EDTA and NTA effectively tune the mineralization of calcium phosphate from bulk aqueous solution

  • This study describes the effects of nitrilotriacetic acid (NTA) and ethylenediaminotetraacetic acid (EDTA) on themineralization of calciumphosphate from bulk aqueous solution. Mineralization was performed between pH 6 and 9 and with NTA or EDTA concentrations of 0, 5, 10, and 15 mM. X-ray diffraction and infrared spectroscopy show that at low pH, mainly brushite precipitates and at higher pH, mostly hydroxyapatite forms. Both additives alter the morphology of the precipitates. Without additive, brushite precipitates as large plates. With NTA, the morphology changes to an unusual rod-like shape. With EDTA, the edges of the particles are rounded and disk-like particles form. Conductivity and pH measurements suggest that the final products form through several intermediate steps.

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Metadaten
Author details:Doreen HentrichORCiDGND, Klaus TauerORCiD, Montserrat Espanol, Maria-Pau GinebraORCiD, Andreas TaubertORCiDGND
DOI:https://doi.org/10.3390/biomimetics2040024
ISSN:2313-7673
Pubmed ID:https://pubmed.ncbi.nlm.nih.gov/31105185
Title of parent work (English):Biomimetics
Publisher:MDPI
Place of publishing:Basel
Publication type:Article
Language:English
Year of first publication:2017
Publication year:2017
Release date:2020/05/15
Tag:EDTA; NTA; biomimetic mineralization; biomineralization; brushite; calcium phosphate; hydroxyapatite; precipitation
Volume:2
Issue:4
Number of pages:21
Funding institution:University of Potsdam; Max Planck Institute of Colloids and Interfaces
Organizational units:Mathematisch-Naturwissenschaftliche Fakultät / Institut für Biochemie und Biologie
Peer review:Referiert
Publishing method:Open Access
Open Access / Gold Open-Access
DOAJ gelistet
License (German):License LogoCC-BY - Namensnennung 4.0 International
External remark:Zweitveröffentlichung in der Schriftenreihe Postprints der Universität Potsdam : Mathematisch-Naturwissenschaftliche Reihe ; 1095
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