Refine
Has Fulltext
- no (304) (remove)
Year of publication
- 2019 (304) (remove)
Document Type
- Article (244)
- Doctoral Thesis (32)
- Other (17)
- Review (7)
- Conference Proceeding (2)
- Monograph/Edited Volume (1)
- Habilitation Thesis (1)
Keywords
- climate change (4)
- Arabidopsis (3)
- Arabidopsis thaliana (3)
- acid sphingomyelinase (3)
- animal personality (3)
- biodiversity (3)
- cytotoxicity (3)
- disturbance (3)
- global change (3)
- molybdenum cofactor (3)
- nutrition (3)
- population dynamics (3)
- temperature (3)
- ABC transporter (2)
- ABCB7 (2)
- Africa (2)
- Baltic Sea (2)
- Brachionus calyciflorus (2)
- Escherichia coli (2)
- Europe (2)
- Movement ecology (2)
- NAC (2)
- Phylogeny (2)
- ProDisc Vivo (2)
- Pseudomonas aeruginosa (2)
- Zebrafish (2)
- acid ceramidase (2)
- amitriptyline (2)
- ancient DNA (2)
- biogeography (2)
- body height (2)
- carbon (2)
- classical swine fever (2)
- conservation genetics (2)
- crop production (2)
- dispersal (2)
- distribution (2)
- eco-evolutionary experience (2)
- ecosystem services (2)
- edge effect (2)
- food webs (2)
- forest management (2)
- gene flow (2)
- landscape diversity (2)
- local adaptation (2)
- movement ecology (2)
- natural habitats (2)
- phenotypic plasticity (2)
- physical activity (2)
- plant diversity (2)
- seed bank (2)
- self-assembly (2)
- species assembly (2)
- stability (2)
- storage (2)
- time series analysis (2)
- vascular plants (2)
- wetland vegetation (2)
- wild boar (2)
- winter wheat (2)
- zinc (2)
- zooplankton (2)
- 16S rRNA gene sequencing (1)
- 2 Different Strains (1)
- 2-deoxy-D-ribose-5-phoshphate aldolase (1)
- ABC Transporter (1)
- AMSTAR (1)
- AMSTAR 2 (1)
- Abies alba (1)
- Abiotic stress (1)
- Acacia mellifera (1)
- Acer pseudoplatanus (1)
- Acinetobacter baumannii (1)
- Acoustic levitation (1)
- Actomyosin (1)
- Acute phase response (1)
- Adaptive dynamics (1)
- Adrenaline (1)
- Adrenochrome (1)
- Aeroponic cultivation (1)
- Aging (1)
- Agricultural landscape (1)
- Agricultural landscape generator (1)
- Alaska (1)
- Aldehyd (1)
- Aldehyd-oxidase (1)
- Aldehydoxidase (1)
- Algorithms (1)
- Alien species richness (1)
- Alternaria (1)
- Ambient pressure laser ionization (1)
- Amplicon sequencing (1)
- Amur River (1)
- Analysis (1)
- Anatomy (1)
- Ancient forest (1)
- Animal personality (1)
- Annual (1)
- Antarctica (1)
- Anthropocene (1)
- Aquatic fungi (1)
- Aquifers (1)
- Arbuscular mycorrhiza (1)
- Ascomyceten (1)
- Assay calibration (1)
- Assimilation efficiency (1)
- Atelerix albiventris (1)
- Atelerix algirus (1)
- Australia (1)
- Autoimmune diagnostics (1)
- Auxin (1)
- Auxin transport (1)
- BEMOVI (1)
- BIOMEX (1)
- BMI (1)
- BMP (1)
- Bacterial biosensor (1)
- Base cations (1)
- Bayesian inference (1)
- Beneficial mutations (1)
- Bewegungsökologie (1)
- Biochemistry (1)
- Biodiversity (1)
- Biodiversity Exploratories (1)
- Biogeography (1)
- Biologicals (1)
- Biomarker (1)
- Bird prey (1)
- Bird species richness (1)
- Blm10 (1)
- Bmp (1)
- Body perception (1)
- Body size (1)
- Body temperature (1)
- Body-Size (1)
- Bombina bombina (1)
- Brachionus (1)
- CAM (1)
- CD spectroscopy (1)
- CDOM (1)
- CO2 concentration (1)
- CO2 conditions (1)
- COR15A (1)
- CSD (1)
- Camelus bactrianus (1)
- Capsella (1)
- Carbon (1)
- Cardiac looping (1)
- Cardiovascular rehabilitation (1)
- Carex limosa (1)
- Cattle (1)
- Cell extrusion (1)
- Childhood traits and disorders (1)
- Chlorenchyma (1)
- Chlorophyll (1)
- Cholesterol (1)
- Chopralla (1)
- Chromatin (1)
- Citrobacter rodentium (1)
- Climate change (1)
- Clinical trial (1)
- ClinicalTrials (1)
- Cloeodes complex (1)
- Clostridioides difficile (1)
- Coating (1)
- Coherence number (1)
- Coherent partition (1)
- Coleoptera (1)
- Community (1)
- Community model (1)
- Community-weighted means (1)
- Competitive growth strategies (1)
- Computational biology and bioinformatics (1)
- Congo River (1)
- Conservation (1)
- Consortium (1)
- Coping styles (1)
- Coppice (1)
- Cross reactivity (1)
- Cultivated barley (1)
- DBD dye (1)
- DNA barcoding (1)
- DNA ejection (1)
- DNA origami (1)
- DNA viruses (1)
- DOC (1)
- DPE2 (1)
- Daphnia (1)
- Data quality (1)
- Database errors (1)
- Decomposition (1)
- Detection (1)
- Development (1)
- Diabetes (1)
- Dictyostelium (1)
- Direct electron transfer (1)
- Directional climate change (1)
- Disturbance (1)
- Dosing algorithm (1)
- Drought stress (1)
- Drugs (1)
- Dryopteridaceae (1)
- Dynamic sitting (1)
- EXPOSE-R2 (1)
- Echolocation (1)
- Ecological niche (1)
- Egg Size (1)
- Electropolymerization (1)
- Ellenberg indicator values (1)
- Encroachment (1)
- Enzymkinetik (1)
- Epigenetic memory (1)
- Epigenetics (1)
- Epitope imprinting (1)
- Eschericha coli (1)
- Eubacterium ramulus (1)
- Euro plus Med PlantBase (1)
- European hare (1)
- Evolution (1)
- Extremophiles (1)
- F-box (1)
- FNR (1)
- FT-ICR MS (1)
- FTIR-ATR (1)
- FTO (1)
- Faecal glucocorticoid metabolites (1)
- Fagus sylvatica (1)
- Farber disease (1)
- Feeding rate (1)
- Field conditions (1)
- Field pattern (1)
- Fire frequency (1)
- Fire-bellied toad (1)
- First-generation migrant (1)
- Fisch (1)
- Flexibility (1)
- Fluorescence microscopy (1)
- Food intake (1)
- Forest species (1)
- Formgedächtnispolymere (1)
- Fourier (1)
- Fragmentation (1)
- Fungal challenge (1)
- Fusarium (1)
- GBOL (1)
- GMP (1)
- GPS (1)
- GSNOR-GSNO reductase (1)
- Gas chromatography-mass spectrometry (GC-MS) (1)
- Gekkonidae (1)
- Gelbe Biotechnologie (1)
- Genetics (1)
- Genome assembly (1)
- Genomes (1)
- Glyphosate (1)
- Graph partitions (1)
- Gross growth efficiency (1)
- Groundwater (1)
- Growth adjustment (1)
- HIREC (1)
- Habitability (1)
- Habitat fragmentation (1)
- Habitat loss (1)
- Habitat selection (1)
- Heart development (1)
- Helarctos malayanus (1)
- Hemodynamics (1)
- Herbivorous insects (1)
- Heritability (1)
- High forest (1)
- Home range (1)
- HopZ1a (1)
- Humic acids (1)
- Hydrenchyma (1)
- Hydrology (1)
- IBD (1)
- Iberia (1)
- Impatiens (1)
- Individual-based models (1)
- Inert ingredients (1)
- Influenza A virus (1)
- Innate immunity (1)
- Insekten (1)
- Intensive care (1)
- Inter-individual differences (1)
- Interspecific interactions (1)
- Intraspecific competition (1)
- Intraspecific variation (1)
- Invertebrate pores (1)
- Ion optics (1)
- Ionmobility spectrometry (1)
- Isoenzyme (1)
- Isolation (1)
- Isthmus of Kra (1)
- Keratella cochlearis (1)
- Kettle holes (1)
- Krankheitsausbruch (1)
- Krankheitsökologie (1)
- Landscape of fear (1)
- Landscape simulator (1)
- Landschaftsheterogenität (1)
- Langmuir-Blodgett films (1)
- Late embryogenesis abundant (1)
- Leaf cavitation (1)
- Leaf metabolism (1)
- Learning (1)
- Leguminosae (1)
- Lepus europaeus (1)
- Life history traits (1)
- Life-History Consequences (1)
- Limitation (1)
- Limits of life (1)
- Locustella ochotensis (1)
- Lonchocarpus bussei (1)
- Lonchocarpus eriocalyx (1)
- Longitudinal (1)
- Low back pain (1)
- Lysiphlebus fabarum (1)
- MADS (1)
- MAMPs (1)
- Mars (1)
- Med-Checklist (1)
- Mediterranean (1)
- Metabolismus von Medikamenten (1)
- Metabolite QTL (1)
- Metabolite network (1)
- Metals (1)
- Methodological quality (1)
- Microbiology (1)
- Microsatellite (1)
- Middle East (1)
- Mitochondrien (1)
- Mixed mating (1)
- Molecular biology (1)
- Molybdän (1)
- Molybdänkofaktor (1)
- Monoclonal antibody (1)
- Monte Carlo method (1)
- Morphology (1)
- Morphometry (1)
- Mutation rate (1)
- Mutator locus (1)
- Myotis myotis (1)
- N (1)
- NET (1)
- NIA1 (1)
- NIA2 (1)
- NOR (1)
- NOS-like activity (1)
- NQR (1)
- Na+ - NADH:quinone oxidoreductase (1)
- Network clustering (1)
- Neutral landscape model (1)
- Nighttime illumination (1)
- Nitrospirae (1)
- Nrf2 (1)
- Nuclear magnetic resonance (1)
- Nutrient cycling (1)
- Nutritional quality (1)
- Nyctalus aviator (1)
- O-antigen specificity (1)
- Office chair (1)
- Oocytes (1)
- Oomycetous pathogen (1)
- Outcrossing (1)
- Outcrossing rate (1)
- Outdoor enclosure (1)
- Oxidative stress (1)
- Oxidoreduktase (1)
- P ratios (1)
- PAMPs (1)
- PBS1 (1)
- PLP-Walker A-overlap (1)
- PLP-Walker A-Überlagerung (1)
- Pachycladon (1)
- PanTHERIA (1)
- Paraechinus aethiopicus (1)
- Periplasma (1)
- Personality (1)
- Pex1 (1)
- Pex6 (1)
- Pharmacokinetics/pharmacodynamics (1)
- Pho1 (1)
- Pho2 (1)
- Phosphorus (1)
- Phytohormone (1)
- Picea abies (1)
- Pinus sylvestris (1)
- Plant functional traits (1)
- Plant signalling (1)
- Plant-soil feedback (1)
- Plastic surfaces (1)
- Polypodiales (1)
- Polyunsaturated Fatty-Acids (1)
- Population genetics (1)
- Population-Growth (1)
- Porosity (1)
- Post-agricultural forest (1)
- Predator-prey interactions (1)
- Pressure distribution (1)
- Principal Investigator (1)
- ProDisc C (1)
- Process-based model (1)
- Proepicardium (1)
- Protein-lipid interaction (1)
- Pseudomonas syringae (1)
- Pseudotsuga menziesii (1)
- Quaternions (1)
- R (Programmiersprache) (1)
- RNA in situ hybridization (1)
- RNA-directed DNA methylation (1)
- RNA-seq (1)
- ROBIS (1)
- ROP (1)
- ROS (1)
- Recombination (1)
- Redox marker (1)
- Renal function (1)
- Reproduction (1)
- Resource Competition (1)
- Respiration (1)
- Rhodobacter capsulatus (1)
- Risk avoidance behavior (1)
- Risk of bias (1)
- Rodent (1)
- Rodents (1)
- Root hair (1)
- Rotifier (1)
- Rstats (1)
- Russian empire (1)
- SAP (1)
- SCF complex (1)
- SOC (1)
- SPR (1)
- STERILE APETALA (1)
- Sahara-Sahel (1)
- Salmonella enterica (1)
- Salmonella myovirus (1)
- Sanger sequencing (1)
- Sargasso Sea (1)
- Savannas (1)
- Scincidae (1)
- Sea barley (1)
- Secretion (1)
- Sediment (1)
- Selective herbivory (1)
- Sf21 lysates (1)
- Shewanella (1)
- Sitting behaviour (1)
- SlTAF1 (1)
- Small mammal (1)
- Social group (1)
- Social network (1)
- Soil fertility (1)
- Soil function (1)
- Soil moisture (1)
- Specific dynamic action (1)
- Sphingosine (1)
- Staphylococcus aureus (1)
- Stress (1)
- Stress recovery (1)
- Sun bear (1)
- Superoxide (1)
- Sus scrofa (1)
- Systematic review (1)
- T cell receptor (1)
- T(h)1 (1)
- T(h)17 (1)
- TRPC6 (1)
- Terminalia catappa (1)
- Thickening (1)
- Tomato (1)
- Torpor (1)
- Trans-Golgi network (1)
- Trifluoroethanol (1)
- UV-B tolerance (1)
- Uredinopsis (1)
- Vegetation structure (1)
- Ventilation (1)
- Vibrio cholerae (1)
- VideoScan technology (1)
- Virus assembly (1)
- Volatile organic compound (VOC) (1)
- Volta River (1)
- WD40 (1)
- Walker A motif (1)
- Wastewater (1)
- Water flow (1)
- Weather (1)
- Wetland species (1)
- Wildschwein (1)
- Wnt (1)
- XFELs (1)
- YIP (1)
- Zellweger (1)
- Zellweger syndrome spectrum disorder (ZSSD) (1)
- Zinypr-1 (1)
- Zootoca vivipara (1)
- Zymosan (1)
- abiotic stress (1)
- abscisic acid (ABA) (1)
- acid ceramidase inhibitor ceranib-2 (1)
- activity (1)
- adaptation (1)
- adeno-associated-virus (1)
- admixture (1)
- adolescent growth (1)
- aerobic sports activity (1)
- agent-based model (1)
- agentenbasiertes Modell (1)
- aldehyde oxidase (1)
- allometry (1)
- alluvial soil (1)
- amino acids (1)
- anaerobic respiration (1)
- anchoring mechanism (1)
- and tissue-specificity (1)
- animal models (1)
- annexins (1)
- antheridiogens (1)
- anthropogenic interferences (1)
- anthropometry (1)
- antidepressants (1)
- antimikrobielle Peptide (1)
- antioxidant capacity (1)
- antisense transcription (1)
- apoplast (1)
- aquatic adaptation (1)
- aquatic-terrestrial interfaces (1)
- arenes (1)
- artificial protein binders (1)
- ascorbate peroxidase (1)
- asymmetry of competition (1)
- atomic force microscopy (1)
- attraction-avoidance (1)
- autogamy (1)
- auxin (1)
- bacterial pathogenesis (1)
- bacterial toxins (1)
- bacteriophage (1)
- baltic sea (1)
- bank voles (1)
- beeswax (1)
- beeswax substitutes (1)
- behavioral flexibility (1)
- behavioral plasticity (1)
- beta-Lactams (1)
- beta-lactamase (1)
- biodiversity exploratories (1)
- bioenergetic model (1)
- biofilm (1)
- biological invasions (1)
- biomarker (1)
- biomimetic sensors (1)
- bioremediation (1)
- blebbing (1)
- body proportions (1)
- bog/mire plants (1)
- brackish waters (1)
- bryophytes (1)
- buried horizon (1)
- bush encroachment (1)
- butyrylcholinesterase (1)
- calcite (1)
- calcium (1)
- calcium carbonate inclusions (1)
- canavanine (1)
- cancer immunotherapy (1)
- cancer markers (1)
- candelilla wax (1)
- canopy (1)
- capsid stability (1)
- carbon labeling (1)
- carbon nanotubes (CNTs) (1)
- carbon paper (1)
- carbon sinking flux (1)
- carbon uptake kinetics (1)
- carcasses (1)
- cardiovascular rehabilitation (1)
- carnauba wax (1)
- carrying capacity (1)
- catalase (1)
- cell (1)
- cell viability assay (1)
- cell-free protein synthesis (1)
- cellular antioxidant system (1)
- cellularization (1)
- centrality measures (1)
- centromere (1)
- centrosome (1)
- ceramide (1)
- cerebral cavernous malformations (1)
- cervical artificial disc replacement (1)
- cervical myelopathy (1)
- cervical total disc replacement (1)
- chemostat experiments (1)
- child growth (1)
- children (1)
- children and adolescents (1)
- chirality (1)
- cholesteryl ester (1)
- chromium (1)
- chytridiomycota (1)
- circadian rhythm (1)
- cleistogamy (1)
- cleptoparasitism (1)
- coastal dunes (1)
- coexistence (1)
- colitis (1)
- community composition (1)
- community ecology (1)
- community effect (1)
- community effect on height (1)
- community theory (1)
- compensatory dynamics (1)
- computationally simulated epitopes (1)
- confocal microscopy (1)
- conscripts (1)
- consumer diversity (1)
- contergan (1)
- contractile tail (1)
- coping styles (1)
- copper (1)
- core shell UCNP (1)
- correlation (1)
- costs (1)
- covariance (1)
- coviability analysis (1)
- cryptic diversity (1)
- cryptic species (1)
- cryptomycota (1)
- cyanobacteria (1)
- cytoglobin (1)
- dark diversity (1)
- decolorization (1)
- defense signaling pathways (1)
- demographic noise (1)
- desiccation (1)
- diacylglycerol (1)
- digestive acclimation (1)
- direct electron transfer (1)
- disc arthroplasty (1)
- disease ecology (1)
- disease invasion (1)
- disease persistence (1)
- dispersal mortality (1)
- disturbance intensity (1)
- disturbance type (1)
- diversity profiles (1)
- dndBCDE (1)
- drug metabolism (1)
- dry grasslands (1)
- dyes (1)
- dynamic energy budgets (1)
- early-warning signals (1)
- eco-evolutionary feedbacks (1)
- ecological interactions (1)
- ecological stoichiometry (1)
- ecological strategies (1)
- effectors (1)
- elicitors (1)
- empirical dynamic modelling (1)
- enantiospecificity (1)
- endosperm (1)
- endothelial cell (1)
- energy expenditure (1)
- environmental and general living conditions (1)
- environmental noise (1)
- enzymatic biofuel cell (1)
- enzymatically active membrane (1)
- enzyme immobilization (1)
- enzyme isoforms (1)
- enzyme kinetics (1)
- enzyme/polymer conjugate (1)
- epigenetics (1)
- epithionitrile (1)
- establishment (1)
- evolution (1)
- evolutionary rescue (1)
- exercise (1)
- experimental evolution (1)
- experimental plant communities (1)
- exploratory-behavior (1)
- expression (1)
- expression profile (1)
- extinction (1)
- extra-cytoplasmic pockets (1)
- fecundity (1)
- ferns (1)
- final height (1)
- fine-scale interactions (1)
- fire (1)
- fish (1)
- fitness gradient (1)
- flavanone (1)
- flavanonol (1)
- flavonoid (1)
- flow cytometry (1)
- flower development (1)
- fluorescence (1)
- fluorescent probe (1)
- fly pollination (1)
- food quality (1)
- forecasting (1)
- forest conversion (1)
- fossil pollen (1)
- fragmentation (1)
- free zinc (1)
- functional complementation (1)
- fungal community (1)
- fungal diversity (1)
- gamma diversity (1)
- gas chromatography-mass spectrometry (1)
- gene conversion (1)
- gene regulation (1)
- genetics (1)
- geographic neighborhood (1)
- geometric morphometrics (1)
- germ pores (1)
- glacial divergence (1)
- glacial refugia (1)
- global change ecology (1)
- glucose 1-phosphate transport (1)
- glucosinolate hydrolysis (1)
- glutathione (1)
- glutathione peroxidase (1)
- glycine cleavage system (1)
- glycobiology (1)
- gov (1)
- groundwater recharge (1)
- growth rate (1)
- guidelines (1)
- gynoecium development (1)
- habitat connectivity (1)
- habitat suitability (1)
- habitat use (1)
- health (1)
- heat shock proteins (1)
- height (1)
- helical structures (1)
- hemodynamics (1)
- hemoglobin (1)
- heterogeneity (1)
- heterotopic ossification (HO) (1)
- hilly loes plateau (1)
- holotype (1)
- homeostasis (1)
- homogenization (1)
- host alternation (1)
- host-parasite interaction (1)
- human aldehyde oxidase (1)
- hybridization (1)
- hybridization barrier (1)
- hybridization rate (1)
- hydrocortisone (1)
- hymenoptera (1)
- hyperforin (1)
- hyperglycemia (1)
- immunotherapy (1)
- impact on growth (1)
- implant design (1)
- importance (1)
- importin (1)
- individual differences (1)
- individual variability (1)
- individual-based model (1)
- individual-based modeling (1)
- inducible defence (1)
- infection risk (1)
- influenza (1)
- information theory (1)
- inner-mongolia (1)
- intake screening (1)
- integrative taxonomy (1)
- intensity vs (1)
- inter-individual differences (1)
- inter-specific interactions (1)
- interspecific hybridization (1)
- intestinal bacteria (1)
- intraspecific trait variation (1)
- intrinsically disordered proteins (1)
- introgression (1)
- invariability (1)
- invasion stages (1)
- invasive plant (1)
- inverted terminal repeat (ITR) (1)
- ion channel (1)
- ion homeostasis (1)
- iron (1)
- iron regulation (1)
- iron-sulfur cluster (1)
- islands (1)
- isoflavone (1)
- karyopherin (1)
- klassische Schweinepest (1)
- lamin (1)
- land sharing vs (1)
- land sharing vs. land sparing (1)
- land sparing (1)
- land-use (1)
- land-use change (1)
- land-use intensity niche (1)
- landscape connectivity (1)
- landscape heterogeneity (1)
- landscape scale (1)
- landscape structure (1)
- latitudinal gradient (1)
- leading/trailing edge (1)
- leaf (1)
- leaf hydraulic architecture (1)
- leaf midrib (1)
- least-cost path (1)
- lichens (1)
- life-history traits (1)
- life‐history traits (1)
- limb disproportions (1)
- lipid droplets (1)
- lipid membranes (1)
- lipid metabolism (1)
- lipid rafts (1)
- lipopolysaccharide (YLPS) (1)
- loop modification (1)
- low and middle-income (1)
- low temperature (1)
- lyso-phospholipids (1)
- lysosomal storage disorders (1)
- machine learning (1)
- magpie (1)
- male bank voles (1)
- management (1)
- mass production process (1)
- maternal aggression (1)
- maternal lineages (1)
- mathematical modeling (1)
- measles virus (1)
- membrane proteins (1)
- membrane repair (1)
- membranes (1)
- meta-analysis (1)
- metabolic engineering (1)
- metabolic theory (1)
- metacommunity dynamics (1)
- microbes (1)
- microclimate (1)
- microeukaryotes (1)
- microsomes (1)
- mitochondria (1)
- mitochondrial DNA (1)
- mitochondrial genome (1)
- mitogenome (1)
- modern coexistence theory (1)
- mojave desert (1)
- molecular evolution (1)
- molecular imprinting (1)
- molecular machine (1)
- molecularly imprinted polymers (1)
- mortality bias (1)
- movement behaviour (1)
- multi-adulteration (1)
- multidiversity (1)
- multidrug resistance (1)
- multivariate ratio analysis (1)
- museum collection (1)
- mustelid predation (1)
- mutation (1)
- myodes-glareolus (1)
- myoglobin (1)
- naringenin (1)
- natural killer cells (NK cells) (1)
- natural variation (1)
- nest-site selection (1)
- net primary productivity (1)
- network (1)
- network analysis (1)
- neuroglobin (1)
- neutral sphingomyelinase-2 (1)
- new combination (1)
- new record (1)
- new species (1)
- next-generation sequencing (1)
- niche partitioning (1)
- nitrate assimilation (1)
- nitrated proteins (1)
- nitric oxide-NO (1)
- nitrile (1)
- nitrogen (1)
- nitrogen availability (1)
- nitrogen deposition (1)
- nitrous-oxide (1)
- non-ripening (1)
- nonproteinogenic amino acid (1)
- novel ecosystems (1)
- nuclear envelop (1)
- nuclear transport (1)
- o-phenylenediamine (1)
- obesity (1)
- occurrence estimates (1)
- offspring-defense (1)
- one-carbon metabolism (1)
- optimal trait (1)
- ordinary differential equation (1)
- organ size (1)
- organic matter mineralization (1)
- outcrossing (1)
- oxygen affinity (1)
- pH (1)
- palaeogenome (1)
- paraffin (1)
- parameter estimation (1)
- parental age (1)
- pathogen persistence (1)
- percentage of fat mass (1)
- perennial (1)
- perfusion bioreactor (1)
- periodic flooding (1)
- permafrost (1)
- permutation entropy (1)
- persistence (1)
- persulfide (1)
- phage resistance (1)
- pharmacokinetics (1)
- phosphorus (1)
- phosphorus limitation (1)
- photorespiration (1)
- photosynthesis (1)
- phylogenetic regression (1)
- phylogeny (1)
- phytoplankton composition (1)
- phytoplankton photoacclimation (1)
- plant development (1)
- plant functional traits (1)
- plant interactions (1)
- plant invasion (1)
- plant performance (1)
- plant-plant interactions (1)
- plasma membrane (1)
- plastic-associated biofilms (1)
- plasticity (1)
- pollen development (1)
- poly(A) polymerase (1)
- polyethylene (1)
- polyploidy (1)
- polystyrene (1)
- polysulfide (1)
- population delimitation (1)
- population differentiation (1)
- population growth rate (1)
- population viability analysis (1)
- prairie vole (1)
- predation risk (1)
- predator prey (1)
- predator-prey dynamics (1)
- predator-prey interaction (1)
- pressures (1)
- priming (1)
- priming effects (1)
- professional and amateur athletes (1)
- proline (1)
- proteasomal degradation (1)
- proteasome (1)
- proteasome storage granules (1)
- protein microcrystals (1)
- protein recognition (1)
- protein-protein interactions (1)
- proteoliposomes (1)
- pseudogene (1)
- pterocarpan (1)
- pump (1)
- pyridoxal-50-phosphate (1)
- quantile regression (1)
- quasi-permanent plot (1)
- rain event depth (1)
- random forest (1)
- range expansions (1)
- rangeland (1)
- rapid evolution (1)
- re-survey (1)
- reaction norm (1)
- reactive nitrogen species (RNS) (1)
- reciprocal transplant experiment (1)
- recognition (1)
- recovery (1)
- reduced graphene oxide (1)
- reductase (1)
- regime shifts (1)
- remorin (1)
- reproductive isolation (1)
- reproductive strategies (1)
- resetting (1)
- resistance (1)
- resonance energy transfer (1)
- resource allocation (1)
- respiration (1)
- resurrection plants (1)
- rivastigmine (1)
- rodents (1)
- root and shoot competition (1)
- rooting depth (1)
- ruderal plant species (1)
- salinity gradient (1)
- salt stress (1)
- sample delivery (1)
- savanna ecology (1)
- schwach elektrische Fische (1)
- screen printed electrodes (SPEs) (1)
- seasonality (1)
- secular trend (1)
- sedimentary ancient DNA (1)
- seed development (1)
- seed morphology (1)
- sei whale (1)
- selenium (1)
- self-incompatibility (1)
- semi-arid savanna (1)
- senescence (1)
- serial femtosecond crystallography (1)
- serum (1)
- sex determination (1)
- sexual species (1)
- sexual/asexual reproduction (1)
- shape-memory polymers (1)
- shifting baselines (1)
- shrub encroachment (1)
- shrub size (1)
- siRNAs (1)
- simulation (1)
- single nucleotide polymorphism (1)
- skeleton (1)
- social environment (1)
- social information (1)
- socioeconomic status (1)
- soft actuators (1)
- soil bacterial diversity (1)
- space use (1)
- spatial-distribution (1)
- spatially induced variance (1)
- specialisation (1)
- specialized metabolites (1)
- speciation (1)
- species distribution model (1)
- species functional traits (1)
- species interactions (1)
- species niche (1)
- species richness (1)
- species-specific niche breadth (1)
- species-specific niche optima (1)
- specifier proteins (1)
- sphingolipids (1)
- sphingosine kinase (1)
- sphingosine kinase inhibitor SKI-II (1)
- stable isotopes (1)
- stable states (1)
- starch metabolism (1)
- state and transition (1)
- statistical tools (1)
- stearic acid (1)
- step-selection function (1)
- sterols (1)
- strength training (1)
- stress (1)
- stress tolerance (1)
- structural biology (1)
- structural equation modeling (1)
- structure (1)
- subtropical convergence zone (1)
- succulent karoo (1)
- sugar transport (1)
- sulfite oxidase (1)
- sulfur-bacteria (1)
- sulphur metabolism (1)
- superoxide dismutase (1)
- survival (1)
- switching function (1)
- sycamore maple (1)
- synthetic biology (1)
- tailspike protein (1)
- tallow (1)
- taxonomy (1)
- temperate (1)
- temperate forests (1)
- temperate grasslands (1)
- temperature increase (1)
- temperature variability (1)
- tetrahydrofolate (1)
- thalassoidism (1)
- thalidomide embryopathy (1)
- the Caucasus (1)
- thermal performance (1)
- thermoplastic polymers (1)
- thermoplastischen Polymere (1)
- threshold (1)
- time-resolved luminescence (1)
- tissue specificity (1)
- tomato (1)
- top-down control (1)
- total conductive area (1)
- total disc replacement (1)
- trade-offs (1)
- trait adaptation (1)
- trait variability (1)
- transcortin (1)
- transcription factor (1)
- transcription factors (1)
- transcriptional interference (1)
- transcriptome (1)
- transporter (1)
- transposable elements (1)
- tree species diversity (1)
- tree-grass interactions (1)
- triploid block (1)
- trnL-trnF (1)
- tropical (1)
- tropical freshwater fish (1)
- tropische Süßwasser Fische (1)
- tumor immunity (1)
- tumor microenvironment (1)
- tumor-associated macrophage (1)
- type-3 secretion (1)
- ubiquitin (1)
- unbalanced diets (1)
- vegan (1)
- vegetarian (1)
- vegetation dynamics (1)
- vessel diameter (1)
- vessel number (1)
- viral matrix proteins (1)
- vole clethrionomys-glareolus (1)
- voles clethrionomys-glareolus (1)
- weakly electric fish (1)
- weiche Aktuatoren (1)
- wet grasslands (1)
- wildlife corridors (1)
- wildlife disease (1)
- xanthine oxidase (1)
- yedoma (1)
- zebrafish (1)
- zebularine (1)
Institute
- Institut für Biochemie und Biologie (304) (remove)
Aldol reactions play an important role in organic synthesis, as they belong to the class of highly beneficial C-C-linking reactions. Aldol-type reactions can be efficiently and stereoselectively catalyzed by the enzyme 2-deoxy-D-ribose-5-phosphate aldolase (DERA) to gain key intermediates for pharmaceuticals such as atorvastatin. The immobilization of DERA would open the opportunity for a continuous operation mode which gives access to an efficient, large-scale production of respective organic intermediates. In this contribution, we synthesize and utilize DERA/polymer conjugates for the generation and fixation of a DERA bearing thin film on a polymeric membrane support. The conjugation strongly increases the tolerance of the enzyme toward the industrial relevant substrate acetaldehyde while UV-cross-linkable groups along the conjugated polymer chains provide the opportunity for covalent binding to the support. First, we provide a thorough characterization of the conjugates followed by immobilization tests on representative, nonporous cycloolefinic copolymer supports. Finally, immobilization on the target supports constituted of polyacrylonitrile (PAN) membranes is performed, and the resulting enzymatically active membranes are implemented in a simple membrane module setup for the first assessment of biocatalytic performance in the continuous operation mode using the combination hexanal/acetaldehyde as the substrate.
Apoptotic death of cells damaged by genotoxic stress requires regulatory input from surrounding tissues. The C. elegans scaffold protein KRI-1, ortholog of mammalian KRIT1/CCM1, permits DNA damage-induced apoptosis of cells in the germline by an unknown cell non-autonomous mechanism. We reveal that KRI-1 exists in a complex with CCM-2 in the intestine to negatively regulate the ERK-5/MAPK pathway. This allows the KLF-3 transcription factor to facilitate expression of the SLC39 zinc transporter gene zipt-2.3, which functions to sequester zinc in the intestine. Ablation of KRI-1 results in reduced zinc sequestration in the intestine, inhibition of IR-induced MPK-1/ERK1 activation, and apoptosis in the germline. Zinc localization is also perturbed in the vasculature of krit1(-/-) zebrafish, and SLC39 zinc transporters are mis-expressed in Cerebral Cavernous Malformations (CCM) patient tissues. This study provides new insights into the regulation of apoptosis by cross-tissue communication, and suggests a link between zinc localization and CCM disease.
Diagnostics of Autoimmune Diseases involve screening of patient samples for containing autoantibodies against various antigens. To ensure quality of diagnostic assays a calibrator is needed in each assay system. Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of polyclonal sera from other species. Nevertheless, the detection of human autoantibodies as well as the calibration reagent containing antibodies from other species in one assay constitutes a challenge in terms of assay calibration. We therefore developed a cross-reactive monoclonal antibody which binds human as well as rabbit sera with similar affinities in the nanomolar range. We tested our monoclonal antibody S38CD11B12 successfully in the commercial Serazym (R) Anti-Cardiolipin-beta 2-GPI IgG/IgM assay and could thereby prove the eligibility of S38CD11B12 as detection antibody in autoimmune diagnostic assays using rabbit derived sera as reference material.
A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A
(2019)
The genetics of many congenital heart diseases (CHDs) can only unsatisfactorily be explained by known chromosomal or Mendelian syndromes. Here, we present sequencing data of a family with a potentially multigenic origin of CHD. Twelve of nineteen family members carry a familial mutation [NM_004329.2:c.1328 G > A (p.R443H)] which encodes a predicted deleterious variant of BMPR1A. This mutation co-segregates with a linkage region on chromosome 1 that associates with the emergence of severe CHDs including Ebstein’s anomaly, atrioventricular septal defect, and others. We show that the continuous overexpression of the zebrafish homologous mutation bmpr1aap.R438H within endocardium causes a reduced AV valve area, a downregulation of Wnt/ß-catenin signalling at the AV canal, and growth of additional tissue mass in adult zebrafish hearts. This finding opens the possibility of testing genetic interactions between BMPR1A and other candidate genes within linkage region 1 which may provide a first step towards unravelling more complex genetic patterns in cardiovascular disease aetiology.
Background: The outcrossing rate is a key determinant of the population-genetic structure of species and their long-term evolutionary trajectories. However, determining the outcrossing rate using current methods based on PCRgenotyping individual offspring of focal plants for multiple polymorphic markers is laborious and time-consuming.
Results: We have developed an amplicon-based, high-throughput enabled method for estimating the outcrossing rate and have applied this to an example of scented versus non-scented Capsella (Shepherd’s Purse) genotypes. Our results show that the method is able to robustly capture differences in outcrossing rates. They also highlight potential biases in the estimates resulting from differential haplotype sharing of the focal plants with the pollen-donor population at individual amplicons.
Conclusions: This novel method for estimating outcrossing rates will allow determining this key population-genetic parameter with high-throughput across many genotypes in a population, enabling studies into the genetic determinants of successful pollinator attraction and outcrossing.
A Metabarcoding Analysis of the Mycobiome of Wheat Ears Across a Topographically Heterogeneous Field
(2019)
By using an integrative approach, we describe a new species of mayfly, Bungona (Chopralla) pontica sp. n., from Turkey. The discovery of a representative of the tropical mayfly genus Bungona in the Middle East is rather unexpected. The new species shows all the main morphological characters of the subgenus Chopralla, which has its closest related species occurring in southeastern Asia. Barcoding clearly indicated that the new species represents an independent lineage isolated for a very long time from other members of the complex. The claw is equipped with two rows of three or four flattened denticles. This condition is a unique feature of Bungona (Chopralla) pontica sp. n. among West Palaearctic mayfly species. Within the subgenus Chopralla, the species can be identified by the presence of a simple, not bifid right prostheca (also present only in Bungona (Chopralla) liebenauae (Soldan, Braasch & Muu, 1987)), the shape of the labial palp, and the absence of protuberances on pronotum.
Most biochemical reactions depend on the pH value of the aqueous environment and some are strongly favoured to occur in an acidic environment. A non-invasive control of pH to tightly regulate such reactions with defined start and end points is a highly desirable feature in certain applications, but has proven difficult to achieve so far. We report a novel optical approach to reversibly control a typical biochemical reaction by changing the pH and using acid phosphatase as a model enzyme. The reversible photoacid G-acid functions as a proton donor, changing the pH rapidly and reversibly by using high power UV LEDs as an illumination source in our experimental setup. The reaction can be tightly controlled by simply switching the light on and off and should be applicable to a wide range of other enzymatic reactions, thus enabling miniaturization and parallelization through non-invasive optical means.
Objectives: The objectives of this study were to determine the interrater reliability (IRR) of assessment of multiple systematic reviews (AMSTAR) 2 for reviews of pharmacological or psychological interventions for the treatment of major depression, to compare it to that of AMSTAR and risk of bias in systematic reviews (ROBIS), and to assess the convergent validity between the appraisal tools. Results: The median kappa values as a measure of IRR indicated a moderate agreement for AMSTAR 2 (median = 0.51), a substantial agreement for AMSTAR (median = 0.62), and a fair agreement for ROBIS (median = 0.27). Validity results showed a positive association for AMSTAR and AMSTAR 2 (r = 0.91) as well as ROBIS and AMSTAR 2 (r = 0.84). For the overall rating, AMSTAR 2 showed a high concordance with ROBIS and a lower concordance with AMSTAR. Conclusion: The IRR of AMSTAR 2 was found to be slightly lower than the IRR of AMSTAR and higher than the IRR of ROBIS. Validity measurements indicate that AMSTAR 2 is closely related to both ROBIS and AMSTAR. (C) 2019 Elsevier Inc. All rights reserved.
As sessile life forms, plants are repeatedly confronted with adverse environmental conditions, which can impair development, growth, and reproduction. During evolution, plants have established mechanisms to orchestrate the delicate balance between growth and stress tolerance, to reset cellular biochemistry once stress vanishes, or to keep a molecular memory, which enables survival of a harsher stress that may arise later. Although there are several examples of memory in diverse plants species, the molecular machinery underlying the formation, duration, and resetting of stress memories is largely unknown so far. We report here that autophagy, a central self-degradative process, assists in resetting cellular memory of heat stress (HS) in Arabidopsis thaliana. Autophagy is induced by thermopriming (moderate HS) and, intriguingly, remains high long after stress termination. We demonstrate that autophagy mediates the specific degradation of heat shock proteins at later stages of the thermorecovery phase leading to the accumulation of protein aggregates after the second HS and a compromised heat tolerance. Autophagy mutants retain heat shock proteins longer than wild type and concomitantly display improved thermomemory. Our findings reveal a novel regulatory mechanism for HS memory in plants.