Betulin-Constituted multiblock amphiphiles for broad-spectrum protein resistance
- Multiblock-like amphiphilic polyurethanes constituted by poly(ethylene oxide) and biosourced betulin are designed for antifouling and synthesized by a convenient organocatalytic route comprising tandem chain-growth and step-growth polymerizations. The doping density of betulin (D-B) in the polymer chain structure is readily varied by a mixed-initiator strategy. The spin-coated polymer films exhibit unique nanophase separation and protein resistance behaviors. Higher D-B leads to enhanced surface hydrophobicity and, unexpectedly, improved protein resistance. It is found that the surface holds molecular-level heterogeneity when D-B is substantially high due to restricted phase separation; therefore, broad-spectrum protein resistance is achieved despite considerable surface hydrophobicity. As D-B decreases, the distance between adjacent betulin units increases so that hydrophobic nanodomains are formed, which provide enough landing areas for relatively small-sized proteins to adsorb on the surface.
Author details: | Ye ChenORCiD, Qilei Song, Junpeng ZhaoORCiD, Xiangjun GongORCiD, Helmut SchlaadORCiDGND, Guangzhao Zhang |
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DOI: | https://doi.org/10.1021/acsami.7b16255 |
ISSN: | 1944-8244 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/29378120 |
Title of parent work (English): | ACS applied materials & interfaces |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Date of first publication: | 2018/02/21 |
Publication year: | 2018 |
Release date: | 2022/01/19 |
Tag: | amphiphilic surface; antifouling; multiblock copolymer; organocatalytic polymerization; renewable resource |
Volume: | 10 |
Issue: | 7 |
Number of pages: | 8 |
First page: | 6593 |
Last Page: | 6600 |
Funding institution: | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21674038, 21734004]; Fundamental Research Funds for Central UniversitiesFundamental Research Funds for the Central Universities [2017ZD072] |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |