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Endocardial cells are cardiac endothelial cells that line the interior of the heart tube. Historically, their contribution to cardiac development has mainly been considered from a morphological perspective. However, recent studies have begun to define novel instructive roles of the endocardium, as a sensor and signal transducer of biophysical forces induced by blood flow, and as an angiocrine signalling centre that is involved in myocardial cellular morphogenesis, regeneration and reprogramming. In this Review, we discuss how the endocardium develops, how endocardial-myocardial interactions influence the developing embryonic heart, and how the dysregulation of blood flowresponsive endocardial signalling can result in pathophysiological changes.
Measures for interoperability of phenotypic data: minimum information requirements and formatting
(2016)
Background: Plant phenotypic data shrouds a wealth of information which, when accurately analysed and linked to other data types, brings to light the knowledge about the mechanisms of life. As phenotyping is a field of research comprising manifold, diverse and time-consuming experiments, the findings can be fostered by reusing and combining existing datasets. Their correct interpretation, and thus replicability, comparability and interoperability, is possible provided that the collected observations are equipped with an adequate set of metadata. So far there have been no common standards governing phenotypic data description, which hampered data exchange and reuse. Results: In this paper we propose the guidelines for proper handling of the information about plant phenotyping experiments, in terms of both the recommended content of the description and its formatting. We provide a document called "Minimum Information About a Plant Phenotyping Experiment", which specifies what information about each experiment should be given, and a Phenotyping Configuration for the ISA-Tab format, which allows to practically organise this information within a dataset. We provide examples of ISA-Tab-formatted phenotypic data, and a general description of a few systems where the recommendations have been implemented. Conclusions: Acceptance of the rules described in this paper by the plant phenotyping community will help to achieve findable, accessible, interoperable and reusable data.
Background
The efficiency of multiplex editing in plants by the RNA-guided Cas9 system is limited by efficient introduction of its components into the genome and by their activity. The possibility of introducing large fragment deletions by RNA-guided Cas9 tool provides the potential to study the function of any DNA region of interest in its ‘endogenous’ environment.
Results
Here, an RNA-guided Cas9 system was optimized to enable efficient multiplex editing in Arabidopsis thaliana. We demonstrate the flexibility of our system for knockout of multiple genes, and to generate heritable large-fragment deletions in the genome. As a proof of concept, the function of part of the second intron of the flower development gene AGAMOUS in Arabidopsis was studied by generating a Cas9-free mutant plant line in which part of this intron was removed from the genome. Further analysis revealed that deletion of this intron fragment results 40 % decrease of AGAMOUS gene expression without changing the splicing of the gene which indicates that this regulatory region functions as an activator of AGAMOUS gene expression.
Conclusions
Our modified RNA-guided Cas9 system offers a versatile tool for the functional dissection of coding and non-coding DNA sequences in plants.
Results: Here, an RNA-guided Cas9 system was optimized to enable efficient multiplex editing in Arabidopsis thaliana. We demonstrate the flexibility of our system for knockout of multiple genes, and to generate heritable large-fragment deletions in the genome. As a proof of concept, the function of part of the second intron of the flower development gene AGAMOUS in Arabidopsis was studied by generating a Cas9-free mutant plant line in which part of this intron was removed from the genome. Further analysis revealed that deletion of this intron fragment results 40 % decrease of AGAMOUS gene expression without changing the splicing of the gene which indicates that this regulatory region functions as an activator of AGAMOUS gene expression. Conclusions: Our modified RNA-guided Cas9 system offers a versatile tool for the functional dissection of coding and non-coding DNA sequences in plants.
Flower development is a model system to understand organ specification in plants. The identities of different types of floral organs are specified by homeotic MADS transcription factors that interact in a combinatorial fashion. Systematic identification of DNA-binding sites and target genes of these key regulators show that they have shared and unique sets of target genes. DNA binding by MADS proteins is not based on ‘simple’ recognition of a specific DNA sequence, but depends on DNA structure and combinatorial interactions. Homeotic MADS proteins regulate gene expression via alternative mechanisms, one of which may be to modulate chromatin structure and accessibility in their target gene promoters.
Harmonized data file as the basis for comparative analysis of quality of life in the Candidate Countries and the European Union member states, based on seven different data sets, one Eurobarometer survey covering 13 Candidate Countries with an identical set of variables conducted in April 2002, the other six Standard Eurobarometer of different subjects and fielded in different years, each with another set of questions identical with the CC Eurobarometer. Selected aggregate indicators of quality of life ... describing the social situation in the EU15 and Candidate Countries.
How does the selection of a classical language at school affect prospects on the labor market? Even though research on the impact of horizontal educational inequalities on labor market outcomes has become prominent recently, this question has not yet attracted scholarly attention. Based on several differing approaches (Human Capital Theory, Signaling Theory, Homophily Principle), hypotheses are derived about the impact of the language profile at school on labor market prospects at career entry. To test these assumptions, a field experiment was conducted in which applications were submitted in response to job advertisements. Results show that choosing Latin and Ancient Greek has a positive impact on the chances of being invited to a job interview.
Datenanalyse mit Stata
(2016)
Dieses Buch bietet eine Einführung in das Datenanalysepaket Stata und ist zugleich das einzige Buch über Stata, das auch Anfängern eine ausreichende Erklärung statistischer Verfahren liefert. „Datenanalyse mit Stata' ist kein Befehls-Handbuch sondern erläutert alle Schritte einer Datenanalyse an praktischen Beispielen. Die Beispiele beziehen sich auf Themen der öffentlichen Diskussion oder der direkten Umgebung der meisten Leser. Damit eignet sich diese Buch als Einstieg in Data Analytics in allen Disziplinen.
Die neue Auflage bietet einen systematischeren Zugang zum Datenmanagement in Gegenwart von „Missing Values' und behandelt die in der Stata-Programmversion 14 implementierte Unicode-Codierung.
Was sollten Mitarbeiter in einem empirisch ausgerichteten Forschungsprojekt können, und welche Kernkompetenzen sollte die Ausbildung an den Universitäten daher vermitteln? Die Antworten auf diese Fragen hängen – wie sollte es anders sein – von der inhaltlichen Fragestellung und methodischen Ausrichtung des jeweiligen Forschungsprojektes ab. Natürlich sollten Projektmitarbeiter über Vorkenntnisse zum Forschungsthema verfügen. Natürlich sollten Kenntnisse des projektspezifischen (statistischen) Methodenarsenals vorliegen.