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Factory Innovation Award
(2023)
Einmal mehr brachte die Hannover Messe die Spitzen der Industrie zusammen, um die wegweisenden Innovationen des Jahres mit dem begehrten Factory Innovation Award 2023 zu ehren. Dieser renommierte Preis, der erstmals auf der Industrial Transformation Stage verliehen wurde, markierte den Höhepunkt einer spannungsgeladenen Veranstaltung.
Editorial
(2021)
Berufsbildung für nachhaltige Entwicklung (BBNE) ist (nicht nur) für die Berufs- und Wirtschaftspädagogik ein komplexes, anregendes Forschungsfeld. Zugleich stellt sie für die Lehrer:innenbildung eine herausfordernde Orientierungsaufgabe dar. Dabei kann eine Transdisziplinarität als Basis gemeinsamer Forschungs- und Erkenntnisprozesse der Berufs- und Wirtschaftspädagogik und der Praxis als unumgängliche Voraussetzung zur Annäherung an eine BBNE angesehen werden. Ein Weg, der zukünftigen Berufsschullehrkräften einen praxisorientierten Zugang zur BBNE eröffnen kann, wird in dieser Ausgabe der bwp-Schriften aus unterschiedlichen Perspektiven beschrieben.
Teen dating violence
(2021)
Das Projekt beschäftigt sich mit der visuellen Wirkungsdimension von Lyrik und der Möglichkeit ihrer analytischen Beschreibung. Dafür werden die Anordnung von Versen und Wörtern, Auszeichnungen und andere typographische Strukturen von nicht experimentellen Gedichten seit Ende des 18. Jahrhunderts im Rahmen von Modellanalysen untersucht.
Von Koscher bis Frutarismus
(2024)
Kochbücher à la religion
(2024)
Background:
Inflammatory bowel disease (IBD) represents a dysregulation of the mucosal immune system. The pathogenesis of Crohn’s disease (CD) and ulcerative colitis (UC) is linked to the loss of intestinal tolerance and barrier function. The healthy mucosal immune system has previously been shown to be inert against food antigens. Since the small intestine is the main contact surface for antigens and therefore the immunological response, the present study served to analyse food-antigen-specific T cells in the peripheral blood of IBD patients.
Methods:
Peripheral blood mononuclear cells of CD, with an affected small intestine, and UC (colitis) patients, either active or in remission, were stimulated with the following food antigens: gluten, soybean, peanut and ovalbumin. Healthy controls and celiac disease patients were included as controls. Antigen-activated CD4+ T cells in the peripheral blood were analysed by a magnetic enrichment of CD154+ effector T cells and a cytometric antigen-reactive T-cell analysis (‘ARTE’ technology) followed by characterisation of the ef- fector response.
Results:
The effector T-cell response of antigen-specific T cells were compared between CD with small intestinal inflammation and UC where inflammation was restricted to the colon. Among all tested food antigens, the highest frequency of antigen-specific T cells (CD4+CD154+) was found for gluten. Celiac disease patients were included as control, since gluten has been identified as the disease- causing antigen. The highest frequency of gluten antigen-specific T cells was revealed in active CD when compared with UC, celiac disease on a gluten-free diet (GFD) and healthy controls. Ovalbuminspecific T cells were almost undetectable, whereas the reaction to soybean and peanut was slightly higher. But again, the strong- est reaction was observed in CD with small intestinal involvement compared with UC. Remarkably, in celiac disease on a GFD only
antigen-specific cells for gluten were detected. These gluten-specific T cells were characterised by up-regulation of the pro-inflammatory cytokines IFN-γ, IL-17A and TNF-α. IFN-g was exclusively elevated in CD patients with active disease. Gluten-specific T-cells expressing IL-17A were increased in all IBD patients. Furthermore, T cells of CD patients, independent of disease activity, revealed a high expression of the pro-inflammatory cytokine TNF-α.
Conclusion:
The ‘ARTE’-technique allows to analyse and quantify food antigen specific T cells in the peripheral blood of IBD patients indicating a potential therapeutic insight. These data provide evidence that small intestinal inflammation in CD is key for the development of a systemic pro-inflammatory effector T-cell response driven by food antigens.
Most flowering plants are hermaphrodites, with flowers having both male and female reproductive organs. One widespread adaptation to limit self-fertilization is self-incompatibility (SI), where self-pollen fails to fertilize ovules.(1,2) In homomorphic SI, many morphologically indistinguishable mating types are found, although in heteromorphic SI, the two or three mating types are associated with different floral morphologies.(3-6) In heterostylous Primula, a hemizygous supergene determines a short-styled S-morph and a long-styled L-morph, corresponding to two different mating types, and full seed set only results from inter morph crosses.(7-9) Style length is controlled by the brassinosteroid (BR)-inactivating cytochrome P450 CYP734A50,(10) yet it remains unclear what defines the male and female incompatibility types. Here, we show that CYP734A50 also determines the female incompatibility type. Inactivating CYP734A50 converts short S-morph styles into long styles with the same incompatibility behavior as L-morph styles, and this effect can be mimicked by exogenous BR treatment. In vitro responses of S-and L-morph pollen grains and pollen tubes to increasing BR levels could only partly explain their different in vivo behavior, suggesting both direct and indirect effects of the different BR levels in S-versus L-morph stigmas and styles in controlling pollen performance. This BR-mediated SI provides a novel mechanism for preventing self-fertilization. The joint control of morphology and SI by CYP734A50 has important implications for the evolutionary buildup of the heterostylous syndrome and provides a straightforward explanation for why essentially all of the derived self-compatible homostylous Primula species are long homostyles.(11)
Editorial
(2020)
Einführung in die Tagung
(2015)
Grußwort des Dekans
(2015)
Reinhard Hujer
(2020)
Xenikoudakis et al. report a partial mitochondrial genome of the extinct giant beaver Castoroides and estimate the origin of aquatic behavior in beavers to approximately 20 million years. This time estimate coincides with the extinction of terrestrial beavers and raises the question whether the two events had a common cause.
Corona-Lage
(2020)
Künstliche Intelligenz (KI) gewinnt in zahlreichen Branchen rasant an Bedeutung und wird zunehmend auch in Enterprise Resource Planning (ERP)-Systemen als Anwendungsbereich erschlossen. Die Idee, dass Maschinen die kognitiven Fähigkeiten des Menschen imitieren können, indem Wissen durch Lernen auf Basis von Beispielen in Daten, Informationen und Erfahrungen generiert wird, ist heute ein Schlüsselelement der digitalen Transformation. Jedoch charakterisiert der Einsatz von KI in ERP-System einen hohen Komplexitätsgrad, da die KI als Querschnittstechnologie zu verstehen ist, welche in unterschiedlichen Unternehmensbereichen zum Einsatz kommen kann. Auch die Anwendungsgrade können sich dabei erheblich voneinander unterscheiden. Um trotz dieser Komplexität den Einsatz der KI in ERP-Systemen erfassen und systembezogen vergleichen zu können, wurde im Rahmen dieser Studie ein Reifegradmodell entwickelt. Dieses bildet die Ausgangsbasis zur Ermittlung der KI-Reife in ERP-Systemen und grenzt dabei die folgenden vier KI- bzw. systembezogenen Ebenen voneinander ab: 1) Technische Möglichkeiten, 2) Datenreife, 3) Funktionsreife und 4) Erklärfähigkeit des Systems.
Climate change entails an intensification of extreme weather events that can potentially trigger socioeconomic and energy system disruptions. As we approach 1 degrees C of global warming we should start learning from historical extremes and explicitly incorporate such events in integrated climate-economy and energy systems models.
So richtig schlüssig finden die Medienrechtler Marcus Schladebach und Hans-Christian Gräfe den Vorschlag der EU-Kommission für den Europäischen Media Freedom Act nicht. Unter einer überpathetischen Überschrift regelt er fiktive Fragen, die eigentlich keiner Regelung bedürfen. Zudem ohne Kompetenz auf dem Gebiet der Medienpolitik.
The sky is not the limit
(2022)
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Der Potsdam Grievance Statistics File (PGSF) ist eine historische Datensammlung von Beschwerden, sog. Eingaben, die in der DDR von deren Bürgern eingereicht wurden. Die Eingaben wurden schriftlich oder mündlich gestellt und waren an staatliche Institutionen gerichtet. Der Staat zählte diese Eingaben und kategorisierte sie in Eingabenstatistiken.
Der PGSF enthält Eingabenstatistiken des Zeitraums 1970–1989 einer Wahrscheinlichkeitsstichprobe von im Jahr 1990 existierenden Kreisen. Zusätzlich finden sich Eingabenstatistiken eines Convenience-Samples von Kreisen aus dem Zeitraum 1970–1989.
Leben in der ehemaligen DDR
(2020)
Leben in der ehemaligen DDR
(2019)
Harmonized data file as the basis for comparative analysis of quality of life in the Candidate Countries and the European Union member states, based on seven different data sets, one Eurobarometer survey covering 13 Candidate Countries with an identical set of variables conducted in April 2002, the other six Standard Eurobarometer of different subjects and fielded in different years, each with another set of questions identical with the CC Eurobarometer. Selected aggregate indicators of quality of life ... describing the social situation in the EU15 and Candidate Countries.
The US perennially has a far higher poverty rate than peer-rich democracies.1 This high poverty rate in the US presents an enormous challenge to population health given that considerable research demonstrates that being in poverty is bad for one’s health.2 Despite valuable contributions of prior research on income and mortality, the quantity of mortality associated with poverty in the US remains uknown. In this cohort study, we estimated the association between poverty and mortality and quantified the proportion and number of deaths associated with poverty.
Several overlapping crises which affected the EU during the past ten years have recently aggravated. Especially the progressing refugee crisis, the persisting financial crisis and geopolitical turmoil in the EU's neighbourhood contributed to the rise of anti-EU movements and diverse articulations of Euroscepticism. Although public opinion and mainstream political analysis have easily identified right-wing populism as one of the most important drivers, it is still doubtful if it can be equated with Euroscepticism without further ado. To date it is by no means clear how and where Euroscepticism exactly originates.
Schulgesetz Rheinland-Pfalz
(2000)
À partir des travaux des ethnologues qui ont décrit le fonctionnement des sociétés paysannes de l’Ancien Régime, nous montrons dans cet article comment le récit de l’enfance bretonne de Chateaubriand dans les ‚Mémoires d’outre-tombe‘ obéit à une logique initiatique qui donne à l’animal un rôle de premier plan. Transformée en véritable „aventure“, la capture des oiseaux devient pour l’enfant l’occasion de forger son caractère et de découvrir le sens de l’honneur, tandis que la contemplation de leur envol éveille en lui le goût des voyages qu’il n’a pas encore la possibilité d’assouvir. À Combourg, chouettes et chat noir peuplent les nuits de l’enfant et l’obligent à dompter ses peurs. Quant au cheval, que Chateaubriand a mal appris à maîtriser, il devient sous sa plume l’emblème d’une époque révolue dominée par les privilèges de l’aristocratie et le signe de l’inadaptation des derniers rois de France. Il restera à l’écrivain à s’emparer de cette familiarité avec le monde animal pour nourrir son imaginaire et sa sensibilité de plus en plus grande au sort que lui réserve la société.
PURPOSE: To determine the feasibility of upright compared to supine MRI measurements to determine characteristics of the lumbar spine in AA with spondylolisthesis.
METHODS: Ten AA (n=10; m/f: 4/6; 14.5±1.7y; 163±7cm; 52±8kg) from various sports, diagnosed with spondylolisthesis grade I-II Meyerding confirmed by x-ray in standing lateral view, were included. Open low-field MRI images (0.25 Tesla) in upright (82°) and supine (0°) position were evaluated by two observers. Medical imaging software was used to measure the anterior translation (AT, mm), lumbosacral joint angle (LSJA, °) and lordosis angle (LA, °). Reliability was analyzed by the intra-rater correlation coefficient (ICC) and standard error of measurements (SEM).
RESULTS: Due to motion artifacts during upright position, measures of three participants had to be excluded. Between observers, AT ranged from 4.2±2.7mm to 5.5±1.9mm (ICC=0.94, SEM=0.6mm) in upright and from 4.9±2.4mm to 5.9±3.0mm (ICC=0.89, SEM=0.9mm) in supine position. LSJA varied from 5.1±2.2° to 7.3±1.5° (ICC=0.54, SEM=1.5°) in upright and from 9.8±2.5° to 10±2.4° (ICC=0.73, SEM=1.1°) in supine position. LA differed from 58.8±14.6° to 61.9±6° (ICC=0.94, SEM=1.19°) in upright and from 51.9±11.7° to 52.6±11.1° (ICC=0.98, SEM=1.59°) in supine position.
CONCLUSIONS: Determination of AT and LA showed good to excellent reliability in both, upright and supine position. In contrast, reliability of LSJA had only moderate to good correlation
between observers and should therefore be interpreted with caution. However, motion artifacts should be taken into consideration during upright imaging procedures.
Acute ankle sprain leads in 40% of all cases to chronic ankle instability (CAI). CAI is related to a variety of motor adaptations at the lower extremities. Previous investigations identified increased muscle activities while landing in CAI compared to healthy control participants. However, it remains unclear whether muscular alterations at the knee muscles are limited to the involved (unstable) ankle or are also present at the uninvolved leg. The latter might potentially indicate a risk of ankle sprain or future injury on the uninvolved leg. Purpose: To assess if there is a difference of knee muscle activities between the involved and uninvolved leg in participants with CAI during perturbed walking. Method: 10 participants (6 females; 4 males; 26±4 years; 169±9 cm; 65±7 kg) with unilateral CAI walked on a split-belt treadmill (1m/s) for 5 minutes of baseline walking and 6 minutes of perturbed walking (left and right side, each 10 perturbations). Electromyography (EMG) measurements were performed at biceps femoris (BF) and rectus femoris (RF). EMG amplitude (RMS; normalized to MVIC) were analyzed for 200ms pre-heel contact (Pre200), 100ms post heel contact (Post100) and 200ms after perturbation (Pert200). Data was analyzed by paired t-test/Wilcoxon test based on presence or absence of normal distribution (Bonferroni adjusted α level p≤ 0.0125). Results: No statistical difference was found between involved and uninvolved leg for RF (Pre200: 4±2% and 11± 22%, respectively, p= 0.878; Post100: 10± 5 and 18±31%, p=0.959; Pert200: 6±3% and 13±24%, p=0.721) as well as for BF (Pre200: 12±7% and 11±6, p=0.576; Post100: 10±7% and 9±7%, p=0.732; Pert200: 7±4 and 7±7%, p=0.386). Discussion: No side differences in muscle activity could be revealed for assessed feedforward and feedback responses (perturbed and unperturbed) in unilateral CAI. Reduced inter-individual variability of muscular activities at the involved leg might indicate a rather stereotypical response pattern. It remains to be investigated, whether muscular control at the knee is not affected by CAI, or whether both sides adapted in a similar style to the chronic condition at the ankle.
Chronic ankle instability (CAI) is not only an ankle issue, but also affects sensorimotor system. People with CAI show altered muscle activation in proximal joints such as hip and knee. However, evidence is limited as controversial results have been presented regarding changes in activation of hip muscles in CAI population. PURPOSE: To investigate the effect of CAI on activity of hip muscles during normal walking and walking with perturbations. METHODS: 8 subjects with CAI (23 ± 2 years, 171 ± 7 cm and 65 ± 4 kg) and 8 controls (CON) matched by age, height, weight and dominant leg (25 ± 3 years, 172 ± 7 cm and 65 ± 6 kg) walked shoed on a split-belt treadmill (1 m/s). Subjects performed 5 minutes of baseline walking and 6 minutes walking with 10 perturbations (at 200 ms after heel contact with 42 m/s2 deceleration impulse) on each side. Electromyography signals from gluteus medius (Gmed) and gluteus maximus (Gmax) were recorded while walking. Muscle amplitudes (Root Mean Square normalized to maximum voluntary isometric contraction) were calculated at 200 ms before heel contact (Pre200), 100 ms after heel contact (Post100) during normal walking and 200 ms after perturbations (Pert200). Differences between groups were examined using Mann Whitney U test and Bonferroni correction to account for multiple testing (adjust α level p≤ 0.0125). RESULT: In Gmed, CAI group showed lower muscle amplitude than CON group after heel contact (Post100: 18±7 % and 47±21 %, p< .01) and after walking perturbations ( 31±13 % and 62±26 %, p< .01), but not before heel contact (Pre200: 5±2 % and 11±10 %, p= 0.195). In Gmax, no difference was found between CAI and CON groups in all three time points (Pre200: 12±5 % and 17±12 %, p= 0.574; Post100: 41±21 % and 41±13 %, p= 1.00; Pert200: 79±46 % and 62±35 %, p= 0.505). CONCLUSION: People with CAI activated Gmed less than healthy control in feedback mechanism (after heel contact and walking with perturbations), but not in feedforward mechanism (before heel contact). Less activation on Gmed may affect the balance in frontal plane and increase the risk of recurrent ankle sprain, giving way or feeling ankle instability in patients with CAI during walking. Future studies should investigate the effect of Gmed strengthening or neuromuscular training on CAI rehabilitation.