Refine
Year of publication
Document Type
- Article (15)
- Monograph/Edited Volume (2)
- Other (2)
- Postprint (2)
- Part of Periodical (1)
Is part of the Bibliography
- yes (22)
Keywords
In der Studie werden 3 Programmvarianten zur Förderung der Selbstregulation vorgestellt (ein emotional orientiertes, ein metakognitiv-bereichsunspezifisches und ein metakognitiv bereichsspezifisches Programm). Trainiert wurden zögerlich-unsichere und impulsive Kinder im mittleren Schulalter. Wir konnten differentielle Wirkungen hinsichtlich Programmvariante und Personengruppe zeigen. Die Wirkungen beziehen sich z. B. auf kognitive Leistungen, das Zielsetzungsverhalten und das durch die Lehrer beobachtete selbstregulative Verhalten im Unterricht.
Berichtet wird über Evaluationsergebnisse zu zwei neuen Trainingsprogrammen für das Lernhandeln. Das erste war motivationalen Schwerpunkten (Zielsetzungsverhalten u.a.) gewidmet. Das zweite diente der Förderung der Metakognition bei der Realisierung von Lernhandlungen. Beide Trainings erwiesen sich als effektiv. Die Wirkungen wurden dadurch bestimmt, wie die Programme den Schülern Leistungszuversicht vermittelten. Beim metakognitiven Realisierungstraining geschah das vorwiegend durch Stärkung der Kontrollerfahrung, beim motivationalen durch verbesserte Zielklärung. Diese Potenzen kamen bei den Schülergruppen mit impulsivem versus zögerlichem Lernverhalten differentiell zur Geltung.
The dimensions of unfolded and intrinsically disordered proteins are highly dependent on their amino acid composition and solution conditions, especially salt and denaturant concentration. However, the quantitative implications of this behavior have remained unclear, largely because the effective theta-state, the central reference point for the underlying polymer collapse transition, has eluded experimental determination. Here, we used single-molecule fluorescence spectroscopy and two-focus correlation spectroscopy to determine the theta points for six different proteins. While the scaling exponents of all proteins converge to 0.62 +/- 0.03 at high denaturant concentrations, as expected for a polymer in good solvent, the scaling regime in water strongly depends on sequence composition. The resulting average scaling exponent of 0.46 +/- 0.05 for the four foldable protein sequences in our study suggests that the aqueous cellular milieu is close to effective theta conditions for unfolded proteins. In contrast, two intrinsically disordered proteins do not reach the T-point under any of our solvent conditions, which may reflect the optimization of their expanded state for the interactions with cellular partners. Sequence analyses based on our results imply that foldable sequences with more compact unfolded states are a more recent result of protein evolution.
The inner region of the Milky Way halo harbors a large amount of dark matter (DM). Given its proximity, it is one of the most promising targets to look for DM. We report on a search for the annihilations of DM particles using gamma-ray observations towards the inner 300 pc of the Milky Way, with the H.E.S.S. array of ground-based Cherenkov telescopes. The analysis is based on a 2D maximum likelihood method using Galactic Center (GC) data accumulated by H.E.S.S. over the last 10 years (2004-2014), and does not show any significant gamma-ray signal above background. Assuming Einasto and Navarro-Frenk-White DM density profiles at the GC, we derive upper limits on the annihilation cross section <sigma nu >. These constraints are the strongest obtained so far in the TeV DM mass range and improve upon previous limits by a factor 5. For the Einasto profile, the constraints reach <sigma nu > values of 6 x 10(-26) cm(3) s(-1) in the W+W- channel for a DM particle mass of 1.5 TeV, and 2 x 10(-26) cm(3) s(-1) in the tau(+)tau(-) channel for a 1 TeV mass. For the first time, ground-based gamma-ray observations have reached sufficient sensitivity to probe <sigma nu > values expected from the thermal relic density for TeV DM particles.