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The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia
(2019)
The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.
We analyze the light curve of the microlensing event OGLE-2003-BLG-175/MOA-2003-BLG-45 and show that it has two properties that, when combined with future high-resolution astrometry, could lead to a direct, accurate measurement of the lens mass. First, the light curve shows clear signs of distortion due to the Earth's accelerated motion, which yields a measurement of the projected Einstein radius (r) over tilde (E). Second, from precise astrometric measurements, we show that the blended light in the event is coincident with the microlensed source to within about 15 mas. This argues strongly that this blended light is the lens and hence opens the possibility of directly measuring the lens- source relative proper motion mu(rel) and so the mass M=(c(2)/4G)mu(rel)t(E)(r) over tilde (E), where t(E) is the measured Einstein timescale. While the light-curve-based measurement of (r) over tildeE is, by itself, severely degenerate, we show that this degeneracy can be completely resolved by measuring the direction of proper motion mu(rel)