Lois M. Muiva-Mutisya, Yoseph Atilaw, Matthias Heydenreich, Andreas Koch, Hoseah M. Akala, Agnes C. Cheruiyot, Matthew L. Brown, Beatrice Irungu, Faith A. Okalebo, Solomon Derese, Charles Mutai, Abiy Yenesew
- The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and mundulinol. The structures were elucidated by the use of NMR spectroscopy and mass spectrometry. The absolute configuration of the flavanonols was determined based on quantum chemical ECD calculations. In the antiplasmodial assay, compound 2 showed the highest activity against chloroquine-sensitive Plasmodiumfalciparum reference clones (D6 and 3D7), artemisinin-sensitive isolate (F32-TEM) as well as field isolate (KSM 009) with IC50 values 1.4-4.6M without significant cytotoxicity against Vero and HEp2 cell lines (IC50>100M). The new compound (1) showed weak antiplasmodial activity, IC50 12.5-24.2M, but also showed selective anticancer activity against HEp2 cell line (CC50 16.9M). [GRAPHICS] .
MetadatenVerfasserangaben: | Lois M. Muiva-Mutisya, Yoseph Atilaw, Matthias HeydenreichORCiD, Andreas KochORCiDGND, Hoseah M. AkalaORCiD, Agnes C. Cheruiyot, Matthew L. Brown, Beatrice Irungu, Faith A. Okalebo, Solomon DereseORCiD, Charles Mutai, Abiy YenesewORCiD |
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DOI: | https://doi.org/10.1080/14786419.2017.1353510 |
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ISSN: | 1478-6419 |
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ISSN: | 1478-6427 |
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Pubmed ID: | https://pubmed.ncbi.nlm.nih.gov/28714338 |
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Titel des übergeordneten Werks (Englisch): | Natural Product Research |
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Verlag: | Routledge, Taylor & Francis Group |
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Verlagsort: | Abingdon |
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Publikationstyp: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Erstveröffentlichung: | 16.07.2018 |
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Erscheinungsjahr: | 2018 |
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Datum der Freischaltung: | 30.03.2022 |
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Freies Schlagwort / Tag: | Leguminosae; Tephrosia subtriflora; antiplasmodial; cytotoxicity; prenylated flavanonol; subtriflavanonol |
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Band: | 32 |
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Ausgabe: | 12 |
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Seitenanzahl: | 8 |
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Erste Seite: | 1407 |
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Letzte Seite: | 1414 |
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Fördernde Institution: | National Commission for Science, Technology and Innovation (NACOSTI), Kenya [NCST/ST&I/RCD/4TH CALL PhD/090]; International Science Programme [KEN-02] |
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Organisationseinheiten: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
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DDC-Klassifikation: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
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Peer Review: | Referiert |
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