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"At-risk" concept
(2005)
"Make a Run for the Border": Chicano Performance Art and the Search for a Space of/for Difference
(2005)
The five Potsdam "Studientage zum Englischen Mittelalter (SEM)" (1999-2003) served a number of purposes. These are fully discussed in this article. The first and foremost idea was to provide a yearly forum for young scholars in English medieval studies to present their research to other scholars in the field and to test their market value ("Nachwuchsfoerderung"). After Potsdam, the SEM meetings are circulating between those universities in the German speaking countries, which feature a Medieval Studies Programme in their departments of English and American Studies. This programme serves to boost their academic profile and etablish centres of excellency for English medieval Studies on the Continent. Networking is another prime objective of the SEMs. See http://www.uni-potsdam.de/u/sem/sem.htm etc.
7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoloata
(2005)
From the acetone extract of the roots of Derris trifoliata an isollavonoid derivative, named 7a-O- methyldeguelol, a modified rotenoid with an open ring-C, representing a new sub-class of isollavonoids (the sub-class is here named as rotenoloid), was isolated and characterised. In addition, the known rotenoids, rotenone, deguelin and alpha-toxicarol, were identified. The structures were determined on the basis of spectroscopic evidence. Rotenone and deguelin were identified as the larvicidal principles of the acetone extract of the roots of Derris trifoliata. (c) 2005 Elsevier Ltd. All rights reserved
The uptake of resources from the environment is a vital process for all organisms. Many experimental studies have revealed that the rate at which this process occurs depends critically on the resource concentration, a relationship called "functional response." However, whether the concentration of the consumer normally affects the functional response has been the subject of a long-standing, predominantly theoretical, debate in ecology. Here we present an experimental test between the alternative hypotheses that food uptake depends either only on the resource concentration or on both the resource and the consumer concentrations. In short-term laboratory experiments, we measured the uptake of radioactively labeled, unicellular green algae (Monoraphidium minutum, resource) by the rotifer Brachionus calyciflorus (a consumer) for varying combinations of resource and consumer concentrations. We found that the food uptake by Brachionus depended on the algal concentration with the relationship best described by a Holling type 3 functional response. We detected significant consumer effects on the functional response only at an extraordinarily high Brachionus density (similar to 125 rotifers/mL), which by far exceeds concentrations normally encountered in the field. We conclude that con sumer-dependent food uptake by planktonic rotifers is a phenomenon that can occur under extreme conditions, but probably plays a minor role in natural environments
Background Soy protein is effective in lowering plasma cholesterol, LDL cholesterol and triglyceride concentrations. It has not been conclusively answered, whether and to what extent other soy constituents may also contribute to this effect. Objective To investigate the change in blood lipid levels after application of two soy-based supplements containing soy protein either without (SuproSoy(R)) or with (Abacor(R)) soy fiber and phospholipids in a randomized placebo-controlled triple-armed study. Methods 121 hypercholesterolemic adults ( 66 females, 55 males) were recruited and randomly assigned to one of three treatments. Over 8 weeks they received daily either 25 g soy protein ( as a component of the supplements Abacor(R) or SuproSoy(R)) or 25 g milk protein ( as a component of placebo). Serum lipids were measured at baseline and after 4, 6 and 8 weeks. Results After 8 weeks of supplementation total cholesterol levels were reduced by 8.0 +/- 9.6% (Abacor(R)) and 3.4 +/- 8.3% (SuproSoy(R)); LDL cholesterol levels by 9.7 +/- 11.7% ( Abacor(R)) and 5.4 +/- 11.6% ( SuproSoy(R)); and Apolipoprotein B levels by 6.9 +/- 14.6% (Abacor(R)) and 4.0 +/- 12.4 % (SuproSoy(R)). Serum levels of HDL cholesterol and triglycerides remained unchanged. Conclusions A preparation combining isolated soy protein with soy fibers and phospholipids showed twice the lipid-lowering effect of a preparation containing isolated soy protein alone. Therefore, such soy-based supplements can be useful in reducing the cardiovascular risk
An unconventional but easily accessible precursor route involving the thermal treatment of hybrid precursors containing an ampholytic polymer matrix is developed to prepare multimetallic oxides of catalytic interest such as transition metal molybdates. A copolymer of diallyldimethylammonium chloride and a functionalized maleamic acid bearing an amine group suited for cation complexation was designed, synthesized and used as a matrix to stabilize inorganic species generated in solution from Ni(NO3)(2)center dot 6H(2)O, Co(NO3)(2)center dot 6H(2)O and/or Mn(NO3)(2)center dot 4H(2)O together with (NH4)(6)Mo(7)O(24)center dot 4H(2)O. UV-vis-NIR as well as C-13-NMR studies suggest that the interactions between the cations and the polymer in solution are mainly electrostatic. Only minor complexation interactions take place under certain conditions. Homogeneous hybrid blends were prepared from these solutions. The presence of a complexing amine group in addition to the charged betaine moieties in the polymer permits stabilization of more than stoichiometric amounts of the metal species in the blends. XRD measurements suggest that the homogeneity in the solid state can be kept up to about 1.5 mol of each metal that is incorporated ( anionic as well as cationic) per mol of repeat units of the copolymer. The blends were calcined under air at 600 degrees C to produce the simple as well as mixed nickel, cobalt and manganese molybdates. Characterization of the final phases by XRD and Raman spectroscopy indicates that the alpha- as well as the beta-molybdate phases can be prepared, and that the mixed structures are solid solutions of the simple NiMoO4, MnMoO4 and CoMoO4. If the precursors engaged are homogeneous, the pH of the precursor solution, the amount of metal that is incorporated in the matrix, and the nature of the polymer matrix seem to exert only a minor influence on the nature of the final phase, which demonstrates the versatility and facile applicability of the method
Parallel File Systems like PVFS2 are a necessary compo nent for high-performance computing. The design of ef ;cient communication layers for these systems is still of great research interest. This paper presents a low- latency messaging method for PVFS2 dedicated for Gigabit Ether net networks and discusses relevant design issues. In con trast to other approaches, we argue that zero-copying can be achieved also for big messages without use of a rendez vous protocol. Further, ef;ciency within the communica tion layer like a small call stack plays an important role.
1 Secondary seed dispersal by wind, the wind-driven movement of seeds along the ground surface, is an important dispersal mechanism for plant species in a range of environments. 2 We formulate a mechanistic model that describes how secondary dispersal by wind is affected by seed traits, wind conditions and obstacles to seed movement. The model simulates the movement paths of individual seeds and can be fully specified using independently measured parameters. 3 We develop an explicit version of the model that uses a spatially explicit representation of obstacle patterns, and also an aggregated version that uses probability distributions to model seed retention at obstacles and seed movement between obstacles. The aggregated version is computationally efficient and therefore suited to large-scale simulations. It provides a very good approximation of the explicit version (R-2 > 0.99) if initial seed positions vary randomly relative to the obstacle pattern. 4 To validate the model, we conducted a field experiment in which we released seeds of seven South African Proteaceae species that differ in seed size and morphology into an arena in which we systematically varied obstacle patterns. When parameterized with maximum likelihood estimates obtained from independent measurements, the explicit model version explained 70-77% of the observed variation in the proportion of seeds dispersed over 25 m and 67- 69% of the observed variation in the direction of seed dispersal. 5 The model tended to underestimate dispersal rates, possibly due to the omission of turbulence from the model, although this could also be explained by imprecise estimation of one model parameter (the aerodynamic roughness length). 6 Our analysis of the aggregated model predicts a unimodal relationship between the distance of secondary dispersal by wind and seed size. The model can also be used to identify species with the potential for long-distance seed transport by secondary wind dispersal. 7 The validated model expands the domain of mechanistic dispersal models, contributes to a functional understanding of seed dispersal, and provides a tool for predicting the distances that seeds move
An improved method for spectral subband decomposition based on simultaneous fitting of the initial spectrum and a set of its derivatives is introduced. Additionally, it procedure for finding an optimal smoothing filter to obtain undistorted derivatives IS Suggested. The proposed method is demonstrated with a model spectrum as well its with experimental absorption spectra of the photosynthetic antenna complexes, peridinin-chlorophyll a-protein (PCP) and the main light-harvesting complex of higher plants (LHC II). (c) 2005 Elsevier B.V. All rights reserved
We analyse a generic bottom-up nutrient phytoplankton model to help understand the dynamics of seasonally recurring algae blooms. The deterministic model displays a wide spectrum of dynamical behaviours, from simple cyclical blooms which trigger annually, to irregular chaotic blooms in which both the time between outbreaks and their magnitudes are erratic. Unusually, despite the persistent seasonal forcing, it is extremely difficult to generate blooms that are both annually recurring and also chaotic or irregular (i.e. in amplitude) even though this characterizes many real time series. Instead the model has a tendency to `skip' with outbreaks often being suppressed from one year to the next. This behaviour is studied in detail and we develop an analytical expression to describe the model's flow in phase space, yielding insights into the mechanism of the bloom recurrence. We also discuss how modifications to the equations through the inclusion of appropriate functional forms can generate more realistic dynamics.
Myofibrillar myopathy (MFM) is a human disease that is characterized by focal myofibrillar destruction and pathological cytoplasmic protein aggregations. In an extended German pedigree with a novel form of MFM characterized by clinical features of a limb-girdle myopathy and morphological features of MFM, we identified a cosegregating, heterozygous nonsense mutation (8130G -> A; W2710X) in the filamin c gene ( FLNC) on chromosome 7q32.1. The mutation is the first found in FLNC and is localized in the dimerization domain of filamin c. Functional studies showed that, in the truncated mutant protein, this domain has a disturbed secondary structure that leads to the inability to dimerize properly. As a consequence of this malfunction, the muscle fibers of our patients display massive cytoplasmic aggregates containing filamin c and several Z-disk-associated and sarcolemmal proteins
A new condensation principle
(2005)
We generalize del(A), which was introduced in [Schinfinity], to larger cardinals. For a regular cardinal kappa>N-0 we denote by del(kappa)(A) the statement that Asubset of or equal tokappa and for all regular theta>kappa(o), {X is an element of[L-theta[A]](<) : X &AND; &ISIN; &AND; otp (X &AND; Ord) &ISIN; Card (L[A&AND;X&AND;])} is stationary in [L-[A]](<). It was shown in [Sch&INFIN;] that &DEL;(N1) (A) can hold in a set-generic extension of L. We here prove that &DEL;(N2) (A) can hold in a set-generic extension of L as well. In both cases we in fact get equiconsistency theorems. This strengthens results of [Ra00] and [Ran01]. &DEL;(N3) () is equivalent with the existence of 0#
In C-13 NMR spectroscopy, there are many empirical methods for fast and exact computation of C-13 chemical shifts; comparable procedures for Si-29 NMR chemical shifts are not existing or are older than 20 years. On basis of the largest database of Si-29 chemical shifts available, along this paper a relatively simple procedure for the similarly exact calculation of the Si-29 chemical shifts of disilanes (average margin of error ca. 3.7 ppm) is given. (c) 2005 Elsevier B.V. All rights reserved
A package of programs written using the symbolic mathematics program, Mathematicatrademark, has been developed. Its principal usage is in teaching the LIMM method to students and demonstrating data analysis by means of the Polynomial Regularization Method (PRM). A large number of variables can be changed in the program and their effects can be shown graphically. Students at the University of Potsdam and Monash University have used the program successfully
Early Ilerdian (Early Eocene, Shallow Benthic Zones 5 and 6) carbonate systems of the Pyrenees shelf were deposited after a time of severe climatic ('Paleocene-Eocene Thermal Maximum, PETM') and phylogenetic ('Larger Foraminifer Turnover') changes. They reflect the radiation of nummulitid, alveolinid, and orbitolitid larger foraminifera after remarkable biotic changes at the end of the Paleocene, and announce their subsequent flourishing in the Middle Eocene. A paleoenvironmental model for tropical carbonate environments of this particular time interval is provided herein. During the Early Ilerdian, the inner and middle ramp deposits from Minerve, Campo and Serraduy revealed the end-member of a tropical carbonate factory with carbonate production dominated by the end-members of biotically (photo-autotrophic skeletal) controlled and biotically induced carbonate precipitation. Inner platform environments are dominated by alveolinids and in part by orbitolitids, middle platform environments are dominated by nummulitids. Corals are present, but they do not form reefs, which is a typical feature for the Eocene. Nummulite shoal complexes, which are well-known from the Middle Eocene are also absent during the studied Early Ilerdian interval, which may reflect the early evolutionary stage of this group
A Procedural Model for the Production of reusable and standard-compliant E-Learning Offerings
(2005)
Cost-efficient production of high-quality learning contents is an important success factor for a sustainable and economic realisation of E-Learning. This necessitates the design of sustainable production processes, which create reusable Learning Objects and require minimal resources. In such a context, this contribution introduces a practical and business-process oriented Procedural Model for the Production of reusable and standard-compliant E-Learning Offerings. It has been developed and applied in a project that produces learning contents for a Master program of an international virtual university. After the introduction of a reengineering method, a special analysis instrument for E-Learning has been designed to analyse the existing production processes and to improve them in terms of efficiency, costs, standard- compliance, and process automation. The method introduced is hence not focussing on individual technical solutions but on the efficiency of the whole E-Learning production and value chain. It gives an orientation for establishing and maintaining sustainable and competitive E-Learning production processes with appropriate effort.
We report on a receiver function study of the crust and upper mantle within DESERT, a multidisciplinary geophysical project to study the lithosphere across the Dead Sea Transform (DST). A temporary seismic network was operated on both sides of the DST between 2000 April and 2001 June. The depth of the Moho increases smoothly from about 30 to 34-38 km towards the east across the DST, with significant north-south variations east of the DST. These Moho depth estimates from receiver functions are consistent with results from steep-and wide-angle controlled-source techniques. Steep-angle reflections and receiver functions reveal an additional discontinuity in the lower crust, but only east of the DST. This leads to the conclusion that the internal crustal structure east and west of the DST is different. The P to S converted phases from both discontinuities at 410 and 660 km are delayed by 2 s with respect to the IASP91 global reference model. This would indicate that the transition zone is consistent with the global average, but the upper mantle above 410 km is 3-4 per cent slower than the standard earth model
Inositol polyphosphates, such as inositol trisphosphate, are pivotal intracellular signaling molecules in eukaryotic cells. In higher plants the mechanism for the regulation of the type and the level of these signaling molecules is poorly understood. In this study we investigate the physiological function of an Arabidopsis (Arabidopsis thaliana) gene encoding inositol polyphosphate kinase (AtIPK2alpha), which phosphorylates inositol 1,4,5-trisphosphate successively at the D-6 and D-3 positions, and inositol 1,3,4,5-tetrakisphosphate at D-6, resulting in the generation of inositol 1,3,4,5,6-pentakisphosphate. Semiquantitative reverse transcription-PCR and promoter-beta-glucuronidase reporter gene analyses showed that AtIPK2alpha is expressed in various tissues, including roots and root hairs, stem, leaf, pollen grains, pollen tubes, the flower stigma, and siliques. Transgenic Arabidopsis plants expressing the AtIPK2alpha antisense gene under its own promoter were generated. Analysis of several independent transformants exhibiting strong reduction in AtIPK2alpha transcript levels showed that both pollen germination and pollen tube growth were enhanced in the antisense lines compared to wild-type plants, especially in the presence of nonoptimal low Ca2+ concentrations in the culture medium. Furthermore, root growth and root hair development were also stimulated in the antisense lines, in the presence of elevated external Ca2+ concentration or upon the addition of EGTA. In addition, seed germination and early seedling growth was stimulated in the antisense lines. These observations suggest a general and important role of AtIPK2alpha, and hence inositol polyphosphate metabolism, in the regulation of plant growth most likely through the regulation of calcium signaling, consistent with the well-known function of inositol trisphosphate in the mobilization of intracellular calcium stores
Functional groups with diverse responses to environmental factors sum to produce communities with less temporal variability in their biomass than those lacking this diversity. The detection of these compensatory dynamics can be complicated by a spatio-temporal alternation in the environmental factors limiting growth (both abiotic and biotic), which restricts the occurrence of compensatory dynamics to certain periods or locations. Hence, resolving the spatio- temporal scale may uncover important spatial and/or temporal components in community variability. Using long-term data from Lake Constance (Bodensee), we find that a reduction in grazing pressure and relaxed competition for nutrients during winter and spring generates coherent dynamics among edible and less edible phytoplankton. During summer and fall, when both grazing pressure and nutrient limitation are present, edible and less edible phytoplankton exhibit compensatory dynamics. This study supports recent work suggesting that both abiotic and biotic interactions promote compensatory dynamics and to our knowledge, this is the first example of a system where compensatory and coherent dynamics seasonally alternate.
1 Two isoforms of the rat prostaglandin E-2 receptor, rEP3 alpha-R and rEP3 beta-R, differ only in their C- terminal domain. To analyze the function of the rEP3-R C-terminal domain in agonist induced desensitization, a cluster of Ser/Thr residues in the C-terminal domain of the rEP3 alpha-R was mutated to Ala and both isoforms and the receptor mutant (rEP3 alpha-ST341-349A-R) were stably expressed in HEK293 cells. 2 All rEP3-R receptors showed a similar ligand- binding profile. They were functionally coupled to Gi and reduced forskolin-induced cAMP-formation. 3 Repeated exposure of cells expressing the rEP3 alpha-R isoform to PGE(2) reduced the agonist induced inhibition of forskolin-stimulated cAMP-formation by 50% and led to internalization of the receptor to intracellular endocytotic vesicles. By contrast, Gi- response as well as plasma membrane localization of the rEP3 beta-R and the rEP3 alpha-ST341-349A-R were not affected by prior agonist-stimulation. 4 Agonist-stimulation of HEK293-rEP3 alpha-R cells induced a time- and dose-dependent phosphorylation of the receptor most likely by G protein-coupled receptor kinases and not by protein kinase A or protein kinase C. By contrast, upon agonist-stimulation the rEP3 beta-R was not phosphorylated and the rEP3 alpha-ST341-349A-R was phosphorylated only weakly. 5 These results led to the hypothesis that agonist-induced desensitization of the rEP3 alpha-R isoform is mediated most likely by a GRK-dependent phosphorylation of Ser/Thr residues 341 - 349. Phosphorylation then initiates uncoupling of the receptor from Gi protein and receptor internalization
We present a simple scheme for implementing an atomic phase gate using two degrees of freedom for each atom and discuss its realization with cold rubidium atoms on atom chips. We investigate the performance of this collisional phase gate and show that gate operations with high fidelity can be realized in magnetic traps that are currently available on atom chips
As meta-analyses demonstrate feedback effects on performance, our study examined possible mediators. Based on our cognitive-motivational model [Vollmeyer, R., & Rhemberg, F. (1998). Motivationale Einflusse auf Erwerb und Anwendung von Wissen in einem computersimulierten System [Motivational influences on the acquisition and application of knowledge in a simulated system]. Zeitschrift fur Padagogische Psychologie, 12, 11-23] we examined how feedback changed (1) strategies, and (2) motivation during learning, and by doing so improved (3) final performance. Students (N = 211) learned how a dynamic system works and how to reach given goal states for the system. One group received feedback (i.e., knowledge of performance) the other one did not. We expected learners to improve after they received the first feedback. However, we found that learners expecting feedback used better strategies right from the start. Thus, they acquired more knowledge over fewer trials. Although we had also expected effects of feedback on motivation during learning, we could not support this hypothesis. (c) 2005 Elsevier Ltd. All rights reserved
Mitochondrial diseases may be caused by numerous mutations that alter proteins of the respiratory chain and of other metabolic pathways in the mitochondrium. For clinicians this disease group poses a considerable diagnostic challenge due to ambiguous genotype-phenotype relationships. Until now, only 30 % of the mitochondriopathies can be diagnosed at the molecular level. We therefore need a new diagnostic tool that offers a wide view on the mitochondrial proteins. Here, we present a method to generate a high-resolution, large-gel two-dimensional gel electrophoretic (2-DE) map of a purified fraction of mitochondrial proteins from Epstein-Barr virus-immortalized lymphoblastoid cell line (LCL). LCLs can be easily obtained from patients and control subjects in a routine clinical setting. They often express the biochemical phenotype and can be cultured to high cell numbers, sufficient to gain enough purified material for 2- DE. In total we identified 166 mitochondrial proteins. Thirteen proteins were earlier not known to be of mitochondrial origin. Thirty-nine proteins were associated with human diseases ranging from respiratory chain enzyme deficiencies to disorders of P-oxidation and amino acid metabolism. This 2-DE map is intended to be the first step to diagnose mitochondrial diseases at the proteomic level
Among all voltage-gated K+ channels from the model plant Arabidopsis thaliana, the weakly rectifying K+ channel (K-weak channel) AKT2 displays unique gating properties. AKT2 is exceptionally regulated by phosphorylation: when nonphosphorylated AKT2 behaves as an inward-rectifying potassium channel; phosphorylation of AKT2 abolishes inward rectification by shifting its activation threshold far positive (>200 mV) so that it closes only at voltages positive of + 100 mV. In its phosphorylated form, AKT2 is thus locked in the open state in the entire physiological voltage range. To understand the molecular grounds of this unique gating behavior, we generated chimeras between AKT2 and the conventional inward-rectifying channel KAT1. The transfer of the pore from KAT1 to AKT2 altered the permeation properties of the channel. However, the gating properties were unaffected, suggesting that the pore region of AKT2 is not responsible for the unique K-weak gating. Instead, a lysine residue in S4, highly conserved among all K-weak channels but absent from other plant K+ channels, was pinpointed in a site-directed mutagenesis approach. Substitution of the lysine by serine or aspartate abolished the "open-lock" characteristic and converted AKT2 into an inward- rectifying channel. Interestingly, phosphoregulation of the mutant AKT2-K197S appeared to be similar to that of the K-in channel KAT1: as suggested by mimicking the phosphorylated and dephosphorylated states, phosphorylation induced a shift of the activation threshold of AKT2-K197S by about +50 mV. We conclude that the lysine residue K197 sensitizes AKT2 to phosphoregulation. The phosphorylation-induced reduction of the activation energy in AKT2 is similar to 6 kT larger than in the K197S mutant. It is discussed that this hypersensitive response of AKT2 to phosphorylation equips a cell with the versatility to establish a potassium gradient and to make efficient use of it
Equilibria between the Z (tau(1) = 0 degrees) and E (tau(1) = 180 degrees) conformers of p-substituted phenyl acetates 4 and trifluoroacetates 5 (X = OMe, Me, H, Cl, CN, NO2) were studied by ab initio calculations at the HF/6-31G* and MP2/6-31G* levels of theory. The preference for the Z conformer, Delta E(HF), was calculated to be 5.36 kcal mol(-1) and 7.50 kcal mot(-1) for phenyl acetate and phenyl trifluoroacetate (i.e., with X = H), respectively. The increasing electron-withdrawing ability of the phenyl substituent X increases the preference of the Z conformer. An excellent correlation with a negative slope was observed for both series between Delta E of the E-Z equilibrium and the Hammett sigma constant. By using an appropriate isodesmic reaction, it was shown that electron-withdrawing substituents decrease the stability of both conformers, but the effect is higher with the E conformer. Electron-withdrawing phenyl substituents decrease the delocalization of the lone pair of the ether oxygen to the C=O antibonding orbital (n(O) -> pi*(C=O)) in both the E and Z forms and in both series studied; this effect is higher in the E conformer than in the Z conformer. The n(O) -> pi*(C=O) electron donation has a minimum value with tau(1) = 90 degrees and a maximum value with tau(1) = 90 degrees (the Z conformer), the value with tau(1) = 180 degrees (the E conformer) being between these two values, obviously due to steric hindrance. The effects of the phenyl substituents on the reactivity of the esters studied are discussed in terms of molecular orbital interactions. ED/EW substituents adjust the availability of the pi*(C=O) antibonding orbital to interact with the lone pair orbital of the attacking nucleophile and therefore affect the reactivity: EW substituents increase and ED substituents decrease it. Excellent correlations were observed between the rate coefficients of nucleophilic acyl substitutions and pi*(C=O) occupancies of the ester series 4 and
Aber bitte mit Sahne ...
(2005)