Refine
Has Fulltext
- no (2)
Year of publication
- 2012 (2) (remove)
Document Type
- Article (2)
Language
- English (2)
Is part of the Bibliography
- yes (2)
Institute
Recently observed large-scale disintegration of Antarctic ice shelves has moved their fronts closer towards grounded ice. In response, ice-sheet discharge into the ocean has accelerated, contributing to global sea-level rise and emphasizing the importance of calving-front dynamics. The position of the ice front strongly influences the stress field within the entire sheet-shelf-system and thereby the mass flow across the grounding line. While theories for an advance of the ice-front are readily available, no general rule exists for its retreat, making it difficult to incorporate the retreat in predictive models. Here we extract the first-order large-scale kinematic contribution to calving which is consistent with large-scale observation. We emphasize that the proposed equation does not constitute a comprehensive calving law but represents the first-order kinematic contribution which can and should be complemented by higher order contributions as well as the influence of potentially heterogeneous material properties of the ice. When applied as a calving law, the equation naturally incorporates the stabilizing effect of pinning points and inhibits ice shelf growth outside of embayments. It depends only on local ice properties which are, however, determined by the full topography of the ice shelf. In numerical simulations the parameterization reproduces multiple stable fronts as observed for the Larsen A and B Ice Shelves including abrupt transitions between them which may be caused by localized ice weaknesses. We also find multiple stable states of the Ross Ice Shelf at the gateway of the West Antarctic Ice Sheet with back stresses onto the sheet reduced by up to 90 % compared to the present state.
Background: Different immunotherapy approaches for the treatment of cancer and autoimmune diseases are being developed and tested in clinical studies worldwide. Their resulting complex experimental data should be properly evaluated, therefore reliable normal healthy control baseline values are indispensable.
Methodology/Principal Findings: To assess intra- and inter-individual variability of various biomarkers, peripheral blood of 16 age and gender equilibrated healthy volunteers was sampled on 3 different days within a period of one month. Complex "crossomics'' analyses of plasma metabolite profiles, antibody concentrations and lymphocyte subset counts as well as whole genome expression profiling in CD4(+)T and NK cells were performed. Some of the observed age, gender and BMI dependences are in agreement with the existing knowledge, like negative correlation between sex hormone levels and age or BMI related increase in lipids and soluble sugars. Thus we can assume that the distribution of all 39.743 analysed markers is well representing the normal Caucasoid population. All lymphocyte subsets, 20% of metabolites and less than 10% of genes, were identified as highly variable in our dataset.
Conclusions/Significance: Our study shows that the intra- individual variability was at least two-fold lower compared to the inter-individual one at all investigated levels, showing the importance of personalised medicine approach from yet another perspective.