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Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans
- Background: All living cells display a rapid molecular response to adverse environmental conditions, and the heat shock protein family reflects one such example. Hence, failing to activate heat shock proteins can impair the cellular response. In the present study, we evaluated whether the loss of different isoforms of heat shock protein (hsp) genes in Caenorhabditis elegans would affect their vulnerability to Manganese (Mn) toxicity. Conclusions: Taken together, our data suggest that Mn exposure modulates heat shock protein expression, particularly HSP-70, in C. elegans. Furthermore, loss of hsp-70 increases protein oxidation and dopaminergic neuronal degeneration following manganese exposure, which is associated with the inhibition of pink1 increased expression, thus potentially exacerbating the vulnerability to this metal.
Author details: | Daiana Silva AvilaORCiD, Alexandre Benedetto, Catherine Au, Julia BornhorstORCiDGND, Michael A. Aschner |
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DOI: | https://doi.org/10.1186/s40360-016-0097-2 |
ISSN: | 2050-6511 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/27802836 |
Title of parent work (English): | Plant Methods |
Publisher: | BioMed Central |
Place of publishing: | London |
Publication type: | Article |
Language: | English |
Year of first publication: | 2016 |
Publication year: | 2016 |
Release date: | 2020/03/22 |
Tag: | Caenorhabitis elegans; Heat shock proteins; Manganese; hsp-70; pink1 |
Volume: | 17 |
Number of pages: | 9 |
Funding institution: | DFG [BO 4103/2-1]; CNPq/Universal Grant [453963/2014-5]; National Institute of Environmental Health Sciences (NIEHS) [R01 ES10563, R01 ES07331]; CNPq |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
Peer review: | Referiert |