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- Adenylyl cyclase (1)
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Observations of the young supernova remnant RX J1713.7-3946 with the fermi large area telescope
(2011)
We present observations of the young supernova remnant (SNR) RX J1713.7-3946 with the Fermi Large Area Telescope (LAT). We clearly detect a source positionally coincident with the SNR. The source is extended with a best-fit extension of 0 degrees.55 +/- 0 degrees.04 matching the size of the non-thermal X-ray and TeV gamma-ray emission from the remnant. The positional coincidence and the matching extended emission allow us to identify the LAT source with SNR RX J1713.7-3946. The spectrum of the source can be described by a very hard power law with a photon index of Gamma = 1.5 +/- 0.1 that coincides in normalization with the steeper H. E. S. S.-detected gamma-ray spectrum at higher energies. The broadband gamma-ray emission is consistent with a leptonic origin as the dominant mechanism for the gamma-ray emission.
The origin of Galactic cosmic rays is a century-long puzzle. Indirect evidence points to their acceleration by supernova shockwaves, but we know little of their escape from the shock and their evolution through the turbulent medium surrounding massive stars. Gamma rays can probe their spreading through the ambient gas and radiation fields. The Fermi Large Area Telescope (LAT) has observed the star-forming region of Cygnus X. The 1- to 100-gigaelectronvolt images reveal a 50-parsec-wide cocoon of freshly accelerated cosmic rays that flood the cavities carved by the stellar winds and ionization fronts from young stellar clusters. It provides an example to study the youth of cosmic rays in a superbubble environment before they merge into the older Galactic population.
Ga1-xMnxAs, x=0.043, has been grown ex situ on GaAs(100) by low-temperature molecular-beam epitaxy. On the reprepared p(1x1) surface, resonant photoemission of the valence band shows a 20-fold enhancement of the Mn 3d contribution at the L-3 edge. The difference spectrum is similar to our previously obtained resonant photoemission at the Mn M edge, in particular a strong satellite appears and no clear Fermi edge ruling out strong Mn 3d weight at the valence-band maximum. The x-ray absorption lineshape differs from previous publications. Our calculation based on a configuration-interaction cluster model reproduces the x-ray absorption and the L-3 on-resonance photoemission spectrum for model parameters Delta, U-dd, and (pdsigma) consistent with our previous work and shows the same spectral shape on and off resonance thus rendering resonant photoemission measured at the L-3 edge representative of the Mn 3d contribution. At the same time, the results are more bulk sensitive due to a probing depth about twice as large as for photoemission at the Mn M edge. The confirmation of our previous results obtained at the M edge calls recent photoemission results into question which report the absence of the satellite and good agreement with local-density theory
Dealing with predicted increases in extreme weather conditions due to climate change requires robust knowledge about controls on rainfall-triggered landslides. We explore relationships between rainfall and landslide size throughout the Japanese archipelago. We test whether the total volume of landslides can be predicted directly from rainfall totals, intensity, and duration using a nationwide inventory of 4744 rainfall-triggered landslides recorded from A.D. 2001 to 2011. We find that larger landslides were more abundant at the expense of smaller ones when total, maximum, and mean rainfall intensity exceeded similar to 250 mm, similar to 35 mm/h, and similar to 4 mm/h, respectively. Frequency distributions of these rainfall parameters are peaked and heavily skewed. Yet neither the most frequent nor the most extreme values of these rainfall metrics coincide consistently with the maximum landslide volumes. A striking decrease of landslide volumes at both mean and maximum rainfall intensity, as well as duration, points to an exhaustion in hillslope geomorphic response regardless of sample size, landslide type, mobilized volume, dominant lithology, or reporting bias. Our results underscore substantial offsets between the peaks of rainfall metrics and maximum associated landslide volumes, thus complicating straightforward estimates of geomorphic work from metrics of rainstorm magnitude or frequency. Only the rainfall total appears to be a suitable monotonic predictor of landslide volumes mobilized during typhoons and frontal storms.
The main scope of the InterPACIFIC (Intercomparison of methods for site parameter and velocity profile characterization) project is to assess the reliability of in-hole and surface-wave methods, used for estimating shear wave velocity. Three test-sites with different subsurface conditions were chosen: a soft soil, a stiff soil and a rock outcrop. This paper reports the surface-wave methods results. Specifically 14 teams of expert users analysed the same experimental surface-wave datasets, consisting of both passive and active data. Each team adopted their own strategy to retrieve the dispersion curve and the shear-wave velocity profile at each site. Despite different approaches, the dispersion curves are quite in agreement with each other. Conversely, the shear-wave velocity profiles show a certain variability that increases in correspondence of major stratigraphic interfaces. This larger variability is mainly due to non-uniqueness of the solution and lateral variability. As expected, the observed variability in V-s,V-30 estimatesis small, as solution non-uniqueness plays a limited role. (C) 2015 Elsevier Ltd. All rights reserved.
gamma-aminobutyric acid (GABA) is the predominant inhibitory neurotransmitter in the central nervous system (CNS). Its effects are mediated by either ionotropic GABA(A) receptors or metabotropic GABA(B) receptors. GABA(B) receptors regulate, via Gi/o, G-proteins, ion channels, and adenylyl cyclases. In humans, GABA(B) receptor subtypes are involved in the etiology of neurologic and psychiatric disorders. In arthropods, however, these members of the G-protein-coupled receptor family are only inadequately characterized. Interestingly, physiological data have revealed important functions of GABA(B) receptors in the American cockroach, Periplaneta americana. We have cloned cDNAs coding for putative GABA(B) receptor subtypes 1 and 2 of P. americana (PeaGB1 and PeaGB2). When both receptor proteins are co-expressed in mammalian cells, activation of the receptor heteromer with GABA leads to a dose-dependent decrease in cAMP production. The pharmacological profile differs from that of mammalian and Drosophila GABA(B) receptors. Western blot analyses with polyclonal antibodies have revealed the expression of PeaGB1 and PeaGB2 in the CNS of the American cockroach. In addition to the widespread distribution in the brain, PeaGB1 is expressed in salivary glands and male accessory glands. Notably, PeaGB1-like immunoreactivity has been detected in the GABAergic salivary neuron 2, suggesting that GABA(B) receptors act as autoreceptors in this neuron.