A Ratiometric Fluorescent Probe for K+ in Water Based on a Phenylaza-18-Crown-6 Lariat Ether
- This work presents two molecular fluorescent probes 1 and 2 for the selective determination of physiologically relevant K+ levels in water based on a highly K+/Na+ selective building block, the o-(2-methoxyethoxy)phenylaza-18-crown-6 lariat ether unit. Fluorescent probe 1 showed a high K+-induced fluorescence enhancement (FE) by a factor of 7.7 of the anthracenic emission and a dissociation constant (K-d) value of 38mm in water. Further, for 2+K+, we observed a dual emission behavior at 405 and 505nm. K+ increases the fluorescence intensity of 2 at 405nm by a factor of approximately 4.6 and K+ decreases the fluorescence intensity at 505nm by a factor of about 4.8. Fluorescent probe 2+K+ exhibited a K-d value of approximately 8mm in Na+-free solutions and in combined K+/Na+ solution a similar K-d value of about 9mm was found, reflecting the high K+/Na+ selectivity of 2 in water. Therefore, 2 is a promising fluorescent tool to measure ratiometrically and selectively physiologically relevant K+ levels.
Verfasserangaben: | Thomas SchwarzeORCiD, Janine RiemerORCiDGND, Hans-Jürgen HoldtORCiD |
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DOI: | https://doi.org/10.1002/chem.201802306 |
ISSN: | 0947-6539 |
ISSN: | 1521-3765 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/29863303 |
Titel des übergeordneten Werks (Englisch): | Chemistry - a European journal |
Verlag: | Wiley-VCH |
Verlagsort: | Weinheim |
Publikationstyp: | Wissenschaftlicher Artikel |
Sprache: | Englisch |
Datum der Erstveröffentlichung: | 04.06.2018 |
Erscheinungsjahr: | 2018 |
Datum der Freischaltung: | 29.10.2021 |
Freies Schlagwort / Tag: | charge transfer; crown compounds; fluorescence; potassium; ratiometric sensors |
Band: | 24 |
Ausgabe: | 40 |
Seitenanzahl: | 6 |
Erste Seite: | 10116 |
Letzte Seite: | 10121 |
Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer Review: | Referiert |