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We study the minimal and maximal closed extension of a differential operator A on a manifold B with conical singularities, when A acts as an unbounded operator on weighted Lp-spaces over B,1 < p < ∞. Under suitable ellipticity assumptions we can define a family of complex powers A up(z), z ∈ C. We also obtain sufficient information on the resolvent of A to show the boundedness of the pure imaginary powers. Examples concern unique solvability and maximal regularity of the solution of the Cauchy problem u' - Δu = f, u(0) = 0, for the Laplacian on conical manifolds.