DNA origami substrates for highly sensitive surface-enhanced raman scattering
- DNA nanotechnology holds great promise for the fabrication of novel plasmonic nanostructures and the potential to carry out single-molecule measurements using optical spectroscopy. Here, we demonstrate for the first time that DNA origami nanostructures can be exploited as substrates for surface-enhanced Raman scattering (SERS). Gold nanoparticles (AuNPs) have been arranged into dimers to create intense Raman scattering hot spots in the interparticle gaps. AuNPs (15 nm) covered with TAMRA-modified DNA have been placed at a nominal distance of 25 nm to demonstrate the formation of Raman hot spots. To control the plasmonic coupling between the nanoparticles and thus the field enhancement in the hot spot, the size of AuNPs has been varied from 5 to 28 nm by electroless Au deposition. By the precise positioning of a specific number of TAMRA molecules in these hot spots, SERS with the highest sensitivity down to the few-molecule level is obtained.
Author details: | Julia PrinzORCiDGND, Benjamin Schreiber, Lydia OlejkoORCiDGND, Jana Oertel, Jenny RackwitzGND, Adrian KellerORCiD, Ilko BaldORCiDGND |
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DOI: | https://doi.org/10.1021/jz402076b |
ISSN: | 1948-7185 |
Title of parent work (English): | The journal of physical chemistry letters |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Year of first publication: | 2013 |
Publication year: | 2013 |
Release date: | 2017/03/26 |
Volume: | 4 |
Issue: | 23 |
Number of pages: | 6 |
First page: | 4140 |
Last Page: | 4145 |
Funding institution: | Marie Curie FP7 Integration Grant within the 7th European Union Framework Programme; Deutsche Forschungsgemeinschaft (DFG); University of Potsdam; Alexander von Humboldt Foundation |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
Peer review: | Referiert |
Institution name at the time of the publication: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für physikalische Chemie |