Refine
Has Fulltext
- no (51)
Year of publication
Document Type
- Article (51) (remove)
Language
- English (51)
Is part of the Bibliography
- yes (51)
Keywords
- Dictyostelium discoideum (3)
- chemotaxis (3)
- Dictyostelium (2)
- diffusion (2)
- pattern formation (2)
- systems (2)
- Actin cytoskeleton dynamics (1)
- Actin dynamics (1)
- Actin waves (1)
- Cell fusion (1)
Institute
A theory for diffusivity estimation for spatially extended activator-inhibitor dynamics modeling the evolution of intracellular signaling networks is developed in the mathematical framework of stochastic reaction-diffusion systems. In order to account for model uncertainties, we extend the results for parameter estimation for semilinear stochastic partial differential equations, as developed in Pasemann and Stannat (Electron J Stat 14(1):547-579, 2020), to the problem of joint estimation of diffusivity and parametrized reaction terms. Our theoretical findings are applied to the estimation of effective diffusivity of signaling components contributing to intracellular dynamics of the actin cytoskeleton in the model organism Dictyostelium discoideum.