Pride is linked to conviviality, to the practice of life-with-an-other, and to an awareness of the limitations of the life forms and life norms which guide and regulate the life of culturally, socially, and historically defined communities. Assuming this link, pride in living-together and conviviality appear as concepts creating a framework for future perspectives. But these concepts need a space in which they can unfold critically and confidently with a view to the future. For millennia, the literatures of the world have created this space of simulation and experimentation in which knowledge of how-to-live-with-an-other has been put down on paper through the open-ended tradition of writing. It is the space of the life forms and life norms of conviviality: it offers us prospective knowledge for the future by translating the imaginable into the thinkable, and the readable into the livable.

Most South Asian countries have challenges in ensuring water, energy, and food (WEF) security, which are often interacting positively or negatively. To address these challenges, the nexus approach provides a framework to identify the interactions of the WEF sectors as an integrated system. However, most nexus studies only qualitatively discuss the interactions between these sectors. This study conducts a systematic analysis of the WEF security nexus in South Asia by using open data sources at the country scale. We analyze interactions between the WEF sectors statistically, defining positive and negative correlations between the WEF security indicators as synergies and trade-offs, respectively. By creating networks of the synergies and trade-offs, we further identify most positively and negatively influencing indicators in the WEF security nexus. We observe a larger share of trade-offs than synergies within the water and energy sectors and a larger share of synergies than trade-offs among the WEF sectors for South Asia. However, these observations vary across the South Asian countries. Our analysis highlights that strategies on promoting sustainable energy and discouraging fossil fuel use could have overall positive effects on the WEF security nexus in the countries. This study provides evidence for considering the WEF security nexus as an integrated system rather than just a combination of three different sectors or securities.

India is facing a double burden of malnourishment with co-existences of under- and over-nourishment. Various socioeconomic factors play an essential role in determining dietary choices. Agriculture is one of the major emitters of greenhouse gases (GHGs) in India, contributing 18% of total emissions. It also consumes freshwater and uses land significantly. We identify eleven Indian diets by applying k-means cluster analysis on latest data from the Indian household consumer expenditure survey. The diets vary in calorie intake [2289-3218 kcal/Consumer Unit (CU)/day] and dietary composition. Estimated embodied GHG emissions in the diets range from 1.36 to 3.62 kg CO2eq./CU/day, land footprint from 4 to 5.45 m(2)/CU/day, whereas water footprint varies from 2.13 to 2.97m(3)/CU/day. Indian diets deviate from a healthy reference diet either with too much or too little consumption of certain food groups. Overall, cereals, sugar, and dairy products intake are higher. In contrast, the consumption of fruits and vegetables, pulses, and nuts is lower than recommended. Our study contributes to deriving required polices for the sustainable transformation of food systems in India to eliminate malnourishment and to reduce the environmental implications of the food systems. (c) 2020 Elsevier B.V. All rights reserved.

Porphyry copper deposits are formed by fluids released from felsic magmatic intrusions of batholithic dimensions, which are inferred to have been incrementally built up by a series of sill injections. The growth of the magma chamber is primarily controlled by the volumetric injection rate from deeper-seated magma reservoirs, but can further be influenced by hydrothermal convection and fluid release. To quantify the interplay between magma chamber growth, volatile expulsion and hydrothermal fluid flow during ore formation, we used numerical simulations that can model episodic sill injections in concert with multi-phase fluid flow. To build up a magma chamber that constantly maintains a small region of melt within a period of about 50 kyrs, an injection rate of at least 1.3 x 10(-3) km(3)/y is required. Higher magma influxes of 1.9 to 7.6 x 10(-3) km(3)/y are able to form magma chambers with a thickness of 2 to 3 km. Such an intrusion continuously produces magmatic volatiles which can precipitate a copper ore shell in the host rock about 2 km above the fluid injection location. The steady fluid flux from such an incrementally growing magma chamber maintains a stable magmatic fluid plume, precipitating a copper ore shell in a more confined region and resulting in higher ore grades than the ones generated by an instantaneous emplacement of a voluminous magma chamber. Our simulation results suggest that magma chambers related to porphyry copper deposits form by rapid and episodic injection of magma. Slower magma chamber growth rates more likely result in barren plutonic rocks, although they are geochemically similar to porphyry-hosting plutons. However, these low-frequency sill injection events without a significant magma chamber growth can generate magmatic fluid pulses that can reach the shallow subsurface and are typical for high-sulfidation epithermal deposits.

Antimicrobial resistance is an increasingly serious challenge for public health and could result in dramatic negative consequences for the health care sector during the next decades. To solve this problem, antibacterial materials that are unsusceptible toward the development of bacterial resistance are a promising branch of research. In this work, a new type of polymeric antimicrobial peptide mimic featuring a bottlebrush architecture is developed, using a combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and ring-opening metathesis polymerization (ROMP). This approach enables multivalent presentation of antimicrobial subunits resulting in improved bioactivity and an increased hemocompatibility, boosting the selectivity of these materials for bacterial cells. Direct probing of membrane integrity of treated bacteria revealed highly potent membrane disruption caused by bottlebrush copolymers. Multivalent bottlebrush copolymers clearly outperformed their linear equivalents regarding bioactivity and selectivity. The effect of segmentation of cationic and hydrophobic subunits within bottle brushes was probed using heterograft copolymers. These materials were found to self-assemble under physiological conditions, which reduced their antibacterial activity, highlighting the importance of precise structural control for such applications. To the best of our knowledge, this is the first example to demonstrate the positive impact of multivalence, generated by a bottlebrush topology in polymeric antimicrobial peptide mimics, making these polymers a highly promising material platform for the design of new bactericidal systems.

Recent theoretical investigations claim that tailored laser pulses may selectively steer benzene's aromatic ground state to localized non-aromatic excited states. For instance, it has been shown that electronic wavepackets, involving the two lowest electronic eigenstates, exhibit subfemtosecond charge oscillation between equivalent Kekule resonance structures. In this contribution, we show that such dynamical electron-localization in the molecule-fixed frame contravenes the principle of the indistinguishability of identical particles. This breach stems from a total omission of the nuclear degrees of freedom, giving rise to nonsymmetric electronic wavepackets under nuclear permutations. Enforcement of the latter leads to entanglement between the electronic and nuclear states. To obey quantum statistics, the entangled molecular states should involve compensating nuclear-permutation symmetries. This in turn engenders complete quenching of dynamical electron-localization in the molecule-fixed frame. Indeed, for the (six-fold) equilibrium geometry of benzene, group-theoretic analysis reveals that any electronic wavepacket exhibits a (D-6h) totally symmetric electronic density, at all times. Thus, our results clearly show that the six carbon atoms, and the six C-C bonds, always have equal Mulliken charges, and equal bond orders, respectively. However, electronic wavepackets may display dynamical localization of the electronic density in the space-fixed frame, whenever they involve both even and odd space-inversion (parity) or permutation-inversion symmetry. Dynamical spatial-localization can be probed experimentally in the laboratory frame, but it should not be deemed equivalent to charge oscillation between benzene's identical electronic substructures, such as Kekule resonance structures.

The GRACE-FO satellites launched in May 2018 are able to quantify the water mass deficit in Central Europe during the two consecutive summer droughts of 2018 and 2019. Relative to the long-term climatology, the water mass deficits were-112 +/- 10.5 Gt in 2018 and-145 +/- 12 Gt in 2019. These deficits are 73% and 94% of the mean amplitude of seasonal water storage variations, which is so severe that a recovery cannot be expected within 1 year. The water deficits in 2018 and 2019 are the largest in the whole GRACE and GRACE-FO time span. Globally, the data do not show an offset between the two missions, which proves the successful continuation of GRACE by GRACE-FO and thus the reliability of the observed extreme events in Central Europe. This allows for a joint assessment of the four Central European droughts in 2003, 2015, 2018, and 2019 in terms of total water storage deficits.

Context: Even after the Rosetta mission, some of the mechanical parameters of comet 67P/Churyumov-Gerasimenko's surface material are not yet well constrained. These parameters are needed to improve our understanding of cometary activity or for planning sample return missions. Aims: We study some of the physical processes involved in the formation of selected surface features and investigate the mechanical and geometrical parameters involved. Methods: Applying the discrete element method (DEM) in a low-gravity environment, we numerically simulated the surface layer particle dynamics involved in the formation of selected morphological features. The material considered is a mixture of polydisperse ice and dust spheres with inter-particle forces given by the Hertz contact model, translational friction, rolling friction, cohesion from unsintered contacts, and optionally due to bonds from ice sintering. We determined a working set of parameters that enables the simulations to be reasonably realistic and investigated morphological changes due to modifications thereof. Results: The selected morphological features are reasonably well reproduced using model materials with a tensile strength on the order of 1-10 Pa. Increasing the diameters of the spherical particles decreases the material strength, and increasing the friction leads to a more brittle but somewhat stronger material. High friction is required to make the material sufficiently brittle to match observations, which points to the presence of very rough, even angular particles. Reasonable seismic activity does not suffice to trigger the collapses of cliffs without material heterogeneities or structural defects. Conclusions: DEM modeling can be a powerful tool to investigate mechanical parameters of cometary surface material. However, many uncertainties arise from our limited understanding of particle shapes, spatial configurations, and size distributions, all on multiple length scales. Further numerical work, in situ measurements, and sample return missions are needed to better understand the mechanics of cometary material and cometary activity.

Background: Length-for-age is considered the indicator of choice in monitoring the long-term impact of chronic nutritional deficiency. Aim: We hypothesized that short term increments of body weight cross-correlate with increments of the lower leg length. Sample and methods: We re-analyzed the association between weekly measurements of weight and of lower leg length in 34 healthy German children, aged 2.9-15.9 years. The data are a subset of measurements originally published in 1988 (Hermanussen et al. 1988a). As the growth measurements were often not equally spaced in time due to interposed holidays and illness, the incremental rates for weight and lower leg length were smoothed using spline functions. Autocorrelation and cross-correlation functions were calculated for weight increments and lower leg length increments. Results: Height and weight increments are pulsatile. Autocorrelations indicated that mini growth spurts occur at irregular intervals. Lack of cross-correlations between weight and lower leg length indicated that mini spurts in weight gain do not coincide with mini spurts in length gain even when considering lag times of up to 10 weeks. Short term changes of weight gain and lower leg length gain in healthy children show no temporal association.

Die Sekundärprävention der koronaren Herzkrankheit umfasst einerseits eine pharmakologische, andererseits eine lebensstilbasierte Säule, die idealerweise interagieren und sich potenzieren. Neben der medikamentösen Blutdruck- und Lipideinstellung auf leitlinienorientierte Zielwerte ermöglichen moderne Antidiabetika eine Optimierung des glukometabolischen Kontinuums und eine Prognosebesserung. Die Lebensstiloptimierung setzt sich aus koronarprotektiver Ernährung, einer individualisierten Trainingstherapie, einer konsequenten Nikotinkarenz und stressreduzierenden Maßnahmen zusammen. Die kardiologische Rehabilitation (Phase II) schließt sich idealerweise unmittelbar einem stationären Aufenthalt wegen eines akuten Koronarereignisses an, kann aber auch im Rahmen einer stabilen Koronarsituation im Rahmen eines allgemeinen Antragsverfahrens durchgeführt werden. Randomisierte und prospektiv angelegte Interventionsstudien belegen die prognostische Wertigkeit der kardiologischen Rehabilitation auch im Zeitalter akuter Revaskularisationstherapie mit 24-h-PCI und moderner Pharmakotherapie.