100 Philosophie und Psychologie
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BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.
METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.
RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).
CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
BACKGROUND: The orbitofrontal cortex (OFC) is implicated in depression. The hypothesis investigated was whether the OFC sensitivity to reward and nonreward is related to the severity of depressive symptoms.
METHODS: Activations in the monetary incentive delay task were measured in the IMAGEN cohort at ages 14 years (n = 1877) and 19 years (n = 1140) with a longitudinal design. Clinically relevant subgroups were compared at ages 19 (high-severity group: n = 116; low-severity group: n = 206) and 14.
RESULTS: The medial OFC exhibited graded activation increases to reward, and the lateral OFC had graded activation increases to nonreward. In this general population, the medial and lateral OFC activations were associated with concurrent depressive symptoms at both ages 14 and 19 years. In a stratified high-severity depressive symptom group versus control group comparison, the lateral OFC showed greater sensitivity for the magnitudes of activations related to nonreward in the high-severity group at age 19 (p = .027), and the medial OFC showed decreased sensitivity to the reward magnitudes in the high-severity group at both ages 14 (p = .002) and 19 (p = .002). In a longitudinal design, there was greater sensitivity to nonreward of the lateral OFC at age 14 for those who exhibited high depressive symptom severity later at age 19 (p = .003).
CONCLUSIONS: Activations in the lateral OFC relate to sensitivity to not winning, were associated with high depressive symptom scores, and at age 14 predicted the depressive symptoms at ages 16 and 19. Activations in the medial OFC were related to sensitivity to winning, and reduced reward sensitivity was associated with concurrent high depressive symptom scores.
Theodor Lessing was a German-Jewish philosopher, Zionist, Communist and member of the Prager Kreis. He wrote psychological studies of Judaism and influenced with his main philosophical works Geschichte als Sinngebung des Sinnlosen (1919) and Europa und Asien (1918, and 1924) the German speaking scholars and contemporaries in Germany and elsewhere. He was killed by the Nazis in 1933 as one of the first victims of National Socialism.
I argue that Hegel’s Logic traces an emergent-purposive, logical method that entails two key identities in reason. These identities are (1) between a logic of freedom and necessity, and (2) between the possibilities of a priori and a posteriori reasoning in a purposive method. The purposive method of the Logic is the basis for these identities and, in Hegel’s view, facilitates the transition from Kant’s transcendental idealism to absolute idealism. I suggest that this method is Hegel’s attempt to rework a critique of philosophy according to Kant’s insight about the principle grounding the formal purposiveness of the faculties, what Hegel calls, “one of Kant’s greatest services to philosophy.”
Introduction
(2021)
Kant wrote in the Critique of Pure Reason, “For the law of reason to seek unity is necessary, since without it we would have no reason, and without that, no coherent use of the understanding, and, lacking that, no sufficient mark of empirical truth.” This unity of reason, taken as a holistic condition, was central to the convictions of the idealists. To them, Kant layed bare the right path forward, but also fundamental failings in his execution of a critique of reason which needed to be overcome in order for reason to secure its own, internal end. In this chapter, I discuss key themes in the positive inheritance of Kant’s thought in classical German philosophy and offer an overview of the arguments and significances of each contribution to this volume. The aim is not to minimize important differences between Kant and post-Kantian Idealists, but rather to emphasize core retentions of Kant’s thought.
Scholarship on German Idealism typically couches the systems of Idealism in terms of a rejection of or departure from Kant's critical philosophy. The few accounts that do look to the positive influence of Kant on the Idealists typically focus on the perceived need among the Idealists to revise Kant's system due to various shortcomings arising from his dualism. This volume seeks to reverse this norm. It does this by bringing together an original set of critical reflections on the ways in which the German Idealists maintain specific and fundamental Kantian qualities in their own systems. At the same time, the aim of this volume is not a reduction of German Idealism to Kant's thought. Instead, this volume highlights a set of core ways in which the German Idealists retain specific, fundamentally Kantian principles and qualities. To that extent, this volume paves the way for new interpretations by laying the ground for identifying those significant components of German Idealism that can defensibly be called "Kantian.
Jenseits der Klinik
(2021)
Unser Beitrag stellt ein interaktives Ethik-Konzept vor, das in Zusammenarbeit der BruderhausDiakonie Reutlingen und der Universität Tübingen entwickelt wurde, um den Eigenheiten und Bedarfen einer komplexen Organisationsstruktur gerecht zu werden, die mehrere Geschäftsfelder und Standorte unter sich vereint. Wir skizzieren die Grundzüge des interaktiven Nijmegener Modells, in dem die Kooperation eines auf Leitungsebene angesiedelten Komitees und situationsbezogener Fallbesprechungen ein fruchtbares Zusammenspiel zweier unverzichtbarer Reflexionsweisen bewirken soll („Top-Down“/„Bottom-Up“). Wir zeigen auf, welche Herausforderungen sich bei der Implementierung dieses Modells in die konkrete Aufbauorganisation der BruderhausDiakonie ergaben, und mit welchen konzeptionellen oder „implementationstechnischen“ Mitteln ihnen begegnet wurde. Im Zentrum steht dabei die Erweiterung des Nijmegener Modells um ein Verbindungselement, welches die Zusammenarbeit zwischen zentralem Ausschuss und dezentralen Fallbesprechungen koordiniert und das interaktive Moment des Modells erst ermöglicht.