Refine
Has Fulltext
- no (1)
Year of publication
- 2009 (1) (remove)
Document Type
- Article (1)
Language
- English (1)
Is part of the Bibliography
- yes (1)
Institute
All stereoisomers of the natural product centrolobine are selectively synthesized, by starting from a common precursor. Key steps are an enantioselective allylation with enantiomerically pure allylsilanes, a tandem ring-closing metathesis-isomerization reaction, and a Heck reaction by using an arene diazonium salt. By choosing appropriate conditions for the final deprotection step, either the cis-configured centrolobines or their epimers are selectively obtained.