Anionic polymer brushes for biomimetic calcium phosphate mineralization
- This article describes the synthesis of anionic polymer brushes and their mineralization with calcium phosphate. The brushes are based on poly(3-sulfopropyl methacrylate potassium salt) providing a highly charged polymer brush surface. Homogeneous brushes with reproducible thicknesses are obtained via surface-initiated atom transfer radical polymerization. Mineralization with doubly concentrated simulated body fluid yields polymer/inorganic hybrid films containing AB-Type carbonated hydroxyapatite (CHAP), a material resembling the inorganic component of bone. Moreover, growth experiments using Dictyostelium discoideum amoebae demonstrate that the mineral-free and the mineral-containing polymer brushes have a good biocompatibility suggesting their use as biocompatible surfaces in implantology or related fields.
Author details: | Tobias Mai, Karol WolskiORCiD, Agnieszka Puciul-MalinowskaORCiD, Alexey KopyshevORCiDGND, Ralph GräfORCiDGND, Michael BrunsORCiD, Szczepan ZapotocznyORCiD, Andreas TaubertORCiDGND |
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DOI: | https://doi.org/10.3390/polym10101165 |
ISSN: | 2073-4360 |
Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/30961090 |
Title of parent work (English): | Polymers |
Subtitle (English): | A surface with application potential in biomaterials |
Publisher: | MDPI |
Place of publishing: | Basel |
Publication type: | Article |
Language: | English |
Date of first publication: | 2018/10/18 |
Publication year: | 2018 |
Release date: | 2021/09/20 |
Tag: | Dictyostelium discoideum; biocompatibility; bone mimic; calcium phosphate; carbonated apatite; hydroxyapatite; polymer brushes |
Volume: | 10 |
Issue: | 10 |
Number of pages: | 17 |
Funding institution: | European Science Foundation (Precision Polymer Materials P2M) [4701]; Karlsruhe Micro- and Nano Facility [2015-014-007830]; University of Potsdam; TEAM program of the Foundation for Polish Science - European Union under the European Regional Development Fund [TEAM/2016-1/9]; Federal Ministry of Economics and TechnologyFederal Ministry for Economic Affairs and Energy (BMWi) |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
License (German): | CC-BY - Namensnennung 4.0 International |