- Response inhibition is an attention function which develops relatively early during childhood. Behavioral data suggest that by the age of 3, children master the basic task requirements for the assessment of response inhibition but performance improves substantially until the age of 7. The neuronal mechanisms underlying these developmental processes, however, are not well understood. In this study, we examined brain activation patterns and behavioral performance of children aged between 4 and 6 years compared to adults by applying a go/no-go paradigm during near-infrared spectroscopy (NIRS) brain imaging. We furthermore applied task-independent functional connectivity measures to the imaging data to identify maturation of intrinsic neural functional networks. We found a significant group x condition related interaction in terms of inhibition-related reduced right fronto-parietal activation in children compared to adults. In contrast, motor-related activation did not differ between age groups. Functional connectivity analysis revealedResponse inhibition is an attention function which develops relatively early during childhood. Behavioral data suggest that by the age of 3, children master the basic task requirements for the assessment of response inhibition but performance improves substantially until the age of 7. The neuronal mechanisms underlying these developmental processes, however, are not well understood. In this study, we examined brain activation patterns and behavioral performance of children aged between 4 and 6 years compared to adults by applying a go/no-go paradigm during near-infrared spectroscopy (NIRS) brain imaging. We furthermore applied task-independent functional connectivity measures to the imaging data to identify maturation of intrinsic neural functional networks. We found a significant group x condition related interaction in terms of inhibition-related reduced right fronto-parietal activation in children compared to adults. In contrast, motor-related activation did not differ between age groups. Functional connectivity analysis revealed that in the children's group, short-range coherence within frontal areas was stronger, and long-range coherence between frontal and parietal areas was weaker, compared to adults. Our findings show that in children aged from 4 to 6 years fronto-parietal brain maturation plays a crucial part in the cognitive development of response inhibition.…
MetadatenAuthor details: | Jan Mehnert, Atae Akhrif, Silke Telkemeyer, Sonja Rossi, Christoph H. Schmitz, Jens Steinbrink, Isabell WartenburgerORCiDGND, Hellmuth Obrig, Susanne Neufang |
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DOI: | https://doi.org/10.1016/j.braindev.2012.11.006 |
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ISSN: | 0387-7604 |
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ISSN: | 1872-7131 |
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Title of parent work (English): | Brain and development : official journal of the Japanese Society of Child Neurology |
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Publisher: | Elsevier |
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Place of publishing: | Amsterdam |
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Publication type: | Article |
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Language: | English |
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Year of first publication: | 2013 |
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Publication year: | 2013 |
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Release date: | 2017/03/26 |
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Tag: | Development; Early childhood; Functional connectivity; NIRS; Optical tomography; Response inhibition |
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Volume: | 35 |
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Issue: | 10 |
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Number of pages: | 11 |
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First page: | 894 |
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Last Page: | 904 |
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Funding institution: | Parmenides Foundation - Parmenides Center for the Study of Thinking,
Munich; Bernstein Focus Neurotechnology [BMBF-Fkz 01GQ0850]; German
Federal Ministry of Education and Research; World Class University
Program through the National Research Foundation of Korea; Ministry of
Education, Science, and Technology [R31-10008]; NIH [R42NS050007,
R44NS049734] |
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Organizational units: | Humanwissenschaftliche Fakultät / Strukturbereich Kognitionswissenschaften / Department Linguistik |
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Peer review: | Referiert |
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Institution name at the time of the publication: | Humanwissenschaftliche Fakultät / Institut für Linguistik / Allgemeine Sprachwissenschaft |
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