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Objectives: Severe pneumonia may evoke acute lung injury, and sphingosine-1-phosphate is involved in the regulation of vascular permeability and immune responses. However, the role of sphingosine-1-phosphate and the sphingosine-1-phosphate producing sphingosine kinase 1 in pneumonia remains elusive. We examined the role of the sphingosine-1-phosphate system in regulating pulmonary vascular barrier function in bacterial pneumonia. Design: Controlled, in vitro, ex vivo, and in vivo laboratory study. Subjects: Female wild-type and SphK1-deficient mice, 8-10 weeks old. Human postmortem lung tissue, human blood-derived macrophages, and pulmonary microvascular endothelial cells. Interventions: Wild-type and SphK1-deficient mice were infected with Streptococcus pneumoniae. Pulmonary sphingosine-1-phosphate levels, messenger RNA expression, and permeability as well as lung morphology were analyzed. Human blood-derived macrophages and human pulmonary microvascular endothelial cells were infected with S. pneumoniae. Transcellular electrical resistance of human pulmonary microvascular endothelial cell monolayers was examined. Further, permeability of murine isolated perfused lungs was determined following exposition to sphingosine-1-phosphate and pneumolysin. Measurements and Main Results: Following S. pneumoniae infection, murine pulmonary sphingosine-1-phosphate levels and sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 expression were increased. Pneumonia-induced lung hyperpermeability was reduced in SphK1(-/-) mice compared with wild-type mice. Expression of sphingosine kinase 1 in macrophages recruited to inflamed lung areas in pneumonia was observed in murine and human lungs. S. pneumoniae induced the sphingosine kinase 1/sphingosine-1-phosphate system in blood-derived macrophages and enhanced sphingosine-1-phosphate receptor 2 expression in human pulmonary microvascular endothelial cell in vitro. In isolated mouse lungs, pneumolysin-induced hyperpermeability was dose dependently and synergistically increased by sphingosine-1-phosphate. This sphingosine-1-phosphate-induced increase was reduced by inhibition of sphingosine-1-phosphate receptor 2 or its downstream effector Rho-kinase. Conclusions: Our data suggest that targeting the sphingosine kinase 1-/sphingosine-1-phosphate-/sphingosine-1-phosphate receptor 2-signaling pathway in the lung may provide a novel therapeutic perspective in pneumococcal pneumonia for prevention of acute lung injury.
Global change, especially land-use intensification, affects human well-being by impacting the delivery of multiple ecosystem services (multifunctionality). However, whether biodiversity loss is a major component of global change effects on multifunctionality in real-world ecosystems, as in experimental ones, remains unclear. Therefore, we assessed biodiversity, functional composition and 14 ecosystem services on 150 agricultural grasslands differing in land-use intensity. We also introduce five multifunctionality measures in which ecosystem services were weighted according to realistic land-use objectives. We found that indirect land-use effects, i.e. those mediated by biodiversity loss and by changes to functional composition, were as strong as direct effects on average. Their strength varied with land-use objectives and regional context. Biodiversity loss explained indirect effects in a region of intermediate productivity and was most damaging when land-use objectives favoured supporting and cultural services. In contrast, functional composition shifts, towards fast-growing plant species, strongly increased provisioning services in more inherently unproductive grasslands.
Context
For a given body mass index (BMI), both impaired metabolic health (MH) and reduced cardiorespiratory fitness (CRF) associate with increased risk of cardiovascular disease (CVD).
Objective
It remains unknown whether both risk phenotypes relate to CVD independently of each other, and whether these relationships differ in normal weight, overweight, and obese subjects.
Methods
Data from 421 participants from the Tubingen Diabetes Family Study, who had measurements of anthropometrics, metabolic parameters, CRF (maximal aerobic capacity [VO2max]) and carotid intima-media thickness (cIMT), an early marker of atherosclerosis, were analyzed. Subjects were divided by BMI and MH status into 6 phenotypes.
Results
In univariate analyses, older age, increased BMI, and a metabolic risk profile correlated positively, while insulin sensitivity and VO2max negatively with cIMT. In multivariable analyses in obese subjects, older age, male sex, lower VO2max (std. ss -0.21, P = 0.002) and impaired MH (std. ss 0.13, P = 0.02) were independent determinants of increased cIMT. After adjustment for age and sex, subjects with metabolically healthy obesity (MHO) had higher cIMT than subjects with metabolically healthy normal weight (MHNW; 0.59 +/- 0.009 vs 0.52 +/- 0.01 mm; P < 0.05). When VO2max was additionally included in this model, the difference in cIMT between MHO and MHNW groups became statistically nonsignificant (0.58 +/- 0.009 vs 0.56 +/- 0.02 mm; P > 0.05).
Conclusion
These data suggest that impaired MH and low CRF independently determine increased cIMT in obese subjects and that low CRF may explain part of the increased CVD risk observed in MHO compared with MHNW.
Species diversity promotes the delivery of multiple ecosystem functions (multifunctionality). However, the relative functional importance of rare and common species in driving the biodiversity multifunctionality relationship remains unknown. We studied the relationship between the diversity of rare and common species (according to their local abundances and across nine different trophic groups), and multifunctionality indices derived from 14 ecosystem functions on 150 grasslands across a land use intensity (LUI) gradient. The diversity of above- and below-ground rare species had opposite effects, with rare above-ground species being associated with high levels of multifunctionality, probably because their effects on different functions did not trade off against each other. Conversely, common species were only related to average, not high, levels of multifunctionality, and their functional effects declined with LUI. Apart from the community level effects of diversity, we found significant positive associations between the abundance of individual species and multifunctionality in 6% of the species tested. Species specific functional effects were best predicted by their response to LUI: species that declined in abundance with land use intensification were those associated with higher levels of multifunctionality. Our results highlight the importance of rare species for ecosystem multifunctionality and help guiding future conservation priorities.
Aus dem Inhalt dieser Ausgabe: BEITRÄGE: Tania Ünlüdag-Puschnerat: "Wir sind keine bloße Söldnerarmee." Cromwells Revolutionsarmee 1645-49 Peter Blastenbrei: Literaten und Soldaten. Die Militärkritik der deutschen Aufklärung (Teil 1) PROJEKTE: Gabriele Haug-Moritz: "Geschwinde Welt". Krieg und öffentliche Kommunikatrion 1542-1554 Iris Becker: Militär und Aufklärung - Die Rolle der Soldatenbibliotheken im militärischen Bildungs- und Reformprozess Stephan Schwenke: Stadt und Militär - Armee und Bevölkerung. Untersuchungen zu hessischen Festungs- und Garnisonsstädten Malte Prietzel: Mittelalterliche Kriegsgeschichte als Kulturgeschichte Ewa Herfordt/Heidi Mehrkens: Frankreich und Deutschland im Krieg. Zur Kulturgeschichte der europäischen "Erbfeindschaft" Kieron Kleinert: Dialog oder Konfrontation? Der Rat der Stadt Leipzig - sein Verhältnis zu Universität und Garnison BERICHTE: Norbert Winnige: Protokoll der Mitgliederversammlung des AMG Stefan Kroll: Tagungsbericht: Militär und Religiosität in der Frühen Neuzeit Gerhard Sälter: Legislationspraxis in der Vormoderne. Bericht über die 5. Tagung des APO REZENSIONEN: Sascha Möbius: Constantin Hruschka, Kriegsführung und Geschichtsschreibung im Spätmittelalter. Eine Untersuchung zur Chronistik der Konzilszeit, Köln et al. 2001 Uwe Tresp: Stephan Selzer, Deutsche Söldner im Italien des Trecento, Tübingen: Niemeyer, 2001 Matthias Franz: Söldnerleben am Vorabend des Dreißigjährigen Krieges, hrsg. und bearbeitet von Holger Th. Gräf. Mit Beiträgen von Sven Externbrink und Ralf Pröve, Marburg a. d. Lahn 2000 Thomas Fuchs: Was ist Militärgeschichte?, hrsg. von Thomas Kühne und Benjamin Ziemann in Verbindung mit dem Arbeitskreis Mili-tärgeschichte e. V. und dem Institut für soziale Bewegungen der Ruhr-Universität Bochum, Paderborn, München, Wien, Zürich: Ferdinand Schöningh 2000
Three-dimensional bouyancy-driven convection in a horizontal fluid layer with stress-free boundary conditions at the top and bottom and periodic boundary conditions in the horizontal directions is investigated by means of numerical simulation and bifurcation-analysis techniques. The aspect ratio is fixed to a value of 2√2 and the Prandtl number to a value of 6.8. Two-dimensional convection rolls are found to be stable up to a Rayleigh number of 17 950, where a Hopf bifurcation leads to traveling waves. These are stable up to a Rayleigh number of 30 000, where a secondary Hopf bifurcation generates modulated traveling waves. We pay particular attention to the symmetries of the solutions and symmetry breaking by the bifurcations.
We investigate numerically the appearance of heteroclinic behavior in a three-dimensional, buoyancy-driven fluid layer with stress-free top and bottom boundaries, a square horizontal periodicity with a small aspect ratio, and rotation at low to moderate rates about a vertical axis. The Prandtl number is 6.8. If the rotation is not too slow, the skewed-varicose instability leads from stationary rolls to a stationary mixed-mode solution, which in turn loses stability to a heteroclinic cycle formed by unstable roll states and connections between them. The unstable eigenvectors of these roll states are also of the skewed-varicose or mixed-mode type and in some parameter regions skewed-varicose like shearing oscillations as well as square patterns are involved in the cycle. Always present weak noise leads to irregular horizontal translations of the convection pattern and makes the dynamics chaotic, which is verified by calculating Lyapunov exponents. In the nonrotating case, the primary rolls lose, depending on the aspect ratio, stability to traveling waves or a stationary square pattern. We also study the symmetries of the solutions at the intermittent fixed points in the heteroclinic cycle.
Aus dem Inhalt dieser Ausgabe: BEITRÄGE: Peter H. Wilson: British and american perspectives on early modern warfare Mikko Huhtamies: Kriegswesen und Gesellschaft in der frühen Neuzeit in der finnisch-schwedischen Geschichtsforschung INTERNET: Stephan Huck: Nutzungsmöglichkeiten des Internets Gundula Gahlen , Michael Herrmann, Torsten F. Reimer und Norbert Winnige: Militärgeschichte der Frühen Neuzeit im Internet Die Online-Angebote des AMG und sfn Markus Pöhlmann: Die Internetpräsenz des Arbeitskreises Militärgeschichte e.V. Josef Pauser: Das Online-Angebot des Arbeitskreises .Policey/Polizei im vormodernen Europa. Torsten F. Reimer: Eine Studie in Kriegführung. Eine Vorstellung des H-War Military History Network PROJEKTE: Antje Fuchs: Ein neuer Konfessionskrieg? Erfahrungen von Krieg und Okkupation im Kurfürstentum Hannover und benachbarten geistlichen Fürstentümern zur Zeit des Siebenjährigen Krieges 1756-1763 Sascha Möbius: Ergebnisse der Magisterarbeit .Psychologische Aspekte friederizianischer Taktik im Siebenjährigen Krieg. Wolfgang Heil: Die Gemeinen Soldaten. Das Sozialleben der militärischen Unterschicht im altpreußischen Heer und seine Stellung in der altständischen Gesellschaft. Rainer Jacobs: Militärische Dienstpflichten in der Frühen Neuzeit Michael Kaiser und Stefan Kroll: Forschungsprojekt Militär und Religiosität in der Frühen Neuzeit Ralf Blank: Die Schlosskanonen von Hohenlimburg Artilleriegeschütze mit einer wechselvollen Geschichte Gundula Gahlen und Olaf Gründel: Kataster zur Schlacht bei Wittstock von 1636 Jan Schlürmann: Die Schleswig-Holstein-Gottorfischen Auxiliairtruppen im Spanischen Erbfolgekrieg . Ergebnisse einer Untersuchung BERICHTE: Renko Geffarth: Die besetzte res publica. Zum Verhältnis von ziviler Obrigkeit und militärischer Herrschaft in besetzten Gebieten vom Spätmittelalter bis zum 18. Jahrhundert. Gundula Bavendamm: Operationsgeschichte und moderne Historiographie. Ein Widerspruch?