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The warm water geothermal reservoir below the village of Waiwera in New Zealand has been known by the native Maori for centuries. Development by the European immigrants began in 1863. Until the year 1969, the warm water flowing from all drilled wells was artesian. Due to overproduction, water up to 50 A degrees C now needs to be pumped to surface. Further, between 1975 and 1976, all warm water seeps on the beach of Waiwera ran dry. Within the context of sustainable water management, hydrogeological models must be developed as part of a management plan. Approaches of varying complexity have been set-up and applied since the 1980s. However, none of the models directly provide all results required for optimal water management. Answers are given simply to parts of the questions, nonetheless improving resource management of the geothermal reservoir.
Targeted capture coupled with high-throughput sequencing can be used to gain information about nuclear sequence variation at hundreds to thousands of loci. Divergent reference capture makes use of molecular data of one species to enrich target loci in other (related) species. This is particularly valuable for nonmodel organisms, for which often no a priori knowledge exists regarding these loci. Here, we have used targeted capture to obtain data for 809 nuclear coding DNA sequences (CDS) in a nonmodel organism, the Eurasian lynx Lynx lynx, using baits designed with the help of the published genome of a related model organism (the domestic cat Felis catus). Using this approach, we were able to survey intraspecific variation at hundreds of nuclear loci in L. lynx across the species’ European range. A large set of biallelic candidate SNPs was then evaluated using a high-throughput SNP genotyping platform (Fluidigm), which we then reduced to a final 96 SNP-panel based on assay performance and reliability; validation was carried out with 100 additional Eurasian lynx samples not included in the SNP discovery phase. The 96 SNP-panel developed from CDS performed very successfully in the identification of individuals and in population genetic structure inference (including the assignment of individuals to their source population). In keeping with recent studies, our results show that genic SNPs can be valuable for genetic monitoring of wildlife species.
Multi-component (MC) diffusion simulations enable a process based and more precise approach to calculate transport and sorption compared to the commonly used single-component (SC) models following Fick's law. The MC approach takes into account the interaction of chemical species in the porewater with the diffuse double layer (DDL) adhering clay mineral surfaces. We studied the shaly, sandy and carbonate-rich facies of the Opalinus Clay. High clay contents dominate diffusion and sorption of uranium. The MC simulations show shorter diffusion lengths than the SC models due to anion exclusion from the DDL. This hampers diffusion of the predominant species CaUO2(CO3)32-. On the one side, species concentrations and ionic strengths of the porewater and on the other side surface charge of the clay minerals control the composition and behaviour of the DDL. For some instances, it amplifies the diffusion of uranium. We developed a workflow to transfer computationally intensive MC simulations to SC models via calibrated effective diffusion and distribution coefficients. Simulations for one million years depict maximum uranium diffusion lengths between 10 m and 35 m. With respect to the minimum requirement of a thickness of 100 m, the Opalinus Clay seems to be a suitable host rock for nuclear waste repositories.
Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.
Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic–pituitary–adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.
Leaching zones within potash seams generally represent a significant risk to subsurface mining operations and the construction of technical caverns in salt rocks, but their temporal and spatial formation has been investigated only rudimentarily to date. To the knowledge of the authors, current reactive transport simulation implementations are not capable to address hydraulic-chemical interactions within potash salt. For this reason, a reactive transport model has been developed and complemented by an innovative approach to calculate the interchange of minerals and solution at the water-rock interface. Using this model, a scenario analysis was carried out based on a carnallite-bearing potash seam. The results show that the evolution of leaching zones depends on the mineral composition and dissolution rate of the original salt rock, and that the formation can be classified by the dimensionless parameters of Peclet (Pe) and Damkohler (Da). For Pe > 2 and Da > 1, a funnel-shaped leaching zone is formed, otherwise the dissolution front is planar. Additionally, Da > 1 results in the formation of a sylvinitic zone and a flow barrier. Most scenarios represent hybrid forms of these cases. The simulated shapes and mineralogies are confirmed by literature data and can be used to assess the hazard potential.
Diffusive transport and sorption processes of uranium in the Swiss Opalinus Clay were investigated as a function of partial pressure of carbon dioxide pCO(2), varying mineralogy in the facies and associated changes in porewater composition. Simulations were conducted in one-dimensional diffusion models on the 100 m-scale for a time of one million years using a bottom-up approach based on mechanistic surface complexation models as well as cation exchange to quantify sorption. Speciation calculations have shown, uranium is mainly present as U(VI) and must therefore be considered as mobile for in-situ conditions. Uranium migrated up to 26 m in both, the sandy and the carbonate-rich facies, whereas in the shaly facies 16 m was the maximum. The main species was the anionic complex CaUO2(CO3)(3)(2-) . Hence, anion exclusion was taken into account and further reduced the migration distances by 30 %. The concentrations of calcium and carbonates reflected by the set pCO(2) determine speciation and activity of uranium and consequently the sorption behaviour. Our simulation results allow for the first time to prioritize on the far-field scale the governing parameters for diffusion and sorption of uranium and hence outline the sensitivity of the system. Sorption processes are controlled in descending priority by the carbonate and calcium concentrations, pH, pe and the clay mineral content. Therefore, the variation in porewater composition resulting from the heterogeneity of the facies in the Opalinus Clay formation needs to be considered in the assessment of uranium migration in the far field of a potential repository.
Computation of the instantaneous phase and amplitude via the Hilbert Transform is a powerful tool of data analysis. This approach finds many applications in various science and engineering branches but is not proper for causal estimation because it requires knowledge of the signal’s past and future. However, several problems require real-time estimation of phase and amplitude; an illustrative example is phase-locked or amplitude-dependent stimulation in neuroscience. In this paper, we discuss and compare three causal algorithms that do not rely on the Hilbert Transform but exploit well-known physical phenomena, the synchronization and the resonance. After testing the algorithms on a synthetic data set, we illustrate their performance computing phase and amplitude for the accelerometer tremor measurements and a Parkinsonian patient’s beta-band brain activity.
Computation of the instantaneous phase and amplitude via the Hilbert Transform is a powerful tool of data analysis. This approach finds many applications in various science and engineering branches but is not proper for causal estimation because it requires knowledge of the signal’s past and future. However, several problems require real-time estimation of phase and amplitude; an illustrative example is phase-locked or amplitude-dependent stimulation in neuroscience. In this paper, we discuss and compare three causal algorithms that do not rely on the Hilbert Transform but exploit well-known physical phenomena, the synchronization and the resonance. After testing the algorithms on a synthetic data set, we illustrate their performance computing phase and amplitude for the accelerometer tremor measurements and a Parkinsonian patient’s beta-band brain activity.
Quantifying rock weakening due to decreasing calcite mineral content by numerical simulations
(2018)
The quantification of changes in geomechanical properties due to chemical reactions is of paramount importance for geological subsurface utilisation, since mineral dissolution generally reduces rock stiffness. In the present study, the effective elastic moduli of two digital rock samples, the Fontainebleau and Bentheim sandstones, are numerically determined based on micro-CT images. Reduction in rock stiffness due to the dissolution of 10% calcite cement by volume out of the pore network is quantified for three synthetic spatial calcite distributions (coating, partial filling and random) using representative sub-cubes derived from the digital rock samples. Due to the reduced calcite content, bulk and shear moduli decrease by 34% and 38% in maximum, respectively. Total porosity is clearly the dominant parameter, while spatial calcite distribution has a minor impact, except for a randomly chosen cement distribution within the pore network. Moreover, applying an initial stiffness reduced by 47% for the calcite cement results only in a slightly weaker mechanical behaviour. Using the quantitative approach introduced here substantially improves the accuracy of predictions in elastic rock properties compared to general analytical methods, and further enables quantification of uncertainties related to spatial variations in porosity and mineral distribution.
Quantifying rock weakening due to decreasing calcite mineral content by numerical simulations
(2018)
The quantification of changes in geomechanical properties due to chemical reactions is of paramount importance for geological subsurface utilisation, since mineral dissolution generally reduces rock stiffness. In the present study, the effective elastic moduli of two digital rock samples, the Fontainebleau and Bentheim sandstones, are numerically determined based on micro-CT images. Reduction in rock stiffness due to the dissolution of 10% calcite cement by volume out of the pore network is quantified for three synthetic spatial calcite distributions (coating, partial filling and random) using representative sub-cubes derived from the digital rock samples. Due to the reduced calcite content, bulk and shear moduli decrease by 34% and 38% in maximum, respectively. Total porosity is clearly the dominant parameter, while spatial calcite distribution has a minor impact, except for a randomly chosen cement distribution within the pore network. Moreover, applying an initial stiffness reduced by 47% for the calcite cement results only in a slightly weaker mechanical behaviour. Using the quantitative approach introduced here substantially improves the accuracy of predictions in elastic rock properties compared to general analytical methods, and further enables quantification of uncertainties related to spatial variations in porosity and mineral distribution.
Predicting macroscopic elastic rock properties requires detailed information on microstructure
(2017)
Predicting variations in macroscopic mechanical rock behaviour due to microstructural changes, driven by mineral precipitation and dissolution is necessary to couple chemo-mechanical processes in geological subsurface simulations. We apply 3D numerical homogenization models to estimate Young’s moduli for five synthetic microstructures, and successfully validate our results for comparable geometries with the analytical Mori-Tanaka approach. Further, we demonstrate that considering specific rock microstructures is of paramount importance, since calculated elastic properties may deviate by up to 230 % for the same mineral composition. Moreover, agreement between simulated and experimentally determined Young’s moduli is significantly improved, when detailed spatial information are employed.
The Renewable energy power generation capacity has been rapidly increasing in China recently. Meanwhile, the contradiction between power supply and demand is becoming increasingly more prominent due to the intermittence of renewable energies. On the other hand, on the mitigation of carbon dioxide (CO2) emissions in China needs immediate attention. Power-to-Gas (PtG), a chemical energy storage technology, can convert surplus electricity into combustible gases. Subsurface energy storage can meet the requirements of long term storage with its large capacity. This paper provides a discussion of the entire PtG energy storage technology process and the current research progress. Based on the comparative study of different geological storage schemes for synthetic methane, their respective research progress and limitations are noted. In addition, a full investigation of the distribution and implementation of global PtG and CO2 capture and storage (CCS) demonstration projects is performed. Subsequently, the opportunities and challenges of the development of this technology in China are discussed based on techno-economic and ecological effects analysis. While PtG is expected to be a revolutionary technology that will replace traditional power systems, the main issues of site selection, energy efficiency and the economy still need to be adequately addressed. Additionally, based on the comprehensive discussion of the results of the analysis, power-to-gas and subsurface energy storage implementation strategies, as well as outlook in China are presented.
Transport properties of potential host rocks for nuclear waste disposal are typically determined in laboratory or in-situ experiments under geochemically controlled and constant conditions. Such a homogeneous assumption is no longer applicable on the host rock scale as can be seen from the pore water profiles of the potential host rock Opalinus Clay at Mont Terri (Switzerland). The embedding aquifers are the hydro-geological boundaries, that established gradients in the 210 m thick low permeable section through diffusive exchange over millions of years. Present-day pore water profiles were confirmed by a data-driven as well as by a conceptual scenario. Based on the modelled profiles, the influence of the geochemical gradient on uranium migration was quantified by comparing the distances after one million years with results of common homogeneous models. Considering the heterogeneous system, uranium migrated up to 24 m farther through the formation depending on the source term position within the gradient and on the partial pressure of carbon dioxide pCO2 of the system. Migration lengths were almost equal for single- and multicomponent diffusion. Differences can predominantly be attributed to changes in the sorption capacity, whereby pCO2 governs how strong uranium migration is affected by the geochemical gradient. Thus, the governing parameters for uranium migration in the Opalinus Clay can be ordered in descending priority: pCO2, geochemical gradients, mineralogical heterogeneity.</p>
POET (v0.1): speedup of many-core parallel reactive transport simulations with fast DHT lookups
(2021)
Coupled reactive transport simulations are extremely demanding in terms of required computational power, which hampers their application and leads to coarsened and oversimplified domains. The chemical sub-process represents the major bottleneck: its acceleration is an urgent challenge which gathers increasing interdisciplinary interest along with pressing requirements for subsurface utilization such as spent nuclear fuel storage, geothermal energy and CO2 storage. In this context we developed POET (POtsdam rEactive Transport), a research parallel reactive transport simulator integrating algorithmic improvements which decisively speed up coupled simulations. In particular, POET is designed with a master/worker architecture, which ensures computational efficiency in both multicore and cluster compute environments. POET does not rely on contiguous grid partitions for the parallelization of chemistry but forms work packages composed of grid cells distant from each other. Such scattering prevents particularly expensive geochemical simulations, usually concentrated in the vicinity of a reactive front, from generating load imbalance between the available CPUs (central processing units), as is often the case with classical partitions. Furthermore, POET leverages an original implementation of the distributed hash table (DHT) mechanism to cache the results of geochemical simulations for further reuse in subsequent time steps during the coupled simulation. The caching is hence particularly advantageous for initially chemically homogeneous simulations and for smooth reaction fronts. We tune the rounding employed in the DHT on a 2D benchmark to validate the caching approach, and we evaluate the performance gain of POET's master/worker architecture and the DHT speedup on a 3D benchmark comprising around 650 000 grid elements. The runtime for 200 coupling iterations, corresponding to 960 simulation days, reduced from about 24 h on 11 workers to 29 min on 719 workers. Activating the DHT reduces the runtime further to 2 h and 8 min respectively. Only with these kinds of reduced hardware requirements and computational costs is it possible to realistically perform the longterm complex reactive transport simulations, as well as perform the uncertainty analyses required by pressing societal challenges connected with subsurface utilization.
Wissenschaftliche Artikel: Sabine Boehlich “Nisters Nay-gayst. Der Schriftsteller als Zaddik” Juliane Rösch „Di berliner hobn nisht gegloybt zeyere oygn“. Das jiddischsprachige Theater GOSET und der Regisseur Alexander Granovsky Anne-Christin Saß „Wenn die Nazi-Verbrecher nach Hause kommen” – Dovid Eynhorns Berichte über die nationalsozialistischen Verbrechen im New Yorker Forverts 1940-1945 Rebekka Denz Der „Froyenvinkl“ : Die Frauenrubrik in der bundischen Tageszeitung „Naye Folkstsaytung“ Nathanael Riemer Some parallels of stories in Glikls of Hameln Zikhroynes Jiddisch aus aller Welt: Holger Nath The First Yiddish Summer Program in Birobidzhan (August 13-August 30, 2007) Satoko Kamoshida A woman and a language: In the case of a Yiddish speaker in Israel Arturo Kerbel “Dear brother! Where from are you coming?” A brief history of the Yiddish language and culture in Mexiko Kazuo Ueda Jiddischforschung in Japan Essay: Elvira Grözinger Die Deutsche Bahn und die Krux mit dem Gedenken Tagungsberichte: “Zwischenräume”. Jüdisch-christliche Lebenswelten unter venezianischer Herrschaft im späten Mittelalter und der frühen Neuzeit. Venedig, Deutsches Studienzentrum und Dipartimento di Studi Storici der Universität Ca’ Foscari, 5.9.-7.9. 2007. (Daniel Jütte) “Global Forum for Combating Antisemitism”, Israelisches Außenministerium, Jerusalem, 24.-25.2. 2008. (Clemens Heni) Rezensionen: Arno Herzig/Cay Rademacher (Hg.): Die Geschichte der Juden in Deutschland (Robert Jütte) Georg Bossong: Die Sepharden. Geschichte und Kultur der spanischen Juden (Rafael Arnold) Barbara Staudinger: Die jüdische Welt und die Wittelsbacher (Daniel Jütte) Leon Modena: Jüdische Riten, Sitten und Gebräuche. Hg., übersetzt und kommentiert von Rafael Arnold (Karl E. Grözinger) Kenneth Stow: An Image and Its Interpreters. Continuity in the Catholic-Jewish Encounter (Elvira Grözinger) Aldina Quintana Rodríguez: Geografía Lingüística del Judeoespañol. Estudio sincrónico y diacrónico (Rafael Arnold) Wolfgang Vogt: Moses Mendelssohns Beschreibung der Wirklichkeit menschlichen Erkennens (Grazyna Jurewicz) Stefan Müller-Doohm (Hg.): Adorno-Portraits. Erinnerungen von Zeitgenossen (Michael Dallapiazza) Andrea Löw: Juden im Getto Litzmannstadt. Lebensbedingungen, Selbstwahrnehmung, Verhalten. Die Chronik des Gettos Lodz/Litzmannstadt. Hg. v. Sascha Feuchert, Erwin Leibfried, Jörg Riecke (Maria Kühn-Ludewig) Eglè Bendikaitè: Sionistinis sajudis Lietuvoje. Litauisches Historisches Institut (Elvira Grözinger) Barbara Staudinger (Hg.): Von Bayern nach Erez Israel. Auf den Spuren jüdischer Volkskunst. From Bavaria to Eretz Israel. Tracing Jewish Folk Art (Anat Feinberg) Hugh Denman (Hg.): Isaac Bashevis Singer: His Work and His World (Elvira Grözinger) Annkatrin Dahm: Der Topos der Juden. Studien zur Geschichte des Antisemitismus im deutschsprachigen Musikschrifttum (Daniel Jütte) Max Peter Baumann/Tim Becker/Raphael Woebs (Hg.): Musik und Kultur im jüdischen Leben der Gegenwart (Joel E. Rubin)
PaRDeS : Zeitschrift der Vereinigung für Jüdische Studien e.V. = 100jähriges Jubiläum Tel Avivs
(2009)
Aus dem Editorial: "Seit Anfang April diesen Jahres feiert Tel Aviv sein 100jähriges Jubiläum. Bei über 400 verschiedenartigsten Veranstaltungen in dieser israelischen Stadt und in unzähligen Orten außerhalb Israels wird 2009 über deren Geschichte resümiert, reflektiert sowie (kritisch) diskutiert. Dabei wird nicht nur die Geschichte der Stadt thematisiert, sondern gerade auch die Gegenwart und insbesondere deren Zukunft. Aus diesem Anlass weist die diesjährige Ausgabe von PaRDeS den Themenschwerpunkt 100 Jahre Tel Aviv /100th anniversary of Tel Aviv auf. Israelische, (zeitweise) in Tel Aviv oder in anderen Ländern tätige Wissenschaftlerinnen und Wissenschaftler nähern sich aus mitunter sehr unterschiedlichen Perspektiven und Wissensbereichen der Geschichte und Gegenwart dieser größten israelischen Stadt. Anita Shapira eröffnet mit Tel Aviv, a White City on the Sands den insgesamt sieben Artikel umfassenden Themenschwerpunkt. In ihrem Beitrag umreißt sie die Entstehungsgeschichte der israelischen Großstadt bis zur Gründung des Staates Israel 1948. Shapira geht dabei insbesondere auf zionistische Ideen bei der Stadtgründung und deren (stellenweise nicht) erfolgte Realisierung ein. In den 1920er und 30er Jahren wird das modernisierte Hebräisch zur Triebfeder bei der Herausbildung einer neuen säkular-jüdischen Kultur in Palästina. Innerhalb dieses Prozesses nimmt gerade die jungen Metropole Tel Aviv eine bedeutende Rolle ein. Philipp Messner beschreibt in seinem Beitrag Tel Aviv und die Revolution des hebräischen Schriftbilds diese Umwälzungen auf der graphisch-ästhetischen Ebene des hebräischen Schriftbildes. In ihrem Artikel Von der Einwanderung der Jekim zu ihrer politischen Partizipation bei den Wahlen zum Tel Aviver Stadtrat im Jahr 1936 zeigt Sarah Wittkopf anhand des Publikationsorgans Mitteilungsblatt der Irgun Olej Merkas Europa welchen Widerständen die Einwanderer aus den deutschsprachigen Ländern bei der Mitgestaltung der Politik in Palästina ausgesetzt waren. Im Zentrum der Auseinandersetzungen in Tel Aviv steht der Spitzenkandidat der Einwandererorganisation Felix Rosenblüth. Im vierten Artikel Building a Modern Jewish City: Projects of the Architect Wilhelm Zeev Haller in Tel Aviv stellt Ulrich Knufinke Kontinuitätslinien und -brüche im architektonischen Schaffen Wilhelm Zeev Hallers zwischen Europa und Tel Aviv dar." [die Herausgeber] PaRDeS, die Zeitschrift der Vereinigung für Jüdische Studien e.V., möchte die fruchtbare und facettenreiche Kultur des Judentums sowie seine Berührungspunkte zur Umwelt in den unterschiedlichen Bereichen dokumentieren. Daneben dient die Zeitschrift als Forum zur Positionierung der Fächer Jüdische Studien und Judaistik innerhalb des wissenschaftlichen Diskurses sowie zur Diskussion ihrer historischen und gesellschaftlichen Verantwortung.
Barite stands out as one of the most ubiquitous scaling agents in deep geothermal systems, responsible for irreversible efficiency loss. Due to complex parameter interplay, it is imperative to utilise numerical simulations to investigate temporal and spatial precipitation effects. A one-dimensional reactive transport model is set up with heterogeneous nucleation and crystal growth kinetics. In line with geothermal systems in the North German Basin, the following parameters are considered in a sensitivity analysis: temperature (25 to 150 degrees C), pore pressure (10 to 50 MPa), fracture aperture (10(-4) to 10(-2) m), flow velocity (10(-3) to 10(0) m s(-1)), molar volume (50.3 to 55.6 cm(3) mol(-1)), contact angle for heterogeneous nucleation (0 degrees to 180 degrees), interfacial tension (0.07 to 0.134 J m(-2)), salinity (0.1 to 1.5 mol kgw(-1) NaCl), pH (5 to 7), and supersaturation ratio (1 to 30). Nucleation and consequently crystal growth can only begin if the threshold supersaturation is exceeded, therefore contact angle and interfacial tension are the most sensitive in terms of precipitation kinetics. If nucleation has occurred, crystal growth becomes the dominant process, which is mainly controlled by fracture aperture. Results show that fracture sealing takes place within months (median 33 days) and the affected range can be on the order of tens of metres (median 10 m). The presented models suggest that barite scaling must be recognised as a serious threat if the supersaturation threshold is exceeded, in which case, large fracture apertures could help to minimise kinetic rates. The models further are of use for adjusting the fluid injection temperature.
Water management tools are necessary to guarantee the preservation of natural resources while ensuring optimum utilization. Linear regression models are a simple and quick solution for creating prognostic capabilities. Multivariate models show higher precision than univariate models. In the case of Waiwera, implementation of individual production rates is more accurate than applying just the total production rate. A maximum of approximately 1,075 m3/day can be pumped to ensure a water level of at least 0.5 m a.s.l. in the monitoring well. The model should be renewed annually to implement new data and current water level trends to keep the quality.
Mammalian arachidonic acid lipoxygenases (ALOXs) have been implicated in cell differentiation and in the pathogenesis of inflammation. The mouse genome involves seven functional Alox genes and the encoded enzymes share a high degree of amino acid conservation with their human orthologs. There are, however, functional differences between mouse and human ALOX orthologs. Human ALOX15B oxygenates arachidonic acid exclusively to its 15-hydroperoxy derivative (15S-HpETE), whereas 8S-HpETE is dominantly formed by mouse Alox15b. The structural basis for this functional difference has been explored and in vitro mutagenesis humanized the reaction specificity of the mouse enzyme. To explore whether this mutagenesis strategy may also humanize the reaction specificity of mouse Alox15b in vivo, we created Alox15b knock-in mice expressing the arachidonic acid 15-lipoxygenating Tyr603Asp+His604Val double mutant instead of the 8-lipoxygenating wildtype enzyme. These mice are fertile, display slightly modified plasma oxylipidomes and develop normally up to an age of 24 weeks. At later developmental stages, male Alox15b-KI mice gain significantly less body weight than outbred wildtype controls, but this effect was not observed for female individuals. To explore the possible reasons for the observed gender-specific growth arrest, we determined the basic hematological parameters and found that aged male Alox15b-KI mice exhibited significantly attenuated red blood cell parameters (erythrocyte counts, hematocrit, hemoglobin). Here again, these differences were not observed in female individuals. These data suggest that humanization of the reaction specificity of mouse Alox15b impairs the functionality of the hematopoietic system in males, which is paralleled by a premature growth arrest.