Selenoneine ameliorates peroxide-induced oxidative stress in C. elegans
- Scope: Selenoneine (2-selenyl-N-alpha, N-alpha, N-alpha-trimethyl-L-histidine), the selenium (Se) analogue of the ubiquitous thiol compound and putative antioxidant ergothioneine, is the major organic selenium species in several marine fish species. Although its antioxidant efficacy has been proposed, selenoneine has been poorly characterized, preventing conclusions on its possible beneficial health effects. Methods and results: Treatment of Caenorhabditis elegans (C. elegans) with selenoneine for 18 h attenuated the induction of reactive oxygen and nitrogen species (RONS). However, the effect was not immediate, occurring 48 h post-treatment. Total Se and Se speciation analysis revealed that selenoneine was efficiently taken up and present in its original form directly after treatment, with no metabolic transformations observed. 48 h posttreatment, total Se in worms was slightly higher compared to controls and no selenoneine could be detected. Conclusion: The protective effect of selenoneine may not be attributed to the presence ofScope: Selenoneine (2-selenyl-N-alpha, N-alpha, N-alpha-trimethyl-L-histidine), the selenium (Se) analogue of the ubiquitous thiol compound and putative antioxidant ergothioneine, is the major organic selenium species in several marine fish species. Although its antioxidant efficacy has been proposed, selenoneine has been poorly characterized, preventing conclusions on its possible beneficial health effects. Methods and results: Treatment of Caenorhabditis elegans (C. elegans) with selenoneine for 18 h attenuated the induction of reactive oxygen and nitrogen species (RONS). However, the effect was not immediate, occurring 48 h post-treatment. Total Se and Se speciation analysis revealed that selenoneine was efficiently taken up and present in its original form directly after treatment, with no metabolic transformations observed. 48 h posttreatment, total Se in worms was slightly higher compared to controls and no selenoneine could be detected. Conclusion: The protective effect of selenoneine may not be attributed to the presence of the compound itself, but rather to the activation of molecular mechanisms with consequences at more protracted time points.…
Author details: | Isabelle RohnORCiDGND, Nina KroepflORCiD, Michael AschnerORCiDGND, Julia BornhorstORCiDGND, Doris KuehneltORCiD, Tanja SchwerdtleORCiDGND |
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DOI: | https://doi.org/10.1016/j.jtemb.2019.05.012 |
ISSN: | 0946-672X |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/31345370 |
Title of parent work (English): | Journal of trace elements in medicine and biology |
Publisher: | Elsevier GMBH |
Place of publishing: | München |
Publication type: | Article |
Language: | English |
Year of first publication: | 2019 |
Publication year: | 2019 |
Release date: | 2020/11/11 |
Tag: | Caenorhabditis elegans; Oxidative stress; Selenium; Selenoneine |
Volume: | 55 |
Number of pages: | 4 |
First page: | 78 |
Last Page: | 81 |
Funding institution: | German Research Foundation (DFG)German Research Foundation (DFG) [SCHW 903/9-1, BO 4103/2-1]; Austrian Science Fund (FWF)Austrian Science Fund (FWF) [I 2262-N28]; DFG Research Unit TraceAgeGerman Research Foundation (DFG) [FOR 2558]; National Institute of Environmental Health SciencesUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [NIEHS R01ES07331, NIEHS R01ES10563, NIEHS R01ES020852] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Ernährungswissenschaft |
DDC classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Peer review: | Referiert |