Poly(alpha-Peptoid)s Revisited: Synthesis, Properties, and Use as Biomaterial

  • Polypeptoids have been of great interest in the polymer science community since the early half of the last century; however, they had been basically forgotten materials until the last decades in which they have enjoyed an exciting revival. In this mini-review, we focus on the recent developments in polypeptoid chemistry, with particular focus on polymers synthesized by the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs). Specifically, we will review traditional monomer synthesis (such as Leuchs, Katchalski, and Kricheldorf) and recent advances in polymerization methods to yield both linear, cyclic, and functional polymers, solution and bulk thermal properties, and preliminary results on the use of polypeptoids as biomaterials (i.e immunogenicity, biodistribution, degradability, and drug delivery).

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Author:Christian Secker, Sarah M. Brosnan, Robert Luxenhofer, Helmut SchlaadORCiDGND
ISSN:1616-5187 (print)
ISSN:1616-5195 (online)
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=25851782
Parent Title (English):Macromolecular bioscience
Place of publication:Weinheim
Document Type:Article
Year of first Publication:2015
Year of Completion:2015
Release Date:2017/03/27
Tag:amino acid N-carboxyanhydride (NCA); biomaterials; peptides; properties; ring-opening polymerization
First Page:881
Last Page:891
Funder:Max Planck Society; National Science Foundation Postdoctoral Research Fellowship in Biology [DBI-1308104]
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Chemie
Peer Review:Referiert