM-WHO was 40% (498/1230). GDM-WHO was associatedObjective: Hypertension before and during early pregnancy has been associated with an increased risk of gestational diabetes mellitus (GDM) in retrospective analyses. We aimed to investigate the prospective blood pressure trackings in a population-based cohort of pregnant women, who were stratified according to their metabolic status in early third trimester. Methods: We recorded blood pressure longitudinally during pregnancy in 1230 women from the Odense Child Cohort, Denmark. Fasting glucose and insulin were measured at gestational weeks 28-30. Metabolic status was evaluated according to the WHO 2013 threshold for GDM (GDM-WHO: fasting plasma glucose >= 5.1 mmol/l), insulin and homeostatic model assessment of insulin resistance (HOMA-IR). Relationships between metabolic status in third trimester and blood pressure trajectories were evaluated with adjusted linear mixed models. Trajectory was defined as blood pressure records in pregnancy per 4 weeks interval. Results: Prevalence of GDM-WHO was 40% (498/1230). GDM-WHO was associated with 1.46 (0.22-2.70) mmHg higher SBP and 1.04 (0.07-2.01) mmHg higher DBP trajectories in the overall cohort. The associations were driven by differences in the overweight group, with 3.14 (1.05-5.25) mmHg higher SBP and 1.94 (0.42-3.47) mmHg higher DBP per 4 weeks in women with GDM-WHO compared with women without GDM-WHO. GDM-WHO was not associated with blood pressure in women with normal weight. Blood pressure trajectories were elevated across quartiles of insulin resistance. Conclusion: GDM-WHO is associated with higher blood pressure in pregnancy, and there appears to be a stronger effect in overweight women.…
MetadatenAuthor details: | Anna Birukov, Dorte GlintborgORCiD, Matthias B. SchulzeORCiDGND, Tina K. Jensen, Olga Kuxhaus, Louise B. Andersen, Kristin Kräker, Elli Polemiti, Boye L. Jensen, Jan S. Jørgensen, Ralf Dechend, Marianne S. Andersen |
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DOI: | https://doi.org/10.1097/HJH.0000000000003196 |
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ISSN: | 0263-6352 |
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ISSN: | 1473-5598 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/35792096 |
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Title of parent work (English): | Journal of hypertension |
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Publisher: | Lippincott Williams & Wilkins |
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Place of publishing: | Philadelphia |
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Publication type: | Article |
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Language: | English |
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Date of first publication: | 2022/08/01 |
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Publication year: | 2022 |
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Release date: | 2024/07/09 |
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Tag: | WHO; blood pressure; gestational diabetes mellitus; insulin resistance; overweight; pregnancy |
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Volume: | 40 |
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Issue: | 8 |
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Number of pages: | 10 |
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First page: | 1614 |
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Last Page: | 1623 |
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Funding institution: | German Ministry of Education and Research (BMBF); State of Brandenburg; (DZD) [82DZD00302]; Danish Research Council for Strategic Research; (Innovationsfonden) [11-115861]; Region of Southern Denmark [10-15756];; Novo Nordisk Foundation [NNF17OC0028972]; Karen Elise Jensen Foundation;; German Research Foundation (DFG) [DE 631/15-1] |
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Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
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Peer review: | Referiert |
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License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |
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