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Scaling Up UV-Mediated Intramolecular Photodehydro-Diels-Alder Reactions Using a Homemade High-Performance Annular Continuous-Flow Reactor
- Here we present a self-made annular continuous-flow reactor that can be used in the UV/vis range in an internal numbering-up manner. As a model reaction, we chose a powerful batch-scale-limited benzoannelation method, namely, an intramolecular photodehydro-Diels-Alder (IMPDDA) reaction. The scale-up potential of this particular photochemical benchmark reaction toward the preparation of macrocylic (1,7)naphthalenophanes by variation of selected flow parameters is presented.
Author details: | Maciej CzarneckiORCiD, Pablo WessigORCiDGND |
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DOI: | https://doi.org/10.1021/acs.oprd.8b00353 |
ISSN: | 1083-6160 |
ISSN: | 1520-586X |
Title of parent work (English): | Organic Process Research & Development |
Publisher: | American Chemical Society |
Place of publishing: | Washington |
Publication type: | Article |
Language: | English |
Date of first publication: | 2018/11/20 |
Publication year: | 2018 |
Release date: | 2021/01/13 |
Tag: | flow photochemistry; photocycloaddition; photodehydro-Diels-Alder reaction; scale-up |
Volume: | 22 |
Issue: | 12 |
Number of pages: | 5 |
First page: | 1823 |
Last Page: | 1827 |
Funding institution: | Deutsche Forschungsgemeinschaft |
Organizational units: | Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie |
DDC classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
Peer review: | Referiert |
License (German): | Keine öffentliche Lizenz: Unter Urheberrechtsschutz |