Refine
Has Fulltext
- no (53)
Document Type
- Article (53) (remove)
Is part of the Bibliography
- yes (53)
Keywords
- allostatic load (2)
- cortisol (2)
- depression (2)
- low back pain (2)
- neuroplasticity (2)
- reliability (2)
- sonography (2)
- tVNS (2)
- 3-BrPA (1)
- Advanced Dynamic Flow (1)
- Aging (1)
- Alpha-2 (1)
- Aluminum (1)
- Ankle injury (1)
- Ankle sprain (1)
- B8 fibroblasts (1)
- BDNF (1)
- Basketball (1)
- Breath analysis (1)
- C12orf35 (1)
- COVID-19 (1)
- CRISPR (1)
- Cardiac rehabilitation (1)
- Case (1)
- Children (1)
- Coercion (1)
- Crisis management (1)
- Danger to others (1)
- Depression (1)
- Developmental delay (1)
- Digital Health (1)
- Doppler ultrasound (1)
- Drosophila wing imaginal disc (1)
- E. coli tyrosyl-tRNA synthetase (1)
- EEG (1)
- ERPs (1)
- Einstellungen zur Pflegerobotik (1)
- Electronic Health (1)
- Ethics (1)
- Ethics committee (1)
- Ethikkomitee (1)
- Ethische Fallbesprechung (1)
- Extracelluar wingless (1)
- Fallbesprechung (1)
- Force plate (1)
- Functional ankle instability (1)
- HIV (1)
- Health inequalities (1)
- ICA (1)
- Imaginal disc dissection (1)
- Implementation (1)
- Implementierung (1)
- Inpatient psychiatric care (1)
- LPP (1)
- M. mazei pyrrolysyl-tRNA synthetase (1)
- MCAO (1)
- MCI (1)
- MPNST (1)
- MRI (1)
- Media (1)
- Medical humanities (1)
- MiSpEx (1)
- Mobile Health (1)
- Moral case (1)
- Morphogen signaling (1)
- NF1 (1)
- Neurotoxicity (1)
- New effect (1)
- Nijmegen interactive model (1)
- Nimwegener Modell (1)
- Nordic walking (1)
- Old (1)
- Older patients (1)
- Organisationsethik (1)
- Organizational ethics (1)
- PA28 (1)
- PCR– RFLP (1)
- PNPLA3 (1)
- Per oral administration (1)
- Perceived ankle instability (1)
- Personnel resources (1)
- Physical activity (1)
- Physical training (1)
- Postural control (1)
- Practice report (1)
- Praxisbericht (1)
- Pseudomonas aeruginosa (1)
- Psychometric evaluation (1)
- Rats (1)
- Recycling assay (1)
- Regional deprivation (1)
- Risiken und Vorteile (1)
- Risk competence (1)
- Risk perception (1)
- Rurality (1)
- SARS-CoV‑ 2 (1)
- Science, technology and society (1)
- Social functioning (1)
- Spatial analysis (1)
- Sub-chronic exposure (1)
- Survey (1)
- TAVI (1)
- TMS (1)
- Telehealth (1)
- Telemedicine (1)
- Test-retest (1)
- Theta (1)
- Trace elements (1)
- Translation (1)
- VBM (1)
- Ward size (1)
- Wingless/Wnt secretion (1)
- Workability (1)
- activated caspase 3 (1)
- advanced dynamic flow (1)
- aerobic power (1)
- affective (1)
- aging (1)
- allostatic load index (1)
- alpha-amylase (1)
- amber suppression (1)
- anterior discectomy and fusion (1)
- anxiety (1)
- assay (1)
- athlete (1)
- attention (1)
- autoantibody (1)
- balance (1)
- basic need satisfaction and frustration (1)
- basic psychological need frustration (1)
- biochemistry (1)
- biomarker discovery (1)
- bone remodeling (1)
- boredom (1)
- brain health (1)
- cTBS (1)
- cardiology (1)
- cell cycle (1)
- cell-free protein synthesis (1)
- cervical spine surgery (1)
- chronic back pain (1)
- clinical research (1)
- clinical sample (1)
- coatings (1)
- cognition (1)
- cystic fibrosis (1)
- dehydroepiandrosterone sulfate (1)
- deliberation (1)
- deliberations (1)
- demografische Faktoren (1)
- dentate gyrus (1)
- depressive symptoms (1)
- disease (1)
- elderly (1)
- electrical muscle stimulation (1)
- emotion (1)
- enzyme-linked immunosorbent (1)
- epidemiology (1)
- epinephrine (1)
- exercise (1)
- exercise cognition (1)
- exercise intensity (1)
- football (1)
- frailty tool (1)
- glycolysis (1)
- hair cortisol (1)
- handgrip strength (1)
- heart rate (1)
- hippocampal-prefrontal network (1)
- hypocortisolemic symptom triad (1)
- hypoechogenicities (1)
- immunology (1)
- inflammation (1)
- insulin (1)
- interleukin-8 (1)
- internal load (1)
- intratendinous blood flow (1)
- laboratory medicine (1)
- linear sprint (1)
- locus coeruleus (1)
- long-term effects (1)
- macrophages (1)
- membrane protein (1)
- memory (1)
- mental health (1)
- metabolic syndrome (1)
- microRNA (1)
- mild cognitive impairment (1)
- mitochondrial respiration (1)
- mortality (1)
- multidisciplinary intervention (1)
- multimodal intervention (1)
- musculoskeletal (1)
- myasthenia gravis (1)
- n-3 polyunsaturated fatty acid therapies (1)
- need profiles (1)
- need satisfaction (1)
- neovascularization (1)
- neurobiological (1)
- neurogenesis (1)
- neuromodulation (1)
- neuropsychological testing (1)
- nonalcoholic fatty liver (1)
- noradrenaline (1)
- norepinephrine (1)
- older patients (1)
- orthogonal translation (1)
- osteoblast (1)
- osteoclast (1)
- p53 (1)
- pathogens (1)
- postural control (1)
- precuneus (1)
- primary marker (1)
- prostaglandin E-2 (1)
- proteins (1)
- psychosocial moderators (1)
- pupillometry (1)
- pyknotic cells (1)
- quarantine (1)
- recurrent laryngeal nerve palsy (1)
- reproducibility (1)
- repräsentative Studien (1)
- resting-state fMRI (1)
- reversal learning (1)
- rs738409 (1)
- salivary (1)
- sensorimotor training intervention (1)
- social constructivism (1)
- social environment (1)
- solid-phase (1)
- spatial updating (1)
- starvation (1)
- stress types (1)
- surface chemistry (1)
- sustainability (1)
- tendinopathy (1)
- transcutaneous auricular vagus nerve stimulation (1)
- treadmill (1)
- ultrasound (1)
- vagus nerve (1)
- vagus nerve stimulation (1)
- vascularization (1)
- vocal cord palsy (1)
- volatile organic compounds (1)
- walking (1)
- well-being (1)
- young athletes (1)
- youth (1)
- „Ambient assisted living“ (1)
Institute
- Fakultät für Gesundheitswissenschaften (53) (remove)
Myasthenia gravis is an autoimmune disease affecting neuromuscular transmission and causing skeletal muscle weakness. Additionally, systemic inflammation, cognitive deficits and autonomic dysfunction have been described.
However, little is known about myasthenia gravis-related reorganization of the brain. In this study, we thus investigated the structural and functional brain changes in myasthenia gravis patients.
Eleven myasthenia gravis patients (age: 70.64 +/- 9.27; 11 males) were compared to age-, sex- and education-matched healthy controls (age: 70.18 +/- 8.98; 11 males). Most of the patients (n = 10, 0.91%) received cholinesterase inhibitors.
Structural brain changes were determined by applying voxel-based morphometry using high-resolution T-1-weighted sequences. Functional brain changes were assessed with a neuropsychological test battery (including attention, memory and executive functions), a spatial orientation task and brain-derived neurotrophic factor blood levels.
Myasthenia gravis patients showed significant grey matter volume reductions in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus. Furthermore, myasthenia gravis patients showed significantly lower performance in executive functions, working memory (Spatial Span, P = 0.034, d = 1.466), verbal episodic memory (P = 0.003, d = 1.468) and somatosensory-related spatial orientation (Triangle Completion Test, P = 0.003, d = 1.200).
Additionally, serum brain-derived neurotrophic factor levels were significantly higher in myasthenia gravis patients (P = 0.001, d = 2.040). Our results indicate that myasthenia gravis is associated with structural and functional brain alterations. Especially the grey matter volume changes in the cingulate gyrus and the inferior parietal lobe could be associated with cognitive deficits in memory and executive functions.
Furthermore, deficits in somatosensory-related spatial orientation could be associated with the lower volumes in the inferior parietal lobe. Future research is needed to replicate these findings independently in a larger sample and to investigate the underlying mechanisms in more detail.
Klaus et al. compared myasthenia gravis patients to matched healthy control subjects and identified functional alterations in memory functions as well as structural alterations in the cingulate gyrus, in the inferior parietal lobe and in the fusiform gyrus.