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The nutrient exchange between plant and fungus is the key element of the arbuscular mycorrhizal (AM) symbiosis. The fungus improves the plant’s uptake of mineral nutrients, mainly phosphate, and water, while the plant provides the fungus with photosynthetically assimilated carbohydrates. Still, the knowledge about the mechanisms of the nutrient exchange between the symbiotic partners is very limited. Therefore, transport processes of both, the plant and the fungal partner, are investigated in this study. In order to enhance the understanding of the molecular basis underlying this tight interaction between the roots of Medicago truncatula and the AM fungus Rhizophagus irregularis, genes involved in transport processes of both symbiotic partners are analysed here. The AM-specific regulation and cell-specific expression of potential transporter genes of M. truncatula that were found to be specifically regulated in arbuscule-containing cells and in non-arbusculated cells of mycorrhizal roots was confirmed. A model for the carbon allocation in mycorrhizal roots is suggested, in which carbohydrates are mobilized in non-arbusculated cells and symplastically provided to the arbuscule-containing cells. New insights into the mechanisms of the carbohydrate allocation were gained by the analysis of hexose/H+ symporter MtHxt1 which is regulated in distinct cells of mycorrhizal roots. Metabolite profiling of leaves and roots of a knock-out mutant, hxt1, showed that it indeed does have an impact on the carbohydrate balance in the course of the symbiosis throughout the whole plant, and on the interaction with the fungal partner. The primary metabolite profile of M. truncatula was shown to be altered significantly in response to mycorrhizal colonization. Additionally, molecular mechanisms determining the progress of the interaction in the fungal partner of the AM symbiosis were investigated. The R. irregularis transcriptome in planta and in extraradical tissues gave new insight into genes that are differentially expressed in these two fungal tissues. Over 3200 fungal transcripts with a significantly altered expression level in laser capture microdissection-collected arbuscules compared to extraradical tissues were identified. Among them, six previously unknown specifically regulated potential transporter genes were found. These are likely to play a role in the nutrient exchange between plant and fungus. While the substrates of three potential MFS transporters are as yet unknown, two potential sugar transporters are might play a role in the carbohydrate flow towards the fungal partner. In summary, this study provides new insights into transport processes between plant and fungus in the course of the AM symbiosis, analysing M. truncatula on the transcript and metabolite level, and provides a dataset of the R. irregularis transcriptome in planta, providing a high amount of new information for future works.
A detailed description of the characteristics of antimicrobial peptides (AMPs) is highly demanded, since the resistance against traditional antibiotics is an emerging problem in medicine. They are part of the innate immune system in every organism, and they are very efficient in the protection against bacteria, viruses, fungi and even cancer cells. Their advantage is that their target is the cell membrane, in contrast to antibiotics which disturb the metabolism of the respective cell type. This allows AMPs to be more active and faster. The lack of an efficient therapy for some cancer types and the evolvement of resistance against existing antitumor agents make AMPs promising in cancer therapy besides being an alternative to traditional antibiotics. The aim of this work was the physical-chemical characterization of two fragments of LL-37, a human antimicrobial peptide from the cathelicidin family. The fragments LL-32 and LL-20 exhibited contrary behavior in biological experiments concerning their activity against bacterial cells, human cells and human cancer cells. LL-32 had even a higher activity than LL-37, while LL-20 had almost no effect. The interaction of the two fragments with model membranes was systematically studied in this work to understand their mode of action. Planar lipid films were mainly applied as model systems in combination with IR-spectroscopy and X-ray scattering methods. Circular Dichroism spectroscopy in bulk systems completed the results. In the first approach, the structure of the peptides was determined in aqueous solution and compared to the structure of the peptides at the air/water interface. In bulk, both peptides are in an unstructured conformation. Adsorbed and confined to at the air-water interface, the peptides differ drastically in their surface activity as well as in the secondary structure. While LL-32 transforms into an α-helix lying flat at the water surface, LL-20 stays partly unstructured. This is in good agreement with the high antimicrobial activity of LL-32. In the second approach, experiments with lipid monolayers as biomimetic models for the cell membrane were performed. It could be shown that the peptides fluidize condensed monolayers of negatively charged DPPG which can be related to the thinning of a bacterial cell membrane. An interaction of the peptides with zwitterionic PCs, as models for mammalian cells, was not clearly observed, even though LL-32 is haemolytic. In the third approach, the lipid monolayers were more adapted to the composition of human erythrocyte membranes by incorporating sphingomyelin (SM) into the PC monolayers. Physical-chemical properties of the lipid films were determined and the influence of the peptides on them was studied. It could be shown that the interaction of the more active LL-32 is strongly increased for heterogeneous lipid films containing both gel and fluid phases, while the interaction of LL-20 with the monolayers was unaffected. The results indicate an interaction of LL-32 with the membrane in a detergent-like way. Additionally, the modelling of the peptide interaction with cancer cells was performed by incorporating some negatively charged lipids into the PC/SM monolayers, but the increased charge had no effect on the interaction of LL-32. It was concluded, that the high anti-cancer activity of the peptide originates from the changed fluidity of cell membrane rather than from the increased surface charge. Furthermore, similarities to the physical-chemical properties of melittin, an AMP from the bee venom, were demonstrated.
Diet is a major force influencing the intestinal microbiota. This is obvious from drastic changes in microbiota composition after a dietary alteration. Due to the complexity of the commensal microbiota and the high inter-individual variability, little is known about the bacterial response at the cellular level. The objective of this work was to identify mechanisms that enable gut bacteria to adapt to dietary factors. For this purpose, germ-free mice monoassociated with the commensal Escherichia coli K-12 strain MG1655 were fed three different diets over three weeks: a diet rich in starch, a diet rich in non-digestible lactose and a diet rich in casein. Two dimensional gel electrophoresis and electrospray tandem mass spectrometry were applied to identify differentially expressed proteins of E. coli recovered from small intestine and caecum of mice fed the lactose or casein diets in comparison with those of mice fed the starch diet. Selected differentially expressed bacterial proteins were characterised in vitro for their possible roles in bacterial adaptation to the various diets. Proteins belonging to the oxidative stress regulon oxyR such as alkyl hydroperoxide reductase subunit F (AhpF), DNA protection during starvation protein (Dps) and ferric uptake regulatory protein (Fur), which are required for E. coli’s oxidative stress response, were upregulated in E. coli of mice fed the lactose-rich diet. Reporter gene analysis revealed that not only oxidative stress but also carbohydrate-induced osmotic stress led to the OxyR-dependent expression of ahpCF and dps. Moreover, the growth of E. coli mutants lacking the ahpCF or oxyR genes was impaired in the presence of non-digestible sucrose. This indicates that some OxyR-dependent proteins are crucial for the adaptation of E. coli to osmotic stress conditions. In addition, the function of two so far poorly characterised E. coli proteins was analysed: 2 deoxy-D gluconate 3 dehydrogenase (KduD) was upregulated in intestinal E. coli of mice fed the lactose-rich diet and this enzyme and 5 keto 4 deoxyuronate isomerase (KduI) were downregulated on the casein-rich diet. Reporter gene analysis identified galacturonate and glucuronate as inducers of the kduD and kduI gene expression. Moreover, KduI was shown to facilitate the breakdown of these hexuronates, which are normally degraded by uronate isomerase (UxaC), altronate oxidoreductase (UxaB), altronate dehydratase (UxaA), mannonate oxidoreductase (UxuB) and mannonate dehydratase (UxuA), whose expression was repressed by osmotic stress. The growth of kduID-deficient E. coli on galacturonate or glucuronate was impaired in the presence of osmotic stress, suggesting KduI and KduD to compensate for the function of the regular hexuronate degrading enzymes under such conditions. This indicates a novel function of KduI and KduD in E. coli’s hexuronate metabolism. Promotion of the intracellular formation of hexuronates by lactose connects these in vitro observations with the induction of KduD on the lactose-rich diet. Taken together, this study demonstrates the crucial influence of osmotic stress on the gene expression of E. coli enzymes involved in stress response and metabolic processes. Therefore, the adaptation to diet-induced osmotic stress is a possible key factor for bacterial colonisation of the intestinal environment.
Die Dissertation beschreibt die Herstellung von ringförmigen Verbindungen (Naphthalenophanen) mit Hilfe der Dehydro-Diels-Alder-Reaktion, wobei immer Enantiomerenpaare auftreten. Es wird der diastereoselektive Aufbau von Naphthalenophanen und der enantiomeren reine Aufbau von Biarylen untersucht. Desweiteren werden die physikalischen Eigenschaften der erhaltenen Verbindungen, wie die Phosphoreszenz, Trennbarkeit der entstehenden Enantiomere und die Ringspannung beschrieben.
Information flows in EU policy-making are heavily dependent on personal networks, both within the Brussels sphere but also reaching outside the narrow limits of the Belgian capital. These networks develop for example in the course of formal and informal meetings or at the sidelines of such meetings. A plethora of committees at European, transnational and regional level provides the basis for the establishment of pan-European networks. By studying affiliation to those committees, basic network structures can be uncovered. These affiliation network structures can then be used to predict EU information flows, assuming that certain positions within the network are advantageous for tapping into streams of information while others are too remote and peripheral to provide access to information early enough. This study has tested those assumptions for the case of the reform of the Common Fisheries Policy for the time after 2012. Through the analysis of an affiliation network based on participation in 10 different fisheries policy committees over two years (2009 and 2010), network data for an EU-wide network of about 1300 fisheries interest group representatives and more than 200 events was collected. The structure of this network showed a number of interesting patterns, such as – not surprisingly – a rather central role of Brussels-based committees but also close relations of very specific interests to the Brussels-cluster and stronger relations between geographically closer maritime regions. The analysis of information flows then focused on access to draft EU Commission documents containing the upcoming proposal for a new basic regulation of the Common Fisheries Policy. It was first documented that it would have been impossible to officially obtain this document and that personal networks were thus the most likely sources for fisheries policy actors to obtain access to these “leaks” in early 2011. A survey of a sample of 65 actors from the initial network supported these findings: Only a very small group had accessed the draft directly from the Commission. Most respondents who obtained access to the draft had received it from other actors, highlighting the networked flow of informal information in EU politics. Furthermore, the testing of the hypotheses connecting network positions and the level of informedness indicated that presence in or connections to the Brussels sphere had both advantages for overall access to the draft document and with regard to timing. Methodologically, challenges of both the network analysis and the analysis of information flows but also their relevance for the study of EU politics have been documented. In summary, this study has laid the foundation for a different way to study EU policy-making by connecting topical and methodological elements – such as affiliation network analysis and EU committee governance – which so far have not been considered together, thereby contributing in various ways to political science and EU studies.
Gegenstand dieser Arbeit sind sog. nicht-kanonische bzw. unintegrierte Nebensätze. Diese Nebensätze zeichnen sich dadurch aus, dass sie sich mittels gängiger Kriterien (Satzgliedstatus, Verbletztstellung) nicht klar als koordiniert oder subordiniert beschreiben lassen. Das Phänomen nicht-kanonischer Nebensätze ist ein Thema, welches in der Sprachwissenschaft generell seit den späten Siebzigern (Davison 1979) diskutiert wird und spätestens mit Fabricius-Hansen (1992) auch innerhalb der germanistischen Linguistik angekommen ist. Ein viel beachteter Komplex ist hierbei – neben der reinen Identifizierung nicht-kanonischer Satzgefüge – meist auch die Erstellung einer Klassifikation zur Erfassung zumindest einiger nicht-kanonischer Gefüge, wie dies etwa bei Fabricius-Hansen (1992) und Reis (1997) zu sehen ist. Das Ziel dieser Studie ist es, eine exhaustive Klassifikation der angesprochenen Nebensatztypen vorzunehmen. Dazu werden zunächst – unter Zuhilfenahme von Korpusdaten – alle potentiellen Subordinationsmerkmale genauer untersucht, da die meisten bisherigen Studien zu diesem Thema die stets gleichen Merkmale als gegeben voraussetzen. Dabei wird sich herausstellen, dass nur eine kleine Anzahl von Merkmalen sich wirklich zweifelsfrei dazu eignet, Aufschluss über die Satzverknüpfungsqualität zu geben. Die anschließend aufgestellte Taxonomie deutscher Nebensätze wird schließlich einzig mit der Postulierung einer nicht-kanonischen Nebensatzklasse auskommen. Sie ist darüber hinaus auch in der Lage, die zahlreich vorkommenden Ausnahmefälle zu erfassen. Dies heißt konkret, dass auch etwaige Nebensätze, die sich aufgrund bestimmter Eigenschaften teilweise idiosynkratisch verhalten, einfach in die vorgeschlagene Klassifikation übernommen werden können. In diesem Zuge werde ich weiterhin zeigen, wie eine Nebensatzklassifikation auch sog. sekundären Subordinationsmerkmalen gerecht werden kann, obwohl diese sich hinsichtlich der einzelnen Nebensatzklassen nicht einheitlich verhalten. Schließlich werde ich eine theoretische Modellierung der zuvor postulierten Taxonomie vornehmen, die auf Basis der HPSG mittels Merkmalsvererbung alle möglichen Nebensatztypen zu erfassen imstande ist.
Logging and large earthquakes are disturbances that may significantly affect hydrological and erosional processes and process rates, although in decisively different ways. Despite numerous studies that have documented the impacts of both deforestation and earthquakes on water and sediment fluxes, a number of details regarding the timing and type of de- and reforestation; seismic impacts on subsurface water fluxes; or the overall geomorphic work involved have remained unresolved. The main objective of this thesis is to address these shortcomings and to better understand and compare the hydrological and erosional process responses to such natural and man-made disturbances. To this end, south-central Chile provides an excellent natural laboratory owing to its high seismicity and the ongoing conversion of land into highly productive plantation forests. In this dissertation I combine paired catchment experiments, data analysis techniques, and physics-based modelling to investigate: 1) the effect of plantation forests on water resources, 2) the source and sink behavior of timber harvest areas in terms of overland flow generation and sediment fluxes, 3) geomorphic work and its efficiency as a function of seasonal logging, 4) possible hydrologic responses of the saturated zone to the 2010 Maule earthquake and 5) responses of the vadose zone to this earthquake. Re 1) In order to quantify the hydrologic impact of plantation forests, it is fundamental to first establish their water balances. I show that tree species is not significant in this regard, i.e. Pinus radiata and Eucalyptus globulus do not trigger any decisive different hydrologic response. Instead, water consumption is more sensitive to soil-water supply for the local hydro-climatic conditions. Re 2) Contradictory opinions exist about whether timber harvest areas (THA) generate or capture overland flow and sediment. Although THAs contribute significantly to hydrology and sediment transport because of their spatial extent, little is known about the hydrological and erosional processes occurring on them. I show that THAs may act as both sources and sinks for overland flow, which in turn intensifies surface erosion. Above a rainfall intensity of ~20 mm/h, which corresponds to <10% of all rainfall, THAs may generate runoff whereas below that threshold they remain sinks. The overall contribution of Hortonian runoff is thus secondary considering the local rainfall regime. The bulk of both runoff and sediment is generated by Dunne, saturation excess, overland flow. I also show that logging may increase infiltrability on THAs which may cause an initial decrease in streamflow followed by an increase after the groundwater storage has been refilled. Re 3) I present changes in frequency-magnitude distributions following seasonal logging by applying Quantile Regression Forests at hitherto unprecedented detail. It is clearly the season that controls the hydro-geomorphic work efficiency of clear cutting. Logging, particularly dry seasonal logging, caused a shift of work efficiency towards less flashy and mere but more frequent moderate rainfall-runoff events. The sediment transport is dominated by Dunne overland flow which is consistent with physics-based modelling using WASA-SED. Re 4) It is well accepted that earthquakes may affect hydrological processes in the saturated zone. Assuming such flow conditions, consolidation of saturated saprolitic material is one possible response. Consolidation raises the hydraulic gradients which may explain the observed increase in discharge following earthquakes. By doing so, squeezed water saturates the soil which in turn increases the water accessible for plant transpiration. Post-seismic enhanced transpiration is reflected in the intensification of diurnal cycling. Re 5) Assuming unsaturated conditions, I present the first evidence that the vadose zone may also respond to seismic waves by releasing pore water which in turn feeds groundwater reservoirs. By doing so, water tables along the valley bottoms are elevated thus providing additional water resources to the riparian vegetation. By inverse modelling, the transient increase in transpiration is found to be 30-60%. Based on the data available, both hypotheses, are not testable. Finally, when comparing the hydrological and erosional effects of the Maule earthquake with the impact of planting exotic plantation forests, the overall observed earthquake effects are comparably small, and limited to short time scales.
In the presence of a solid-liquid or liquid-air interface, bacteria can choose between a planktonic and a sessile lifestyle. Depending on environmental conditions, cells swimming in close proximity to the interface can irreversibly attach to the surface and grow into three-dimensional aggregates where the majority of cells is sessile and embedded in an extracellular polymer matrix (biofilm). We used microfluidic tools and time lapse microscopy to perform experiments with the polarly flagellated soil bacterium Pseudomonas putida (P. putida), a bacterial species that is able to form biofilms. We analyzed individual trajectories of swimming cells, both in the bulk fluid and in close proximity to a glass-liquid interface. Additionally, surface related growth during the early phase of biofilm formation was investigated. In the bulk fluid, P.putida shows a typical bacterial swimming pattern of alternating periods of persistent displacement along a line (runs) and fast reorientation events (turns) and cells swim with an average speed around 24 micrometer per second. We found that the distribution of turning angles is bimodal with a dominating peak around 180 degrees. In approximately six out of ten turning events, the cell reverses its swimming direction. In addition, our analysis revealed that upon a reversal, the cell systematically changes its swimming speed by a factor of two on average. Based on the experimentally observed values of mean runtime and rotational diffusion, we presented a model to describe the spreading of a population of cells by a run-reverse random walker with alternating speeds. We successfully recover the mean square displacement and, by an extended version of the model, also the negative dip in the directional autocorrelation function as observed in the experiments. The analytical solution of the model demonstrates that alternating speeds enhance a cells ability to explore its environment as compared to a bacterium moving at a constant intermediate speed. As compared to the bulk fluid, for cells swimming near a solid boundary we observed an increase in swimming speed at distances below d= 5 micrometer and an increase in average angular velocity at distances below d= 4 micrometer. While the average speed was maximal with an increase around 15% at a distance of d= 3 micrometer, the angular velocity was highest in closest proximity to the boundary at d=1 micrometer with an increase around 90% as compared to the bulk fluid. To investigate the swimming behavior in a confinement between two solid boundaries, we developed an experimental setup to acquire three-dimensional trajectories using a piezo driven objective mount coupled to a high speed camera. Results on speed and angular velocity were consistent with motility statistics in the presence of a single boundary. Additionally, an analysis of the probability density revealed that a majority of cells accumulated near the upper and lower boundaries of the microchannel. The increase in angular velocity is consistent with previous studies, where bacteria near a solid boundary were shown to swim on circular trajectories, an effect which can be attributed to a wall induced torque. The increase in speed at a distance of several times the size of the cell body, however, cannot be explained by existing theories which either consider the drag increase on cell body and flagellum near a boundary (resistive force theory) or model the swimming microorganism by a multipole expansion to account for the flow field interaction between cell and boundary. An accumulation of swimming bacteria near solid boundaries has been observed in similar experiments. Our results confirm that collisions with the surface play an important role and hydrodynamic interactions alone cannot explain the steady-state accumulation of cells near the channel walls. Furthermore, we monitored the number growth of cells in the microchannel under medium rich conditions. We observed that, after a lag time, initially isolated cells at the surface started to grow by division into colonies of increasing size, while coexisting with a comparable smaller number of swimming cells. After 5:50 hours, we observed a sudden jump in the number of swimming cells, which was accompanied by a breakup of bigger clusters on the surface. After approximately 30 minutes where planktonic cells dominated in the microchannel, individual swimming cells reattached to the surface. We interpret this process as an emigration and recolonization event. A number of complementary experiments were performed to investigate the influence of collective effects or a depletion of the growth medium on the transition. Similar to earlier observations on another bacterium from the same family we found that the release of cells to the swimming phase is most likely the result of an individual adaption process, where syntheses of proteins for flagellar motility are upregulated after a number of division cycles at the surface.
Requirements engineers have to elicit, document, and validate how stakeholders act and interact to achieve their common goals in collaborative scenarios. Only after gathering all information concerning who interacts with whom to do what and why, can a software system be designed and realized which supports the stakeholders to do their work. To capture and structure requirements of different (groups of) stakeholders, scenario-based approaches have been widely used and investigated. Still, the elicitation and validation of requirements covering collaborative scenarios remains complicated, since the required information is highly intertwined, fragmented, and distributed over several stakeholders. Hence, it can only be elicited and validated collaboratively. In times of globally distributed companies, scheduling and conducting workshops with groups of stakeholders is usually not feasible due to budget and time constraints. Talking to individual stakeholders, on the other hand, is feasible but leads to fragmented and incomplete stakeholder scenarios. Going back and forth between different individual stakeholders to resolve this fragmentation and explore uncovered alternatives is an error-prone, time-consuming, and expensive task for the requirements engineers. While formal modeling methods can be employed to automatically check and ensure consistency of stakeholder scenarios, such methods introduce additional overhead since their formal notations have to be explained in each interaction between stakeholders and requirements engineers. Tangible prototypes as they are used in other disciplines such as design, on the other hand, allow designers to feasibly validate and iterate concepts and requirements with stakeholders. This thesis proposes a model-based approach for prototyping formal behavioral specifications of stakeholders who are involved in collaborative scenarios. By simulating and animating such specifications in a remote domain-specific visualization, stakeholders can experience and validate the scenarios captured so far, i.e., how other stakeholders act and react. This interactive scenario simulation is referred to as a model-based virtual prototype. Moreover, through observing how stakeholders interact with a virtual prototype of their collaborative scenarios, formal behavioral specifications can be automatically derived which complete the otherwise fragmented scenarios. This, in turn, enables requirements engineers to elicit and validate collaborative scenarios in individual stakeholder sessions – decoupled, since stakeholders can participate remotely and are not forced to be available for a joint session at the same time. This thesis discusses and evaluates the feasibility, understandability, and modifiability of model-based virtual prototypes. Similarly to how physical prototypes are perceived, the presented approach brings behavioral models closer to being tangible for stakeholders and, moreover, combines the advantages of joint stakeholder sessions and decoupled sessions.
Der Untersuchungsgegenstand der vorliegenden Arbeit ist, die mit dem Begriff „Design Thinking“ verbundenen Diskurse zu bestimmen und deren Themen, Konzepte und Bezüge herauszuarbeiten. Diese Zielstellung ergibt sich aus den mehrfachen Widersprüchen und Vieldeutigkeiten, die die gegenwärtigen Verwendungen des Design-Thinking-Begriffs charakterisieren und den kohärenten Gebrauch in Wissenschaft und Wirtschaft erschweren. Diese Arbeit soll einen Beitrag dazu leisten, „Design Thinking“ in den unterschiedlichen Diskurszusammenhängen grundlegend zu verstehen und für zukünftige Verwendungen des Design-Thinking-Begriffs eine solide Argumentationsbasis zu schaffen.
In this work, thermosensitive hydrogels having tunable thermo-mechanical properties were synthesized. Generally the thermal transition of thermosensitive hydrogels is based on either a lower critical solution temperature (LCST) or critical micelle concentration/ temperature (CMC/ CMT). The temperature dependent transition from sol to gel with large volume change may be seen in the former type of thermosensitive hydrogels and is negligible in CMC/ CMT dependent systems. The change in volume leads to exclusion of water molecules, resulting in shrinking and stiffening of system above the transition temperature. The volume change can be undesired when cells are to be incorporated in the system. The gelation in the latter case is mainly driven by micelle formation above the transition temperature and further colloidal packing of micelles around the gelation temperature. As the gelation mainly depends on concentration of polymer, such a system could undergo fast dissolution upon addition of solvent. Here, it was envisioned to realize a thermosensitive gel based on two components, one responsible for a change in mechanical properties by formation of reversible netpoints upon heating without volume change, and second component conferring degradability on demand. As first component, an ABA triblockcopolymer (here: Poly(ethylene glycol)-b-poly(propylene glycol)-b-poly(ethylene glycol) (PEPE) with thermosensitive properties, whose sol-gel transition on the molecular level is based on micellization and colloidal jamming of the formed micelles was chosen, while for the additional macromolecular component crosslinking the formed micelles biopolymers were employed. The synthesis of the hydrogels was performed in two ways, either by physical mixing of compounds showing electrostatic interactions, or by covalent coupling of the components. Biopolymers (here: the polysaccharides hyaluronic acid, chondroitin sulphate, or pectin, as well as the protein gelatin) were employed as additional macromolecular crosslinker to simultaneously incorporate an enzyme responsiveness into the systems. In order to have strong ionic/electrostatic interactions between PEPE and polysaccharides, PEPE was aminated to yield predominantly mono- or di-substituted PEPEs. The systems based on aminated PEPE physically mixed with HA showed an enhancement in the mechanical properties such as, elastic modulus (G′) and viscous modulus (G′′) and a decrease of the gelation temperature (Tgel) compared to the PEPE at same concentration. Furthermore, by varying the amount of aminated PEPE in the composition, the Tgel of the system could be tailored to 27-36 °C. The physical mixtures of HA with di-amino PEPE (HA·di-PEPE) showed higher elastic moduli G′ and stability towards dissolution compared to the physical mixtures of HA with mono-amino PEPE (HA·mono-PEPE). This indicates a strong influence of electrostatic interaction between –COOH groups of HA and –NH2 groups of PEPE. The physical properties of HA with di-amino PEPE (HA·di-PEPE) compare beneficially with the physical properties of the human vitreous body, the systems are highly transparent, and have a comparable refractive index and viscosity. Therefore,this material was tested for a potential biological application and was shown to be non-cytotoxic in eluate and direct contact tests. The materials will in the future be investigated in further studies as vitreous body substitutes. In addition, enzymatic degradation of these hydrogels was performed using hyaluronidase to specifically degrade the HA. During the degradation of these hydrogels, increase in the Tgel was observed along with decrease in the mechanical properties. The aminated PEPE were further utilised in the covalent coupling to Pectin and chondroitin sulphate by using EDC as a coupling agent. Here, it was possible to adjust the Tgel (28-33 °C) by varying the grafting density of PEPE to the biopolymer. The grafting of PEPE to Pectin enhanced the thermal stability of the hydrogel. The Pec-g-PEPE hydrogels were degradable by enzymes with slight increase in Tgel and decrease in G′ during the degradation time. The covalent coupling of aminated PEPE to HA was performed by DMTMM as a coupling agent. This method of coupling was observed to be more efficient compared to EDC mediated coupling. Moreover, the purification of the final product was performed by ultrafiltration technique, which efficiently removed the unreacted PEPE from the final product, which was not sufficiently achieved by dialysis. Interestingly, the final products of these reaction were in a gel state and showed enhancement in the mechanical properties at very low concentrations (2.5 wt%) near body temperature. In these hydrogels the resulting increase in mechanical properties was due to the combined effect of micelle packing (physical interactions) by PEPE and covalent netpoints between PEPE and HA. PEPE alone or the physical mixtures of the same components were not able to show thermosensitive behavior at concentrations below 16 wt%. These thermosensitive hydrogels also showed on demand solubilisation by enzymatic degradation. The concept of thermosensitivity was introduced to 3D architectured porous hydrogels, by covalently grafting the PEPE to gelatin and crosslinking with LDI as a crosslinker. Here, the grafted PEPE resulted in a decrease in the helix formation in gelatin chains and after fixing the gelatin chains by crosslinking, the system showed an enhancement in the mechanical properties upon heating (34-42 °C) which was reversible upon cooling. A possible explanation of the reversible changes in mechanical properties is the strong physical interactions between micelles formed by PEPE being covalently linked to gelatin. Above the transition temperature, the local properties were evaluated by AFM indentation of pore walls in which an increase in elastic modulus (E) at higher temperature (37 °C) was observed. The water uptake of these thermosensitive architectured porous hydrogels was also influenced by PEPE and temperature (25 °C and 37 °C), showing lower water up take at higher temperature and vice versa. In addition, due to the lower water uptake at high temperature, the rate of hydrolytic degradation of these systems was found to be decreased when compared to pure gelatin architectured porous hydrogels. Such temperature sensitive architectured porous hydrogels could be important for e.g. stem cell culturing, cell differentiation and guided cell migration, etc. Altogether, it was possible to demonstrate that the crosslinking of micelles by a macromolecular crosslinker increased the shear moduli, viscosity, and stability towards dissolution of CMC-based gels. This effect could be likewise be realized by covalent or non-covalent mechanisms such as, micelle interactions, physical interactions of gelatin chains and physical interactions between gelatin chains and micelles. Moreover, the covalent grafting of PEPE will create additional net-points which also influence the mechanical properties of thermosensitive architectured porous hydrogels. Overall, the physical and chemical interactions and reversible physical interactions in such thermosensitive architectured porous hydrogels gave a control over the mechanical properties of such complex system. The hydrogels showing change of mechanical properties without a sol-gel transition or volume change are especially interesting for further study with cell proliferation and differentiation.
Intensive Forschung hat in den vergangenen Jahrzehnten zu einer sehr detaillierten Charakterisierung des Geschmackssystems der Säugetiere geführt. Dennoch sind mit den bislang eingesetzten Methoden wichtige Fragestellungen unbeantwortet geblieben. Eine dieser Fragen gilt der Unterscheidung von Bitterstoffen. Die Zahl der Substanzen, die für den Menschen bitter schmecken und in Tieren angeborenes Aversionsverhalten auslösen, geht in die Tausende. Diese Substanzen sind sowohl von der chemischen Struktur als auch von ihrer Wirkung auf den Organismus sehr verschieden. Während viele Bitterstoffe potente Gifte darstellen, sind andere in den Mengen, die mit der Nahrung aufgenommen werden, harmlos oder haben sogar positive Effekte auf den Körper. Zwischen diesen Gruppen unterscheiden zu können, wäre für ein Tier von Vorteil. Ein solcher Mechanismus ist jedoch bei Säugetieren nicht bekannt. Das Ziel dieser Arbeit war die Untersuchung der Verarbeitung von Geschmacksinformation in der ersten Station der Geschmacksbahn im Mausgehirn, dem Nucleus tractus solitarii (NTS), mit besonderem Augenmerk auf der Frage nach der Diskriminierung verschiedener Bitterstoffe. Zu diesem Zweck wurde eine neue Untersuchungsmethode für das Geschmackssystem etabliert, die die Nachteile bereits verfügbarer Methoden umgeht und ihre Vorteile kombiniert. Die Arc-catFISH-Methode (cellular compartment analysis of temporal activity by fluorescent in situ hybridization), die die Charakterisierung der Antwort großer Neuronengruppen auf zwei Stimuli erlaubt, wurde zur Untersuchung geschmacksverarbeitender Zellen im NTS angewandt. Im Zuge dieses Projekts wurde erstmals eine stimulusinduzierte Arc-Expression im NTS gezeigt. Die ersten Ergebnisse offenbarten, dass die Arc-Expression im NTS spezifisch nach Stimulation mit Bitterstoffen auftritt und sich die Arc exprimierenden Neurone vornehmlich im gustatorischen Teil des NTS befinden. Dies weist darauf hin, dass Arc-Expression ein Marker für bitterverarbeitende gustatorische Neurone im NTS ist. Nach zweimaliger Stimulation mit Bittersubstanzen konnten überlappende, aber verschiedene Populationen von Neuronen beobachtet werden, die unterschiedlich auf die drei verwendeten Bittersubstanzen Cycloheximid, Chininhydrochlorid und Cucurbitacin I reagierten. Diese Neurone sind vermutlich an der Steuerung von Abwehrreflexen beteiligt und könnten so die Grundlage für divergentes Verhalten gegenüber verschiedenen Bitterstoffen bilden.
An important strand of research has investigated the question of how children acquire a morphological system using offline data from spontaneous or elicited child language. Most of these studies have found dissociations in how children apply regular and irregular inflection (Marcus et al. 1992, Weyerts & Clahsen 1994, Rothweiler & Clahsen 1993). These studies have considerably deepened our understanding of how linguistic knowledge is acquired and organised in the human mind. Their methodological procedures, however, do not involve measurements of how children process morphologically complex forms in real time. To date, little is known about how children process inflected word forms. The aim of this study is to investigate children’s processing of inflected words in a series of on-line reaction time experiments. We used a cross-modal priming experiment to test for decompositional effects on the central level. We used a speeded production task and a lexical decision task to test for frequency effects on access level in production and recognition. Children’s behaviour was compared to adults’ behaviour towards three participle types (-t participles, e.g. getanzt ‘danced’ vs. -n participles with stem change, e.g. gebrochen ‘broken’ vs.-n participles without stem change, e.g. geschlafen ‘slept’). For the central level, results indicate that -t participles but not -n participles have decomposed representations. For the access level, results indicate that -t participles are represented according to their morphemes and additionally as full forms, at least from the age of nine years onwards (Pinker 1999 and Clahsen et al. 2004). Further evidence suggested that -n participles are represented as full-form entries on access level and that -n participles without stem change may encode morphological structure (cf. Clahsen et al. 2003). Out data also suggests that processing strategies for -t participles are differently applied in recognition and production. These results provide evidence that children (within the age range tested) employ the same mechanisms for processing participles as adults. The child lexicon grows as children form additional full-form representations for -t participles on access level and elaborate their full-form lexical representations of -n participles on central level. These results are consistent with processing as explained in dual-system theories.
Landslides are one of the biggest natural hazards in Georgia, a mountainous country in the Caucasus. So far, no systematic monitoring and analysis of the dynamics of landslides in Georgia has been made. Especially as landslides are triggered by extrinsic processes, the analysis of landslides together with precipitation and earthquakes is challenging. In this thesis I describe the advantages and limits of remote sensing to detect and better understand the nature of landslide in Georgia. The thesis is written in a cumulative form, composing a general introduction, three manuscripts and a summary and outlook chapter. In the present work, I measure the surface displacement due to active landslides with different interferometric synthetic aperture radar (InSAR) methods. The slow landslides (several cm per year) are well detectable with two-pass interferometry. In same time, the extremely slow landslides (several mm per year) could be detected only with time series InSAR techniques. I exemplify the success of InSAR techniques by showing hitherto unknown landslides, located in the central part of Georgia. Both, the landslide extent and displacement rate is quantified. Further, to determine a possible depth and position of potential sliding planes, inverse models were developed. Inverse modeling searches for parameters of source which can create observed displacement distribution. I also empirically estimate the volume of the investigated landslide using displacement distributions as derived from InSAR combined with morphology from an aerial photography. I adapted a volume formula for our case, and also combined available seismicity and precipitation data to analyze potential triggering factors. A governing question was: What causes landslide acceleration as observed in the InSAR data? The investigated area (central Georgia) is seismically highly active. As an additional product of the InSAR data analysis, a deformation area associated with the 7th September Mw=6.0 earthquake was found. Evidences of surface ruptures directly associated with the earthquake could not be found in the field, however, during and after the earthquake new landslides were observed. The thesis highlights that deformation from InSAR may help to map area prone landslides triggering by earthquake, potentially providing a technique that is of relevance for country wide landslide monitoring, especially as new satellite sensors will emerge in the coming years.
Die Arbeit thematisiert die Veränderungen im deutschen Wissenschafts- und Hochschulsystem. Im Mittelpunkt steht die "unternehmerische Mission" von Universitäten. Der Blick wird auf das Aufgabenfeld Wissens- und Technologietransfer (WTT) gerichtet. Anhand dessen werden die Veränderungen, die innerhalb des deutschen Universitätssystems in den vergangenen Jahren erfolgten, nachgezeichnet. Die Erwartungshaltungen an Universitäten haben sich verändert. Ökonomische Sichtweisen nehmen einen immer größeren Stellenwert ein. Die Arbeit baut auf den Prämissen der neoinstitutionalistischen Organisationstheorie auf. Anhand dieser wird gezeigt, wie Erwartungen externer Stakeholder Eingang in Hochschulen finden und sich auf ihre organisatorische Ausgestaltung auswirken. Der Arbeit liegt ein exploratives, qualitatives Untersuchungsdesign zugrunde. In einer Fallstudie werden zwei Universitäten als Fallbeispiele untersucht. Die Untersuchung liefert Antworten auf die Fragen, wie der WTT als Aufgabenbereich an deutschen Universitäten umgesetzt wird, welche Strukturen sich herausgebildet haben und inwieweit eine Institutionalisierung des WTTs an Universitäten erfolgt ist. In der Arbeit werden verschiedene Erhebungsinstrumente im Rahmen einer Triangulation genutzt. Experteninterviews bilden das Hauptanalyseinstrument. Ziel der Untersuchung ist neben der Beantwortung der Forschungsfragen, Hypothesen zu bilden, die für weiterführende Untersuchungen genutzt werden können. Darüber hinaus werden Handlungsempfehlungen für die Umsetzung des WTTs an deutschen Hochschulen gegeben. Die Arbeit richtet sich sowohl an Wissenschaftler als auch Praktiker aus dem Bereich Wissens- und Technologietransfer.
One of the central questions in psycholinguistic is understanding whether and how prosodic phrase boundaries are used to resolve syntactic ambiguities in sentence processing. The present work aimed to answer both, first, the effects of φ- and ι-boundaries on syntactic ambiguity resolution, and second, how the prosodic correlates of the auditory input are taken for the phonetic-phonology mapping in order to attain a meaningful sentence interpretation.
With regard to the first aim, we investigated locally syntactic ambiguities involving either φ- or ι-phrase boundaries in German and the structural preference that listeners have, based on the prosodic content. The experiments described in this work show that German listeners exploit both types of prosodic phrase boundaries to resolve local syntactic ambiguities, that however, their disambiguation altered by the presence or absence of prosodic cues correlated with the corresponding boundary. Specifically, the perception data revealed that the phonetically measured prosodic correlates of each prosodic boundary such as pitch accents, boundary tones, deaccentuation and durational properties do not contribute to ambiguity resolution in equal measure. Rather, it is the case that listeners rely primarily on prefinal lengthening as a correlate of phrasing in the vicinity of φ-phrase boundaries, while at the level of the ι-phrase boundary, boundary tones serve as phrasal cues. This way the results of the present work take account of the as yet missing information on individual contributions of prosodic correlates on listeners’ disambiguation of syntactically ambiguous sentences in German. It further implies that the question of how German listeners resolve syntactic ambiguities cannot simply be attributed to the presence or absence of prosodic correlates. The interpretation of the phrasal structure rather depends on a more general picture of cohesion between prosodic correlates and prosodic boundary sizes.
With respect to the second aim, the processing models proposed in the present work describe a specific phonetics-phonology mapping in the vicinity of both phrase boundaries. It is assumed that auditory sentence processing proceeds in several successively organized steps, during which listeners transform overt phonetic forms into language specific abstract surface forms. This process is referred to as phonetics-phonology mapping in the present work. Perceptual evidence resulting from the experiments of the present work suggest that the phonetics-phonology mapping is guided by the above mentioned boundary related prosodic correlates. The resulting abstract phonological structure is subjected to the syntax-prosody mapping, in turn. The outcome of the presented perception experiments are modulated in an Optimality-Theoretic framework. The offered OT-models are grounded on the assumption that single prosodic correlates are used by listeners as a signal to syntax in sentence processing. This is in line with studies arguing that the prosodic phrase structure determines the syntactic parse (Cutler et al., 1997; Warren et al., 1995; Pynte & Prieur, 1996; Snedeker & Trueswell, 2003; Kjelgaard & Speer, 1999), to name just a few.
Folgt tatsächlich aus einem liberalen Wertekanon eine generative Selbstbestimmung, eine weitgehende elterliche Handlungsfreiheit bei eugenischen Maßnahmen, wie es Vertreter einer „liberalen Eugenik“ versichern? Diese Arbeit diskutiert die Rolle Staates und die Handlungsspielräume der Eltern bei der genetischen Gestaltung von Nachkommen im Rahmen eines liberalen Wertverständnisses.
Den Schwerpunkt/Fokus der Betrachtungen liegt hier Maßnahmen des genetic enhancement.
Darüber hinaus wird auch das Verhältnis der „liberalen Eugenik“ zur „autoritären Eugenik“ neu beleuchtet.
Die Untersuchung beginnt bei der Analyse zentraler liberaler Werte und Normen, wie Freiheit, Autonomie und Gerechtigkeit und deren Funktionen in der „liberalen Eugenik“. Wobei nur sehr eingeschränkt von der „liberalen Eugenik“ gesprochen werden kann, sondern viel mehr von Varianten einer „liberalen Eugenik“.
Darüber hinaus wird in dieser Arbeit die historische Entwicklung der „liberalen“ und der „autoritären Eugenik“, speziell des Sozialdarwinismus, untersucht und verglichen, insbesondere im Hinblick auf liberale Werte und Normen und der generativen Selbstbestimmung.
Den Kern der Arbeit bildet der Vergleich der „liberalen Eugenik“ mit der „liberalen Erziehung“. Da hier die grundlegenden Aufgaben der Eltern, aber auch des Staates, analysiert und deren Verhältnis diskutiert wird.
Es zeigt sich, dass sich aus einem liberalen Wertverständnisses heraus keine umfangreiche generative Selbstbestimmung ableiten lässt, sondern sich viel mehr staatlich kontrollierte enge Grenzen bei eugenischen Maßnahmen zum Wohle der zukünftigen Person, begründen.
Zudem wurde der Weg zur autoritären Eugenik nicht durch die Abkehr von der generativen Selbstbestimmung geebnet, sondern viel mehr durch die Übertragung des Fortschrittsgedankens auf den Menschen selbst. Damit verliert die generative Selbstbestimmung auch ihre Funktion als Brandmauer gegen eine autoritäre Eugenik. Nicht der Verlust der generativen Selbstbestimmung, sondern viel mehr die Idee der Perfektionierung des Menschen muss kritisch betrachtet und letztlich abgelehnt werden.
Ohne generative Selbstbestimmung und einer Perfektionierung des Menschen, bleibt nur eine Basis-Eugenik, bei der die Entwicklungsfähigkeit des Menschen sichergestellt wird, nicht jedoch seine Verbesserung.
Darüber hinaus muss auch über eine Entwicklungsmöglichkeit des zukünftigen Menschen gesprochen werden, d. h. ein minimales Potential zu gesellschaftlicher Integration muss gegeben sein. Nur wenn tatsächlich keine Möglichkeiten seitens der Gesellschaft bestehen eine Person zu integrieren und dieser eine Entwicklungsmöglichkeit zu bieten, wären eugenische Maßnahmen als letztes Mittel akzeptabel.
Die kumulative Dissertation zur Projektdidaktik trägt den Titel „Von der Konzeption zur Praxis: Zur Entwicklung der Projektdidaktik am Oberstufen-Kolleg Bielefeld und ihre Impulsgebung und Modellbildung für das deutsche Regelschulwesen“. Die Dissertation versteht sich als beispielgebende Umsetzung und Implementierung der Projektdidaktik für das Regelschulsystem. Auf der Basis von 22 bereits erschienenen Publikationen und einer Monographie werden mit fünf methodischen Zugriffen (bildungshistorisch, dichte Beschreibung, Aktionsforschung, empirische Untersuchung an Regelschulen und Implementierungsforschung, s. Kapitel 1) in sieben Kapiteln (2- 8) des systematischen ersten Teils die Entwicklung der Unterrichtsform Projektunterricht in der BRD, Projektbegriff und Weiterentwicklung des Konzepts, Methodik, Bewertung sowie Organisation des Projektunterrichts am Oberstufen-Kolleg, der Versuchsschule des Landes NRW, in Auseinandersetzung mit der allgemeinen Projektdidaktik dargestellt sowie Formen und Verfahren der erprobten Implementierung in das Regelschulsystem präsentiert.
Ein Schlusskapitel (9) fasst die Ergebnisse zusammen. Im umfangreichen Anhang finden sich verschiedene Publikationen zu Aspekten der Projektdidaktik, auf die der systematische Teil jeweils Bezug nimmt.
Die bildungshistorische Analyse (Kapitel 2) untersucht das Verhältnis von pädagogischer Theorie und schulischer Praxis, die weder in Literatur und noch in Praxis genügend verbunden sind. Nach der Rezeption der gut erforschten Konzeptgeschichte pädagogischer Theorie in Anlehnung an Dewey und Kilpatrick wird durch eine erste Analyse der „Praxisgeschichte“ des Projektunterrichts auf ein Forschungsdesiderat hingewiesen, dies auch um die Projektpraxis am Oberstufen-Kolleg in Beziehung zu der in den Regelschulen setzen zu können. Dabei wurden seit 1975 sechs Entwicklungslinien herausgearbeitet: Start, Krise und ihre Überwindung durch Öffnung und Vernetzung (1975-1990), didaktisch-methodische Differenzierung und Notwendigkeit von Professionalisierung (ab 1990) sowie Schulentwicklung und Institutionalisierung (seit Ende der 1990er Jahre).
Projektunterricht besteht am Oberstufen-Kolleg seit der Gründung 1974 als fest eingerichtete Unterrichtsform (seit 2002 zweimal jährlich 2 Wochen) mit dem Ziel, für das Regelschulsystem die Projektdidaktik zu erproben und weiterzuentwickeln. Als wichtige praxisorientierte Ziele wurden ein praxistauglicher Begriff, Bildungswert und Kompetenzen im Unterschied zum Lehrgang herausgearbeitet (z.B. handlungs- und anwendungsorientierte Kompetenzen) und das Verhältnis zum Fachunterricht bestimmt (Kapitel 3). Letzteres wurde am Beispiel des Fachs Geschichte entwickelt und exemplarisch in Formen der Verzahnung dargestellt (Kapitel 6).
Auch für die methodische Dimension galt, die allgemeine Projektdidaktik weiterzuentwickeln durch ihre Abgrenzung zu anderen Methoden der Öffnung von Schule und Unterricht (Kapitel 4). Dabei wurde als zentrales methodisches Prinzip die Handlungsorientierung bestimmt sowie sieben Phasen und jeweilige Handlungsschritte festgelegt. Besonders Planung und Rollenwechsel bedürfen dabei besonderer Beachtung, um Selbsttätigkeit der ProjektteilnehmerInnen zu erreichen. Verschiedene methodische „Etüden“ ( z.B. Gruppenarbeit, recherchieren, sich öffentlich verhalten), handlungsorientierte Vorformen und projektorientiertes Arbeiten sollten die Vollform Projektunterricht vorbereiten helfen.
Die Bewertung von Projekten (Kapitel 5) stellt andere Anforderungen als der Lehrgang, weil sie unterschiedliche Bewertungsebenen (z.B. Prozessbedeutung, Produktbeurteilung, Gruppenbewertung) umfasst. Dazu sind am Oberstufen-Kolleg andere Bewertungsformen als die Ziffernnote entwickelt worden: z.B. ein „Reflexionsbericht“ als individuelle Rückmeldung von SchülerInnen und LehrerInnen und ein „Zertifikat“ für besondere Leistungen im Projekt.
Zentral für die Entwicklung von Projektunterricht ist jedoch die Organisationsfrage (Kapitel 7). Dazu bedarf es einer Organisationsgruppe Projekt, die die Unterrichtsform didaktisch betreut und in einem Hearing die angemeldeten Projekte berät. Das Oberstufen-Kolleg hat damit eine entwickelte „Projektkultur“ organisatorisch umgesetzt. Für eine empirische Untersuchung an sechs Regelschulen in Ostwestfalen ist dann eine idealtypische Merkmalsliste von schulischer „Projektkultur“ als Untersuchungsinstrument entstanden, das zugleich als Leitlinie für Schulentwicklung im Bereich Projektlernen in den Regelschulen dienen kann. Zu dieser Implementierung (Kapitel 8) wurden Konzepte und Erfahrungen vom Oberstufen-Kolleg für schulinterne und schulexterne Fortbildungsformen sowie eine exemplarische Fortbildungseinheit entwickelt. So konnten in zahlreichen Lehrerfortbildungen durch die Versuchsschule Impulse für das Regelschulsystem gegeben werden.