The physico-chemical basis of DNA radiosensitization
- High-energy radiation is used in combination with radiosensitizing therapeutics to treat cancer. The most common radiosensitizers are halogenated nucleosides and cisplatin derivatives, and recently also metal nanoparticles have been suggested as potential radiosensitizing agents. The radiosensitizing action of these compounds can at least partly be ascribed to an enhanced reactivity towards secondary low-energy electrons generated along the radiation track of the high-energy primary radiation, or to an additional emission of secondary reactive electrons close to the tumor tissue. This is referred to as physico-chemical radiosensitization. In this Concept article we present current experimental methods used to study fundamental processes of physico-chemical radiosensitization and discuss the most relevant classes of radiosensitizers. Open questions in the current discussions are identified and future directions outlined, which can lead to optimized treatment protocols or even novel therapeutic concepts.
Author details: | Robin Mathis SchürmannORCiDGND, Stefanie VogelORCiDGND, Kenny EbelORCiD, Ilko BaldORCiDGND |
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DOI: | https://doi.org/10.1002/chem.201800804 |
ISSN: | 0947-6539 |
ISSN: | 1521-3765 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/29522244 |
Title of parent work (English): | Chemistry - a European journal |
Subtitle (English): | implications for cancer radiation therapy |
Publisher: | Wiley-VCH |
Place of publishing: | Weinheim |
Publication type: | Article |
Language: | English |
Date of first publication: | 2018/03/09 |
Publication year: | 2018 |
Release date: | 2021/10/28 |
Tag: | cancer; dissociative electron attachment; low-energy electrons; radiation therapy; radiosensitizers |
Volume: | 24 |
Issue: | 41 |
Number of pages: | 9 |
First page: | 10271 |
Last Page: | 10279 |
Funding institution: | Federal Institute for Materials Research and Testing (BAM); Deutsche Forschungsgemeinschaft (DFG)German Research Foundation (DFG) [BA 4026/5-2, BA 4026/6-1] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |