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Die Lifespan-Forschung untersucht die Entwicklung von Individuen über den gesamten Lebenslauf. Die medizinische Rehabilitation hat nach geltendem Sozialrecht die Aufgabe, chronische Krankheiten abzuwenden, zu beseitigen, zu mindern, auszugleichen, eine Verschlimmerung zu verhüten und Negativfolgen für die Lebensführung zu reduzieren. Dies erfordert in wissenschaftlicher wie in praxisbezogener Hinsicht die Entwicklung einer Lebensspannenperspektive als Voraussetzung für die Klassifikation und Diagnostik chronischer Erkrankungen, die Beschreibung von verlaufsbeeinflussenden Faktoren, kritischen Lebensphasen und Critical Incidents (kritische Verlaufszeitpunkte), die Durchführung von prophylaktischen Maßnahmen, die Entwicklung von Assessmentverfahren zur Erfassung und Bewertung von Verläufen oder Vorbehandlungen, die Auswahl und Priorisierung von Interventionen, eine Behandlungs- und Behandlerkoordination auf der Zeitachse, die Präzisierung der Aufgabenstellung für spezialisierte Rehabilitationsmaßnahmen, wie beispielsweise Rehabilitationskliniken, und als Grundlage für die Sozialmedizin. Aufgrund der Vielfalt der individuellen Risikokonstellationen, Krankheitsverläufe und Behandlungssituationen über die Lebensspanne hinweg, bedarf es in der medizinischen Rehabilitation in besonderer Weise einer personalisierten Medizin, die zugleich rehabilitationsförderliche und -behindernde Umweltfaktoren im Rehabilitationsverlauf berücksichtigt.
Interdisziplinäres Zentrum für Musterdynamik und Angewandte Fernerkundung Workshop vom 9. - 10. Februar 2006
Driven mostly by the search for chemical syntheses under biocompatible conditions, so called "click" chemistry rapidly became a growing field of research. The resulting simple one-pot reactions are so far only scarcely accompanied by an adequate optimization via comparably straightforward and robust analysis techniques possessing short set-up times. Here, we report on a fast and reliable calibration-free online NMR monitoring approach for technical mixtures. It combines a versatile fluidic system, continuous-flow measurement of H-1 spectra with a time interval of 20 s per spectrum, and a robust, fully automated algorithm to interpret the obtained data. As a proof-of-concept, the thiol-ene coupling between N-boc cysteine methyl ester and ally] alcohol was conducted in a variety of non-deuterated solvents while its time-resolved behaviour was characterized with step tracer experiments. Overlapping signals in online spectra during thiol-ene coupling could be deconvoluted with a spectral model using indirect hard modeling and were subsequently converted to either molar ratios (using a calibration free approach) or absolute concentrations (using 1-point calibration). For various solvents the kinetic constant k for pseudo-first order reaction was estimated to be 3.9 h(-1) at 25 degrees C. The obtained results were compared with direct integration of non-overlapping signals and showed good agreement with the implemented mass balance. (C) 2017 Elsevier Inc. All rights reserved.
Detailed organic geochemical and carbon isotopic (delta C-13 and Delta C-14) analyses are performed on permafrost deposits affected by coastal erosion (Herschel Island, Canadian Beaufort Sea) and adjacent marine sediments (Herschel Basin) to understand the fate of organic carbon in Arctic nearshore environments. We use an end-member model based on the carbon isotopic composition of bulk organic matter to identify sources of organic carbon. Monte Carlo simulations are applied to quantify the contribution of coastal permafrost erosion to the sedimentary carbon budget. The models suggest that similar to 40% of all carbon released by local coastal permafrost erosion is efficiently trapped and sequestered in the nearshore zone. This highlights the importance of sedimentary traps in environments such as basins, lagoons, troughs, and canyons for the carbon sequestration in previously poorly investigated, nearshore areas.
Plain Language Summary Increasing air and sea surface temperatures at high latitudes leads to accelerated thaw, destabilization, and erosion of perennially frozen soils (i.e., permafrost), which are often rich in organic carbon. Coastal erosion leads to an increased mobilization of organic carbon into the Arctic Ocean, which there can be converted into greenhouse gases and may therefore contribute to further warming. Carbon decomposition can be limited if organic matter is efficiently deposited on the seafloor, buried in marine sediments, and thus removed from the short-term carbon cycle. Basins, canyons, and troughs near the coastline can serve as sediment traps and potentially accommodate large quantities of organic carbon along the Arctic coast. Here we use biomarkers (source-specific molecules), stable carbon isotopes, and radiocarbon to identify the sources of organic carbon in the nearshore zone of the southern Canadian Beaufort Sea near Herschel Island. We quantify the contribution of coastal permafrost erosion to the sedimentary carbon budget of the area and estimate that more than a third of all carbon released by local permafrost erosion is efficiently trapped in marine sediments. This highlights the importance of regional sediment traps for carbon sequestration.