Formation of DNA-Copolymer Fibrils Through an Amyloid-Like Nucleation Polymerization Mechanism
- Conjugation of a hydrophobic poly(2-oxazoline) bearing tertiary amide groups along its backbone with a short single stranded nucleotide sequence results in an amphiphilic comb/graft copolymer, which organizes in fibrils upon direct dissolution in water. Supported by circular dichroism, atomic force microscopy, transmission electron microscopy, and scattering data, fibrils are formed through inter- and intramolecular hydrogen bonding between hydrogen accepting amide groups along the polymer backbone and hydrogen donating nucleic acid grafts leading to the formation of hollow tubes.
Author details: | Dawid Kedracki, Sergey K. Filippov, Nidhi Gour, Helmut SchlaadORCiDGND, Corinne Nardin |
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DOI: | https://doi.org/10.1002/marc.201400728 |
ISSN: | 1022-1336 |
ISSN: | 1521-3927 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/25704443 |
Title of parent work (English): | Macromolecular rapid communications |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Year of first publication: | 2015 |
Publication year: | 2015 |
Release date: | 2017/03/27 |
Tag: | DNA copolymers; fibers; hydrogen bonding; nucleation polymerization; self-assembly |
Volume: | 36 |
Issue: | 8 |
Number of pages: | 6 |
First page: | 768 |
Last Page: | 773 |
Funding institution: | ESRF; Diamond Light Source; University of Geneva; Swiss National Science Foundation for Research [PPOOP2-12838]; BiostructX [6019]; [INGO LG13058] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |